Saturday
2:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Historical Perspectives on Wnt Signaling
Discussion Leader: Saskia de Man (Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands)
3:45 pm - 4:15 pm
Michael Boutros (German Cancer Research Center (DKFZ) / Heidelberg University, Germany)
"Wnt Signaling: How Our Understanding Evolved During the Past 20 Years"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Wnt Signaling Mechanisms
Discussion Leaders: Madelon Maurice (University Medical Center Utrecht, The Netherlands) and Zachary DeBruine (Van Andel Research Institute, USA)
7:30 pm - 7:40 pm
Gonzalo Beitia (MRC Laboratory of Molecular Biology, United Kingdom)
"Phosphorylation of the Dishevelled DEP Domain Negatively Regulates Domain-Swapping, Inhibiting Canonical Wnt/β-Catenin Dependent Transcription"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
Lauren Albrecht (University of California, Los Angeles, USA)
"Arginine Methylation Is Required for Wnt Signaling and Lysosomal Trafficking"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
Sara Konopelski (University of California, Davis, USA)
"Proteomic Analysis Identifies the E3 Ubiquitin Ligase PDZRN3 as a Regulatory Target of WNT5A-ROR Signaling"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
Victor Gordon (McMaster University, Canada)
"Fluorescent Labeling of Endogenous Tcf/Lefs Allows for the Investigation of Their Exchange During Differentiation and Their Roles in Pluripotency"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Indrayani Waghmare (Vanderbilt University, USA)
"Dally Like Reguates Activities of Wnts in the Drosophila Germarium"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Adnan Shami Shah (Cornell University, USA)
"PLEKHA4/Kramer Attenuates Dishevelled Ubiquitination to Modulate Wnt and Planar Cell Polarity Signaling"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Bojana Pavlovic (German Cancer Research Center (DKFZ), Germany)
"Dissection of Wnt Secretion In Vivo Through the Use of Endogenously Tagged Drosophila Wg and Evi/Wls Proteins"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Siobhan O'Brien (University of Toronto, Canada)
"Mapping Synthetic Lethal Interactions in the Wnt/β-Catenin Pathway"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Wnt Signaling in Development and Disease
Discussion Leaders: Karl Willert (University of California, San Diego, USA) and Odemaris Narvaez del Pilar (Graduate School of Biomedical Sciences, University of Texas MD Anderson Cancer Center, USA)
9:00 am - 9:10 am
Maja Funk (German Cancer Research Center, Germany)
"Deciphering Wnt-Dependent Mechanisms of Age-Related Intestinal Stem Cell Exhaustion by Single-Cell Genomics"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Christopher Arnold (Stowers Institute for Medical Research, USA)
"Wnt and TGF-β Coordinate Growth and Patterning to Give Rise to Size-Dependent Behaviors"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
James Roy (Peter MacCallum Cancer Centre, Australia)
"Identification, Characterisation and Therapeutic Targeting of a Novel Tumour-Promoting Signalling Axis: RYK/WNT Signalling"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Robin Loesch (DRPA06, INSERM, France)
"Mouse Models for Wnt-Signaling-Dependent Liver Carcinogenesis"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Emma Schatoff (Weill Cornell Medicine, USA)
"Distinct Colorectal Cancer-Associated APC Mutations Dictate Response to Tankyrase Inhibition"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Joy Sze Yu (The Francis Crick Institute, United Kingdom)
"Quadruple Wnt Mutants Show that PCP Is Established in the Absence of a Wnt Gradient"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Rodanthi Lyraki (Institute of Biology Valrose, Université Nice Sophia Antipolis, France)
"Rspo1 Everexpression Induces Sex Specific Hyperplasia and Tissue Degeneration in the Adrenal Cortex"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Eider Valle-Encinas (Cardiff University, United Kingdom)
"Modelling Wnt-Driven Liver Zonation In Vitro "
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Discussion Panel
Discussion Leader: Pooja Sonavane (University of California, San Diego, USA)
1:30 pm - 2:30 pm
Panel Discussion
Scientific Careers in Wnt
Ken Cadigan (University of Michigan, USA)
Claudia Janda (Princess Maxima Center for Pediatric Oncology, The Netherlands)
Elizabeth Vincan (University of Melbourne, Australia)
2:30 pm - 3:00 pm
Evaluation Period
Fill in GRS Evaluation Forms
3:00 pm
Seminar Concludes
