Sunday PM / Monday AM: |
Growth factors |
Chair: Sabine Werner, Max-Planck-Institut für Biochemie, Martinsried
- Sabine Werner - Novel growth factor-regulated genes and their roles in wound repair
- Helen Blau - (Stanford University School of Medicine) - Increased vascularization in non-ischemic adult muscle following implantation of myoblasts constitutively expressing high levels of VEGF
- Gary Grotendorst - (University of Miami Medical School) - Mechanism for CTGF mediated TGF-beta effects on fibroblasts
- * Alan Wells - (University of Alabama at Birmingham) - Growth factor modulation of de-adhesion in fibroblast motility
- * Ingrid Blom - (University Hospital, Ultrecht) - Connective tissue growth factor induces increased migration of rat mesangial cells in culture
Monday AM: |
Cell adhesion, growth, and survival |
Chair: Rick Assoian, University of Pennsylvania School of Medicine
- Rick Assoian - Control of G1 phase cell cycle progression in fibroblasts by cell adhesion to extracellular matrix
- Lucia Languino - (Yale University) - Modulation of cell proliferation by the integrin cytoplasmic domain
- * Livingston Van de Water - (MGH/Harvard Medical School) - Sequences within the EIIIA (ED-A) segment of fibroblasts implicated in regulating fibroblast activation during wound healing
- * William Carter - (Fred Hutchinson Cancer Research Center) - Adhesion of keratinocytes and gap junctional communication: Implications for wound repair
- * Lawrence T. Kim - (VA Hospital Dallas/UT Southwestern) - Integrin-dependent signaling is enabled during keratinocyte activation
- * Brian K. Pilcher - (Washington University School of Medicine) - Differential expression of transcripts in keratinocytes following contact with type I collagen: A model of keratinocyte activation and
differentiation following epidermal injury
Monday PM / Tuesday AM: |
Fibrosis |
Chair: Joseph Korn, Boston University School of Medicine
- Joseph Korn - Cellular and molecular basis of a profibrotic phenotype in dermal fibroblasts
- Jack Gauldie - (McMaster University, Ontario) - Cytokine gene transfer in models of fibrogenesis
- Richard Bucala - (Picower Institute for Medical Research, Manhasset) - Fibrocytes: Circulating fibroblast-like cells that present antigen and mediate tissue repair
- * Giulio Gabbiani - (Universite de Geneve) - Mechanisms regulating fibroblast alpha-smooth muscle actin expression and polymerization
- * Ken Cutroneo - (University of Vermont) - Phosphorothioate oligodeoxynucleotides, a novel class of antifibrotic drugs that mimic glucocorticoids
Tuesday AM: |
Extracellular matrix |
Chair: Jean Schwarzbauer, Princeton University
- Jean Schwarzbauer - Extracellular matrix modulation of cell behavior
- Bill Parks - (Washington University School of Medicine) - Interactions between MMP's, matrix, and matrix receptors during epithelization
- Deane Mosher - (University of Wisconsin) - Lysophosphatidic acid and sphingosine-1-phosphate: Serum mediators of extracellular matrix organization
- * Gabriella Skuta - (UT Southwestern) - Uncoupling collagen matrix contraction and increased myosin light chain phosphorylation
- * Claire Johnson - (Pfizer Central Research, Sandwich, Kent, UK) - Gene expression profiling of wound healing in keratinocytes using DNA microarrays
Tuesday PM / Wednesday AM: |
Mechanoregulation |
Chair: Paul McNeil, Medical College of Georgia
- Paul McNeil - Mechanical wounding at the cellular level
- Richard Lee - (Harvard Medical School) - Mechanically induced genes in vascular smooth muscle
- Don Ingber - (Harvard Medical School) - The architecture of life
- * Maddy Parsons - (University College, London) - Mechanical load and growth factors alter dermal fibroblast cell-surface expression of alpha1 and alpha2 integrin subunits: Role in regulating procollagen
synthesis
- * Beate Eckes - (Department of Dermatology, Cologne, Germany) - Gene regulation by mechanical forces in human dermal fibroblasts
Wednesday AM: |
Healing in the nervous system |
Chair: Rick Morrison, University of Washington, Seattle
- Rick Morrison - Cell death signaling pathways in neurons
- Ron McKay - (NIH) - Reconstructing the Brain
- Ann Logan - (University of Birmingham, UK) - Attenuation of glial scarring in the injured CNS by inhibition of TGF-beta activity
- * Rivkah Isseroff - (University of California, Davis) - Epidermal growth factor receptor relocalization and kinase activity are necessary for directional migration of keratinocytes in DC electric fields
- * Mark Walker - (University of Ulster, UK) - Effect of transcutaneous electrical nerve stimulation upon a radiation impaired wound healing model in murine skin
Wednesday PM / Thursday AM: |
Development, repair, and regeneration |
Chair: Paul Martin, University College London
- Paul Martin - Mechanisms of repair in the embryo
- Clive Wilson - (University of Kent, UK) - Regulation of cell shape and movement in Drosophila
- Martin Cohn - (University of Reading, UK) - Molecular control of vertebrate limb development
- Ellen Heber-Katz - (Wistar Institute) - Evidence supporting a mouse model of regeneration
Thursday AM: |
Analysis of repair with transgenics and conditional knockouts |
Chair: Pierre Coulombe, Johns Hopkins University School of Medicine
- Pierre Coulombe - Keratin genes, their proteins, and wound re-epithelization
- Gillian Ashcroft - (NIH/University of Manchester, UK) - Wound healing in p21 knock-out mice
- Thomas Braun - (Technical University of Baunschweig, Germany) - Analysis of skeletal muscle regeneration by myogenic transcription factors and FGFs
- * Michael Detmar - (Harvard Medical School) - Wound healing in thrombospondin-1 transgenic mice
- * Pyong Woo Park - (Children's Hospital/Harvard Medical School) - Role of syndecan-1 shedding in bacterial pathogenesis
Thursday PM: |
Keynote lecture |
Chair: Joe Leibovich, UMDNJ New Jersey Medical School
- Anita Roberts - (NCI, NIH) - TGF-beta
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