Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Historical Perspectives on Wnt Signaling
3:45 pm - 4:15 pm
"Wnt Signaling: How Our Understanding Evolved During the Past 20 Years"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
7:30 pm - 7:40 pm
"Phosphorylation of the Dishevelled DEP Domain Negatively Regulates Domain-Swapping, Inhibiting Canonical Wnt/β-Catenin Dependent Transcription"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Arginine Methylation Is Required for Wnt Signaling and Lysosomal Trafficking"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Proteomic Analysis Identifies the E3 Ubiquitin Ligase PDZRN3 as a Regulatory Target of WNT5A-ROR Signaling"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Fluorescent Labeling of Endogenous Tcf/Lefs Allows for the Investigation of Their Exchange During Differentiation and Their Roles in Pluripotency"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Dally Like Reguates Activities of Wnts in the Drosophila Germarium"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"PLEKHA4/Kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Dissection of Wnt Secretion In Vivo Through the Use of Endogenously Tagged Drosophila Wg and Evi/Wls Proteins"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Mapping Synthetic Lethal Interactions in the Wnt/β-Catenin Pathway"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Wnt Signaling in Development and Disease
9:00 am - 9:10 am
"Deciphering Wnt-Dependent Mechanisms of Age-Related Intestinal Stem Cell Exhaustion by Single-Cell Genomics"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
"Wnt and TGF-β Coordinate Growth and Patterning to Give Rise to Size-Dependent Behaviors"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
"Identification, Characterisation and Therapeutic Targeting of a Novel Tumour-Promoting Signalling Axis: RYK/WNT Signalling"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
"Mouse Models for Wnt-Signaling-Dependent Liver Carcinogenesis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
"Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
"Quadruple Wnt Mutants Show that PCP Is Established in the Absence of a Wnt Gradient"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
"Rspo1 Everexpression Induces Sex Specific Hyperplasia and Tissue Degeneration in the Adrenal Cortex"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
"Modelling Wnt-Driven Liver Zonation In Vitro "
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Discussion Panel
1:30 pm - 2:30 pm
Panel Discussion
Scientific Careers in Wnt
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
