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Wnt Signaling

Gordon Research Conference

Wnt Signaling Networks in Development, Disease and Regeneration

August 11 - 16, 2019

Chair

Vice Chairs

and

Mount Snow

89 Grand Summit Way

West Dover, Vermont, United States

Venue and Travel Information

Conference Description

The 2019 Gordon Research Conference titled "Wnt Signaling Networks in Development, Disease and Regeneration” will bring together a diverse group of scientists from around the world with expertise in developmental and stem cell biology, evolution, biochemistry and biophysics, structural biology, cancer research and medicine. Wnt signaling is a highly conserved developmental signaling pathway with pivotal roles in the origin and evolution of all metazoans. Meeting sessions will cover a broad spectrum of biological systems and methodologies with the goal of advancing our understanding of the complex and highly conserved Wnt signaling pathway.

Related Meeting

This GRC will be held in conjunction with the "Wnt Signaling" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Structural Studies of Wnt Signaling Discussion Leader:
7:40 pm - 8:05 pm	"Molecular Mechanisms in Wnt/Beta-Catenin Signal Transduction"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:40 pm	"Structure and Mechanism in the Assembly and Modulation of Wnt Signalling Complexes"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 9:10 pm	"Structure of Wnt Enhanceosome"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Biochemical Reconstitution of Wild-Type and Oncogenic Core β-Catenin Destruction Complexes"
9:25 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Wnt Signal Transduction Discussion Leader:
9:00 am - 9:25 am	"Wnt Regulation of Development and Stem Cell Biology"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Control of Wnt/Beta-Catenin Signaling by the Ubiquitin System"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"The Ubiquitin Ligase HUWE1 Regulates Canonical WNT Signaling Independently of Changes in Beta-Catenin Abundance"
10:20 am - 10:25 am	Discussion
10:25 am - 10:50 am	Coffee Break
10:50 am - 11:15 am	"Mutation-Guided Insights in Wnt Signalling Regulation"
11:15 am - 11:25 am	Discussion
11:25 am - 11:50 am	"Supramolecular Assembly of the Beta-Catenin Destruction Complex and the Effect of Wnt Signaling on Its Localization, Molecular Size and Activity In Vivo"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Structural Consequences of Dishevelled Phosphorylation by CK1 Epsilon"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Single Molecule Dynamics of Dishevelled at the Plasma Membrane and Wnt Pathway Activation"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring. Organizer:
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Control of Gene Expression Discussion Leader:
7:30 pm - 7:55 pm	"Oscillatory Wnt-Signaling Dynamics During Mouse Embryo Development"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	"Sox9 and Wnt Signaling: Two Sides to the Coin"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:05 pm	"The Novel Target Molecule of Wnt/Beta-Catenin Signaling and Cancer"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Cellular Reprogramming Regulated by Wnt-Cholesterol Pathway"
9:25 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Wnt Secretion and Receptor Interactions Discussion Leader:
9:00 am - 9:25 am	"Selective Pharmacological Modulation of Wnt-Receptor Complexes"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"The Role of Evi/Wls in Intracellular Wnt Trafficking and Wnt Secretion"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Wnt and TGF-β Coordinate Growth and Patterning to Give Rise to Size-Dependent Behaviors"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	"Mechanism of Long Range Wnt Transport"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"EGFR Is Required for Wnt9a-Fzd9b Signal Activation During Hematopoietic Stem Cell Development"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Rational Activation of Wnt Signalling Circuits to Promote Directed Differentiation of Human Embryonic Stem Cells"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Naked Promotes Wnt/β-Catenin Signalling by Targeting Deactivated Wnt Signalosomes for Autophagy-Dependent Degradation"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Fzd-Lrp Bispecific Wnt Stimulating Surrogate Induces Bone Growth"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Alternative Wnt Signaling Pathways Discussion Leader:
7:30 pm - 7:55 pm	"Role of Wnt-PCP Signaling in Positioning of the Basal Body for Left-Right Symmetry Breaking"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	"Mechanisms of Wnt5a-Ror Signaling in Development and Disease"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:05 pm	"The Wilms Tumour Gene TRIM28 Eencodes a Negative Regulator of Wnt Signaling"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"A Conserved Molecular Switch in Class F Receptors Regulates Receptor Activation and Pathway Selection"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Wnt Signaling in Development Discussion Leader:
9:00 am - 9:25 am	"Control of Adult Muscle Regeneration by Wnt Signaling Pathways"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Dissecting the Function of Fzd Subtypes During Bone Development"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"A Negative Regulatory Mechanism of Wnt/PCP Signaling by Targeting Vangl Proteins for Ubiquitination and Degradation"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	"Molecular Dissection of Planar Polarity Signalling Mechanisms in Drosophila"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Identification of Wnt5a Downstream Targets During Early Development in Mouse"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"TBX3 Acts as an Activation-Switch of the Beta-Catenin/BCL9 Transcriptional Complex"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"Tissue-Specific Regulation of Direct Wnt Target Genes in Early Embryonic Development"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Interaction of Casein Kinase 1 Delta/Epsilon and Dishevelled Within Puncta in a Novel Cortical Domain at the Vegetal Pole Specifies Egg and Embryo Polarity in Sea Urchins"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Control of Stem Cells Discussion Leader:
7:30 pm - 7:55 pm	"Liver Homeostasis and Wnt Signaling"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	"Lgr5 Stem Cells in Wnt-Driven Regeneration and Cancer"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:05 pm	"Procr and Wnt Signaling in Regulating Adult Stem Cells"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Progenitors Oppositely Polarize WNT Activators and Inhibitors to Orchestrate Tissue Development"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Wnt Signaling in Disease and Cancer Discussion Leader:
9:00 am - 9:25 am	"Wnt Signaling in Stem Cells and Cancer"
9:25 am - 9:35 am	Discussion
9:35 am - 10:00 am	"Frizzled7 Functions as a Wnt Receptor in Gastrointestinal Epithelial Stem Cells: Implications for Cancer Growth and Progression"
10:00 am - 10:10 am	Discussion
10:10 am - 10:20 am	"Wnt-Dependent LncRNAs in RNF43-Mutant Pancreatic Cancer"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:20 am	"The Cross-Talk Between Tumor Cell-Intrinsic Beta-Catenin Activation and Anti-Tumor Immunity"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"The Secreted WNT Inhibitor Notum Is Required by Apc-Mutant Cells for a Competitive Edge over Wildtype Intestinal Stem Cells to Rule the Intestinal Crypt"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Identification of Common Wnt Target Genes in Adult Stem Cells"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:10 pm	"APC Inactivation in Early Intestinal Tumorigenesis Leads to Compromised Cellular Organisation"
12:10 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Choline Addiction Enables Imaging of Beta-Catenin-Mutated Hepatocellular Carcinoma and Provides a Therapeutic Target"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Wnt Signaling in Regeneration Discussion Leader:
7:30 pm - 7:55 pm	"The Cnidarian Wnt Code: Deciphering Early Wnt Ligand-Receptor Interactions"
7:55 pm - 8:05 pm	Discussion
8:05 pm - 8:30 pm	"Tissue Specific Regulation of Wnt-Signaling Activity"
8:30 pm - 8:40 pm	Discussion
8:40 pm - 9:05 pm	"Apoptotic Cells Release Wnt Ligands Driving Stem Cell Proliferation and Skin Regeneration"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Wnts and Red Blood Cells"
9:25 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Funding for this conference was made possible (in part) by 1R13 HD097874-01 from the National Institutes of Health, National Heart, Lung and Blood Institute. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention of trade names, commercial practices, or organizations imply endorsement by the U.S. Government.

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