Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:00 pm - 3:15 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm
Keynote Session: An Updated Overview of Wnt Signaling
Discussion Leader: Cornelia Redel (Deutsches Krebsforschungszentrum (DKFZ), Germany)
3:15 pm - 3:50 pm
Karl Willert (University of California, San Diego, United States)
"An Updated Overview of Wnt Signaling"
3:50 pm - 4:00 pm
Discussion
4:00 pm - 5:30 pm
Poster Session
5:30 pm - 7:30 pm
Wnt Signaling: From Mechanisms to Therapeutics
Discussion Leader: Saira Sakalas (The Institute of Cancer Research, United Kingdom)
5:30 pm - 5:40 pm
Mohua Das (Genome Institute of Singapore, Singapore)
"Investigating ß-Cat-Responsive Transcription (CRT) Inhibitors to Remodel Tumour-Immune Microenvironment in Colorectal Cancer"
5:40 pm - 5:45 pm
Discussion
5:45 pm - 5:55 pm
Tomasz Radaszkiewicz (Masaryk University, Czech Republic)
"Polarity and Proximity: BioID-Based Mapping of Wnt/PCP Interactome and its Functional Analysis"
5:55 pm - 6:00 pm
Discussion
6:00 pm - 6:10 pm
Antonia Schubert (Deutsches Krebsforschungszentrum, Germany)
"Regulators of Dvl2 Localization to Wnt-Dependent Biomolecular Condensates"
6:10 pm - 6:15 pm
Discussion
6:15 pm - 6:25 pm
Arthur Sim (National University of Singapore, Singapore)
"ETC-159, an Upstream Wnt Inhibitor, Induces Tumour Necrosis via Modulation of Angiogenesis in Osteosarcoma"
6:25 pm - 6:30 pm
Discussion
6:30 pm - 6:40 pm
Joep Sprangers (UMC Utrecht, The Netherlands)
"WNT7B Drives a Program for Pancreatic Cancer Subtype Switching and Progression"
6:40 pm - 6:45 pm
Discussion
6:45 pm - 6:55 pm
Jill Zimmerman (Weill Cornell Medicine, United States)
"Tumor Selective WNT Suppression in Colorectal Cancer"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:10 pm
Tyler Hoard (University of Michigan, United States)
"Identification of Semaphorin Receptors as Novel WNT Pathway Antagonists"
7:10 pm - 7:15 pm
Discussion
7:15 pm - 7:25 pm
Lucie Wolf (Donnelly Centre, University of Toronto, Canada)
"An Induced Protein Proximity Screen to Identify Regulators of Wnt Signaling in Colorectal Cancer"
7:25 pm - 7:30 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Wnt Signaling in Stem Cell Biology and Regenerative Medicine
Discussion Leader: David Willnow (Francis Crick Institute, United Kingdom)
9:00 am - 9:10 am
Benjamin Broadway (The Institute Of Cancer Research, United Kingdom)
"CRISPR Base Editor Scanning Marks Essential Factors for Tankyrase Activity"
9:10 am - 9:15 am
Discussion
9:15 am - 9:25 am
Pierfrancesco Pagella (Linköping University, Sweden)
"The Time-Resolved Genomic Impact of Wnt/ß-Catenin Signalling"
9:25 am - 9:30 am
Discussion
9:30 am - 9:40 am
Minako Suzuki (National Institute for Basic Biology, Japan)
"Dynamic Cooperation of Heparan Sulfate Proteoglycans with Wnt11 and Core PCP Components in the Regulation of Planar Cell Polarity"
9:40 am - 9:45 am
Discussion
9:45 am - 9:55 am
Nydia Tejeda Munoz (UCLA, United States)
"Wnt Signaling in Membrane Trafficking and Cell Adhesion"
9:55 am - 10:00 am
Discussion
10:00 am - 10:10 am
Shruti Tophkhane (University of British Columbia, Canada)
"Robinow Syndrome Associated Frizzled2 Mutations Alter Skeletogenesis and WNT Pathway in the Face"
10:10 am - 10:15 am
Discussion
10:15 am - 10:25 am
Abdu Alsaadi (Harvard Medical School, United States)
"Single Cell Transcriptomics identifies a WNT7A-FZD5 Signaling Axis that Maintains Fallopian Tube Stem Cells in Patient-Derived Organoids"
10:25 am - 10:30 am
Discussion
10:30 am - 10:40 am
Kelsey Carpenter (Van Andel Institute, United States)
"Dvl Specificity Required for Hematopoietic Stem Cell Development"
10:40 am - 10:45 am
Discussion
10:45 am - 10:55 am
Hongyu Shao (the University of Sheffield, United Kingdom)
"The Planar Polarity Regulator Casein Kinase Ie is Asymmetrically Distributed within Cells Colocalising With its Molecular Target Dishevelled"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: How to Have a Successful Career in Research
Discussion Leader: Indrayani Waghmare (Vanderbilt University, United States)
1:30 pm - 2:30 pm
Panel Discussion
How to Have a Successful Career in Research
Stephanie Grainger (Van Andel Institute, United States)
Claudio Cantù (Linköping University, Sweden)
Madelon Maurice (University Medical Center Utrecht, The Netherlands)
Feng Cong (Novartis Institutes for BioMedical Research, United States)
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
