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Wnt Signaling

Gordon Research Conference

Molecular Mechanisms, Embryonic Development and Adult Tissue Homeostasis and Therapeutics

July 30 - August 4, 2023

Chairs

and

Vice Chairs

and

Rey Don Jaime Grand Hotel

Avinguda de l'Hotel

Castelldefels, Barcelona, Spain

Venue and Travel Information

Conference Description

The Wnt Signaling GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Wnt signaling is an evolutionary conserved cell-cell communication system directing embryonic development and adult tissue homeostasis. Wnt proteins are involved in tissue regeneration after injury and deregulated signaling promote cancer and other human diseases. The 2023 Wnt Signaling GRC and GRS will bring together established and emerging scientists interested in all aspects of Wnt biology: the molecular mechanisms underlying signal transduction, the biological processes controlled by Wnt signaling and the various diseases rooted in aberrant Wnt signaling. Academic scientists, clinicians and industry leaders will discuss advances in Wnt signaling that impact their fields of interest. Speakers will present recent findings based on a variety of experimental approaches and model systems, with the goals of stimulating discussions, pushing the field’s boundaries, forging new collaborations and promoting the emergence of new leaders in this field.

Related Meeting

This GRC will be held in conjunction with the "Wnt Signaling" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Structure and Function of Wnt Signaling Discussion Leader:
7:40 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:10 pm	"Molecular Mechanisms of the Beta-Catenin Destruction Complex and Its Regulation by Tankyrase"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:40 pm	"Structural Insights into the Extracellular Modulation of Wnt Signalling"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 9:20 pm	"Dissecting the Wnt Pathway in Cancer and Tissue Regeneration: A Molecular and Pharmacological Perspective"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Mechanisms of Wnt Signal Transduction Discussion Leader:
9:00 am - 9:25 am	"Regulation of Beta-Catenin Signaling at the Cell Surface"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Structural Insights into Wnt Signalosome Assembly"
9:40 am - 9:45 am	Discussion
9:45 am - 9:55 am	"Structure of the Wnt-Frizzled-LRP6 Initiation Complex Reveals the Basis for Coreceptor Discrimination"
9:55 am - 10:00 am	Discussion
10:00 am - 10:25 am	"GSK3 and AP-2 Clathrin Adaptor Synergize to Nucleate Wnt Signalosome Assembly at the LRP6 Co-Receptor"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"Oncogenic Transcription Difference Between Wnt Signal-Activated Hepatocellular Carcinoma and Colorectal Carcinoma"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Multivalent Interactions Between the DIX domain and Intrinsically Disordered Regions of AXIN1 Provide a Tunable System for ß-catenin Destruction Complex Assembly, Dynamics and Activity"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"N-Glycosylation of LRP6 by B3GnT2 Promotes Wnt/ß-catenin Signaling"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:25 pm	"Tissue-Specific Initiation and Interpretation of WNT/CTNNB1 Signaling"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Wnt Signaling in Diseases Discussion Leader:
6:00 pm - 6:25 pm	"WNTLESSness in Zaki Syndrome is Druggable with a Small Molecule WNT Agonist"
6:25 pm - 6:30 pm	Discussion
6:30 pm - 6:55 pm	"Wnt Inhibitor ZNRF3 in Aging and Cancer"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:10 pm	"TBX3 Orchestrates a WNT/Beta-Catenin-Dependent Transcriptional Program in Metastatic Colorectal Cancer"
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"CK1-DVL Complex Formation: To Be or Not to Be (Auto)phosphorylated?"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:55 pm	"Finding Novel Targets Downstream of Ligand Independent Wnt Pathway Mutations in Intestine and Liver Cancer"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Wnt Signaling in Tissue Homeostasis and Organoids Discussion Leader:
9:00 am - 9:25 am	"WNT Signal Targeting and Intestinal Bioengineering"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Building Brains for Sensory Perception"
9:40 am - 9:45 am	Discussion
