Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Structural Studies of Wnt Signaling
Discussion Leader: Roeland Nusse (Stanford University, USA)
7:40 pm - 8:05 pm
William Weis (Stanford University School of Medicine, USA)
"Molecular Mechanisms in Wnt/Beta-Catenin Signal Transduction"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Yvonne Jones (Wellcome Centre for Human Genetics, University of Oxford, United Kingdom)
"Structure and Mechanism in the Assembly and Modulation of Wnt Signalling Complexes"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:10 pm
Wenqing Xu (University of Washington, USA)
"Structure of Wnt Enhanceosome"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Michael Ranes (Institute of Cancer Research, United Kingdom)
"Biochemical Reconstitution of Wild-Type and Oncogenic Core β-Catenin Destruction Complexes"
9:25 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Wnt Signal Transduction
Discussion Leader: Ken Cadigan (University of Michigan, USA)
9:00 am - 9:25 am
Xi He (Boston Children's Hospital / Harvard Medical School, USA)
"Wnt Regulation of Development and Stem Cell Biology"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Feng Cong (Novartis Institutes for BioMedical Research, USA)
"Control of Wnt/Beta-Catenin Signaling by the Ubiquitin System"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Andres Lebensohn (National Cancer Institute, NIH, USA)
"The Ubiquitin Ligase HUWE1 Regulates Canonical WNT Signaling Independently of Changes in Beta-Catenin Abundance"
10:20 am - 10:25 am
Discussion
10:25 am - 10:50 am
Coffee Break
10:50 am - 11:15 am
Madelon Maurice (University Medical Center Utrecht, The Netherlands)
"Mutation-Guided Insights in Wnt Signalling Regulation"
11:15 am - 11:25 am
Discussion
11:25 am - 11:50 am
Mark Peifer (University of North Carolina at Chapel Hill, USA)
"Supramolecular Assembly of the Beta-Catenin Destruction Complex and the Effect of Wnt Signaling on Its Localization, Molecular Size and Activity In Vivo "
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Vitezslav Bryja (Masaryk University, Czech Republic)
"Structural Consequences of Dishevelled Phosphorylation by CK1 Epsilon"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Wenzhe Ma (Harvard Medical School, USA)
"Single Molecule Dynamics of Dishevelled at the Plasma Membrane and Wnt Pathway Activation"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizer: Renee Van Amerongen (University of Amsterdam, The Netherlands)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Control of Gene Expression
Discussion Leader: Renee Van Amerongen (University of Amsterdam, The Netherlands)
7:30 pm - 7:55 pm
Alexander Aulehla (European Molecular Biology Laboratory Heidelberg, Germany)
"Oscillatory Wnt-Signaling Dynamics During Mouse Embryo Development"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Ken Cadigan (University of Michigan, USA)
"Sox9 and Wnt Signaling: Two Sides to the Coin"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Akira Kikuchi (Graduate School of Medicine, Osaka University, Japan)
"The Novel Target Molecule of Wnt/Beta-Catenin Signaling and Cancer"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Babita Madan (Duke-NUS Medical School, Singapore)
"Cellular Reprogramming Regulated by Wnt-Cholesterol Pathway"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Wnt Secretion and Receptor Interactions
Discussion Leader: Elizabeth Vincan (University of Melbourne, Australia)
9:00 am - 9:25 am
Rami Hannoush (Genentech, Inc., USA)
"Selective Pharmacological Modulation of Wnt-Receptor Complexes"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Michael Boutros (German Cancer Research Center (DKFZ) / Heidelberg University, Germany)
"The Role of Evi/Wls in Intracellular Wnt Trafficking and Wnt Secretion"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Christopher Arnold (Stowers Institute for Medical Research, USA)
"Wnt and TGF-β Coordinate Growth and Patterning to Give Rise to Size-Dependent Behaviors"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Jean-Paul Vincent (Francis Crick Institute, United Kingdom)
"Mechanism of Long Range Wnt Transport"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Stephanie Grainger (San Diego State University, USA)
"EGFR Is Required for Wnt9a-Fzd9b Signal Activation During Hematopoietic Stem Cell Development"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Rony Chidiac (University of Toronto, Canada)
"Rational Activation of Wnt Signalling Circuits to Promote Directed Differentiation of Human Embryonic Stem Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Melissa Gammons (MRC Laboratory of Molecular Biology, United Kingdom)
"Naked Promotes Wnt/β-Catenin Signalling by Targeting Deactivated Wnt Signalosomes for Autophagy-Dependent Degradation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Tristan Fowler (Surrozen, Inc., USA)
"Fzd-Lrp Bispecific Wnt Stimulating Surrogate Induces Bone Growth"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Alternative Wnt Signaling Pathways
Discussion Leader: Marian Waterman (University of California, Irvine, USA)
7:30 pm - 7:55 pm
Hiroshi Hamada (RIKEN Center for Biosystems Dynamics Research, Japan)
"Role of Wnt-PCP Signaling in Positioning of the Basal Body for Left-Right Symmetry Breaking"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Henry Ho (University of California, Davis, USA)
"Mechanisms of Wnt5a-Ror Signaling in Development and Disease"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Alexandra Schambony (Friedrich-Alexander University Erlangen-Nuremberg, Germany)