9:45 am - 10:10 am	"Unravelling the Molecular Mechanisms of Neural Patterning and Generation of Dopamine Neurons using Antibodies Targeting Wnt Receptors"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Intercellular Exchange of Wnt Ligands Reduces Heterogeneity in the Neuromesodermal Progenitor Cell Population and Enhances its Robustness"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"Leveraging Organoids to Dissect the Role of the Circadian Clock in Cancer"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	"A Signalling Rheostat Controls Chromosome Segregation Fidelity During Neurogenesis"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"Microtubule Anchoring of Axin Counteracts Wnt Pathway Activation"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:25 pm	"Organoids Model Human Disease"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Wnt Signaling in Development Discussion Leader:
6:00 pm - 6:25 pm	"Wnt Signaling Pathways and the Regulation of Axial Progenitors"
6:25 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 7:10 pm	"Modeling Robinow Syndrome in the Mouse"
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:25 pm	"Role of Arf6 in Wingless Signalling Pathway During Drosophila wing Development"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:55 pm	"SOX Transcription Factors Regulate Genomic Specificity of WNT-Responsive Gene Expression"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	ßcatenin-Independent Signaling Discussion Leader:
9:00 am - 9:25 am	"Wnt/Planar Cell Polarity Signaling in Vertebrate Development and Disease"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Post-Translational Regulation of Wnt/PCP Signaling"
9:40 am - 9:45 am	Discussion
9:45 am - 10:10 am	"C-Terminal Elongation of DVL3 by Polyglutamylation Controls its Liquid-Liquid Phase Separation and Function in the Non-Canonical Wnt Pathway"
10:10 am - 10:15 am	Discussion
10:15 am - 10:45 am	Coffee Break
10:45 am - 11:10 am	"Multiscale Coordination of Planar Cell Polarity"
11:10 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Reconstructing Asymmetric Intercellular Complex Formation in Planar Polarity"
11:25 am - 11:30 am	Discussion
11:30 am - 11:55 am	"Age Against the Machine: How Aging Promotes Tumor Progression"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:25 pm	"Wnt Regulation of MAPK Signaling – The Lipid Connection"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Wnt Secretion, Regulation of Gene Expression and Nuclear Mechanisms Discussion Leader:
6:00 pm - 6:25 pm	"Secretion of Wnt Proteins During Development and in Cancer"
6:25 pm - 6:30 pm	Discussion
6:30 pm - 6:55 pm	"Logistics of Wnt Production and Transport"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:10 pm	"Understanding Glypican-based Mechanisms of Extracellular Wnt Distribution"
7:10 pm - 7:15 pm	Discussion
7:15 pm - 7:50 pm	"Wnt Signaling in Stem Cells and Cancer"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Therapeutic Targeting of Wnt Signaling Discussion Leader:
9:00 am - 9:25 am	"Targeting WNT in Cancer: Why, When, Where, and How"
9:25 am - 9:30 am	Discussion
9:30 am - 9:40 am	"Targeting the Wnt Signaling Modulator DKK1 for Oncology"
9:40 am - 9:45 am	Discussion
9:45 am - 10:10 am	"Efficacy of a Frizzled4/LRP5 Agonist in Retinal Vascular Disease Models"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Wnt-mimetic ANTibodies for Regenerative Therapy"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:25 am	"Molecular Insights into Wnt Biogenesis"
11:25 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Porcupine (PORCN) Inhibition to Treat Lung Fibrosis"
11:40 am - 11:45 am	Discussion
11:45 am - 11:55 am	"PROTABs: A Tool for Leveraging E3 Ubiquitin Ligases as Cell Surface Protein Degraders"
11:55 am - 12:00 pm	Discussion
12:00 pm - 12:25 pm	"Targeting FZD7 in Development and Cancer"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:30 pm	Free Time
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 8:00 pm	Wnt Signaling in Stem Cells and Tissue Regeneration Discussion Leader:
6:00 pm - 6:25 pm	"Wnt-Dependent Master Regulators Controlling Pluripotency and Early Mouse Development"
6:25 pm - 6:30 pm	Discussion
6:30 pm - 6:40 pm	"Single-cell RNA-seq Analysis of Wnt Regulation of Human Heart Muscle Differentiation"
6:40 pm - 6:45 pm	Discussion
6:45 pm - 6:55 pm	"Telocytes are a Critical Source of Wnts Essential for Hair Follicle Regeneration"
6:55 pm - 7:00 pm	Discussion
7:00 pm - 7:25 pm	"Wnt Signaling in Whole-Body Regeneration"
7:25 pm - 7:30 pm	Discussion
7:30 pm - 7:55 pm	"Harnessing Adult Stem Cells for Pancreatic Islet Regeneration"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institutes of Health under Award Number R13HD105309. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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