"The Wilms Tumour Gene TRIM28 Eencodes a Negative Regulator of Wnt Signaling"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Shane Wright (Karolinska Institutet, Sweden)
"A Conserved Molecular Switch in Class F Receptors Regulates Receptor Activation and Pathway Selection"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Wnt Signaling in Development
Discussion Leader: Mark Peifer (University of North Carolina at Chapel Hill, USA)
9:00 am - 9:25 am
Fabien Le Grand (Sorbonne Université, France)
"Control of Adult Muscle Regeneration by Wnt Signaling Pathways"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Claudia Janda (Princess Maxima Center for Pediatric Oncology, The Netherlands)
"Dissecting the Function of Fzd Subtypes During Bone Development"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Bo Gao (The University of Hong Kong, Hong Kong SAR China)
"A Negative Regulatory Mechanism of Wnt/PCP Signaling by Targeting Vangl Proteins for Ubiquitination and Degradation"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
David Strutt (University of Sheffield, United Kingdom)
"Molecular Dissection of Planar Polarity Signalling Mechanisms in Drosophila "
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Rieko Ajima (National Institute of Genetics, Japan)
"Identification of Wnt5a Downstream Targets During Early Development in Mouse"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Claudio Cantù (Linköping University, Sweden)
"TBX3 Acts as an Activation-Switch of the Beta-Catenin/BCL9 Transcriptional Complex"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Stefan Hoppler (University of Aberdeen, United Kingdom)
"Tissue-Specific Regulation of Direct Wnt Target Genes in Early Embryonic Development"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Athula Wikramanayake (University of Miami, USA)
"Interaction of Casein Kinase 1 Delta/Epsilon and Dishevelled Within Puncta in a Novel Cortical Domain at the Vegetal Pole Specifies Egg and Embryo Polarity in Sea Urchins"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Control of Stem Cells
Discussion Leader: Jean-Paul Vincent (Francis Crick Institute, United Kingdom)
7:30 pm - 7:55 pm
Roeland Nusse (Stanford University, USA)
"Liver Homeostasis and Wnt Signaling"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Nick Barker (Institute of Medical Biology, A*STAR, Singapore)
"Lgr5 Stem Cells in Wnt-Driven Regeneration and Cancer"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Arial Zeng (Chinese Academy of Sciences, China)
"Procr and Wnt Signaling in Regulating Adult Stem Cells"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Irina Matos (The Rockefeller University, USA)
"Progenitors Oppositely Polarize WNT Activators and Inhibitors to Orchestrate Tissue Development"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Wnt Signaling in Disease and Cancer
Discussion Leader: Michael Boutros (German Cancer Research Center (DKFZ) / Heidelberg University, Germany)
9:00 am - 9:25 am
Marian Waterman (University of California, Irvine, USA)
"Wnt Signaling in Stem Cells and Cancer"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Elizabeth Vincan (University of Melbourne, Australia)
"Frizzled7 Functions as a Wnt Receptor in Gastrointestinal Epithelial Stem Cells: Implications for Cancer Growth and Progression"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
David Virshup (Duke-NUS Medical School, Singapore)
"Wnt-Dependent LncRNAs in RNF43-Mutant Pancreatic Cancer"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Stefani Spranger (Massachusetts Institute of Technology, USA)
"The Cross-Talk Between Tumor Cell-Intrinsic Beta-Catenin Activation and Anti-Tumor Immunity"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Dustin Flanagan (Beatson Institute for Cancer Research, United Kingdom)
"The Secreted WNT Inhibitor Notum Is Required by Apc-Mutant Cells for a Competitive Edge over Wildtype Intestinal Stem Cells to Rule the Intestinal Crypt"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Kim Boonekamp (Hubrecht Institute, The Netherlands)
"Identification of Common Wnt Target Genes in Adult Stem Cells"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Helena Rannikmae (University of Cambridge, United Kingdom)
"APC Inactivation in Early Intestinal Tumorigenesis Leads to Compromised Cellular Organisation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Sabine Colnot (INSERM / Centre de Recherche des Cordeliers, France)
"Choline Addiction Enables Imaging of Beta-Catenin-Mutated Hepatocellular Carcinoma and Provides a Therapeutic Target"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Wnt Signaling in Regeneration
Discussion Leader: Claudia Janda (Princess Maxima Center for Pediatric Oncology, The Netherlands)
7:30 pm - 7:55 pm
Thomas Holstein (Heidelberg University, Germany)
"The Cnidarian Wnt Code: Deciphering Early Wnt Ligand-Receptor Interactions"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Renee Van Amerongen (University of Amsterdam, The Netherlands)
"Tissue Specific Regulation of Wnt-Signaling Activity"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Yaron Fuchs (Technion - Israel Institute of Technology, Israel)
"Apoptotic Cells Release Wnt Ligands Driving Stem Cell Proliferation and Skin Regeneration"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Rina Rosin-Arbesfeld (Tel Aviv University, Israel)
"Wnts and Red Blood Cells"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
