| SUNDAY |
| 4:00 pm - 8:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:45 pm) |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Keynote Lecture |
| 7:40 pm - 8:00 pm | Discussion Leader: Fulton Crews (University of North Carolina at Chapel Hill)
|
| 8:00 pm - 9:00 pm | George Koob (National Institute on Alcohol Abuse and Alcoholism)
"Neurobiology of Alcoholism: A Reward Deficit, Stress Surfeit, Executive System Disorder"
|
| 9:00 pm - 9:30 pm | Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | Structural and Functional Plasticity |
| 9:00 am - 9:10 am | Discussion Leader: Judson Chandler (Medical University of South Carolina)
"Introduction"
|
| 9:10 am - 9:30 am | Garret Stuber (University of North Carolina at Chapel Hill)
"Neural Circuit Function and Adaptation that Underlies Motivated Behaviors: Implications for Substance Abuse"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Veronica Alvarez (National Institute on Alcohol Abuse and Alcoholism)
"Striatal Pathways Affected and Involved in Voluntary Ethanol Drinking" |
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:40 am | Coffee Break |
| 10:40 am - 11:00 am | Segev Barak (Tel Aviv University)
"Preventing Relapse in Alcoholism: From Synaptic Protein Synthesis to Memory Plasticity" |
| 11:00 am - 11:10 am | Discussion |
| 11:10 am - 11:30 am | Thomas Kash (University of North Carolina at Chapel Hill)
"NPY Modulation of CRF Neurons: Implications for Alcohol Drinking"
|
| 11:30 am - 11:40 am | Discussion |
| 11:40 am - 11:50 am | Breaking News: Jiang-Hong Ye (Rutgers University)
"The Role of the Lateral Habenula in Alcohol Addiction"
|
| 11:50 am - 11:55 am | Discussion |
| 11:55 am - 12:05 pm | Breaking News: Woody Hopf (Gallo Research Center, UCSF)
"Cortico-Accumbens Circuits and NMDAR Plasticity Mediates Punishment-Resistant Alcohol Intake"
|
| 12:05 pm - 12:10 pm | Discussion |
| 12:10 pm - 12:20 pm | Breaking News: Beate Finger (Harvard Medical School)
"A Functional Dissociation Within the Insular Cortex Contributes to the Regulation of Impulsive Decision-Making Dependent on Innate Impulsive Traits"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Basal Ganglia Circuitry |
| Discussion Leader: Brian Mathur (University of Maryland) |
| 7:30 pm - 7:50 pm | Emmanuel Valjent (Institut de Génomique Fonctionnelle)
"New Insights into the Anatomo-Functional Organization of Striatal Medium-Sized Spiny Neurons"
|
| 7:50 pm - 8:00 pm | Discussion |
| 8:00 pm - 8:20 pm | Henry Yin (Duke University)
"The Role of Opponent Basal Ganglia Outputs in Behavior"
|
| 8:20 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:50 pm | Patricia Janak (University of California San Francisco)
"Striatal Subregions and Alcohol Addiction"
|
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:10 pm | Breaking News: Xin Jin (The Salk Institute)
"Functional Dissection of Corticostriatal Subcircuits by Mono-Trans-Synaptic Tracing and Manipulation"
|
| 9:10 pm - 9:15 pm | Discussion |
| 9:15 pm - 9:25 pm | Breaking News: Angela Ozburn (University of Pittsburgh, Medical School)
"Effects of Pharmacogenetic Manipulation of the Nucleus Accumbens on Neuronal Activity and Alcohol-Related Behaviors"
|
| 9:25 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Alcohol and the Brain Stress System |
| 9:00 am - 9:10 am | Discussion Leader: Antonio Noronha (National Institute on Alcohol Abuse and Alcoholism)
"Introduction"
|
| 9:10 am - 9:30 am | Marisa Roberto (Scripps Research Institute)
"Synaptic Mechanisms of Ethanol and Neuropeptides in Central Amygdala"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Brian McCool (Wake Forest University)
"Independent Glutamatergic Synapses in Basolateral Amygdala Express Unique Responses to Ethanol Dependence: A Role for Associative Heterosynaptic Plasticity in Persistent Withdrawal Behaviors?"
|
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Rainer Spanagel (University of Heidelberg)
"The Role of Glucocorticoid Receptor Function in Compulsive Alcohol Consumption"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Todd Thiele (University of North Carolina)
"Recruitment of Neuropeptide Y and Corticotropin Releasing Factor During Binge Ethanol Drinking: Mechanisms Underlying the Transition to Ethanol Dependence?"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Amy Milton (University of Cambridge)
"Targeting Reconsolidation for the Treatment of Alcoholism" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Breaking News: Tracy Butler (Wake Forest School of Medicine)
"Social Isolation Engenders an Addiction-Like Phenotype in Male, but not Female, Long Evans Rats Relative to Group Housed Counterparts"
|
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Breaking News: Kathryn Harper (Northwestern University)
"Maternal Alcohol Consumption During Pregnancy Affects Second-Generation Progeny in a Genotype- and Sex-Dependent Manner"
|
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Alcohol Effects on Neural Development |
| 7:30 pm - 7:40 pm | Discussion Leader: Edward Riley (San Diego State University)
"Introduction"
|
| 7:40 pm - 8:00 pm | Fernando Valenzuela (University of New Mexico)
"Novel Insights into the Effect of Developmental Ethanol Exposure on the Hippocampus"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | Alexandre Medina (University of Maryland)
"Improving Cortical Neuronal Plasticity in a Model of Fetal Alcohol Spectrum Disorders"
|
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:00 pm | Rajesh Miranda (Texas A&M University)
"MicroRNAs: Biomarkers and Mediators of Fetal Alcohol Effects"
|
| 9:00 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:20 pm | Breaking News: Anita Majewska
"Microglia and Developmental Alcohol Exposure: Implications for Synaptic Development" |
| 9:20 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Molecular Signaling and Cross Talk |
| 9:00 am - 9:10 am | Discussion Leader: Robert Messing (University of Texas at Austin)
"Introduction"
|
| 9:10 am - 9:30 am | Adron Harris (University of Texas at Austin)
"Alcohol Binding Sites on Proteins: Atomic Resolution"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Danny Winder (Vanderbilt University)
"Targeted Proteomic Analysis Predicts Ethanol Regulation of Synaptic Plasticity"
|
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Andrew Tapper (University of Massachusetts)
"Nicotinic Receptor Signaling in Alcohol-Mediated Activation of Dopaminergic Neurons"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Wolfgang Sommer (CIMH)
"Scars in the mPFC: Profiling Transcriptomic, Metabolomic and Connectomic Responses to Understand Executive Deficits in Alcohol Abstinence"
|
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Loren Parsons (Scripps Research Institute)
"Impaired Endocannabinoid Signaling Contributes to Withdrawal-Related Anxiety and Excessive EtOH Consumption"
|
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Breaking News: Ryan Vetreno (University of North Carolina at Chapel Hill)
"Involvement of the Neuroimmune System in Alcohol-Induced Reductions of Neurogenesis and Cholinergic Cell Populations"
|
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Breaking News: Yolanda Pena-Oliver (University of Cambridge)
"Alcohol-Preferring P and Non-Preferring NP Rats Do Not Differ in Motor Impulsivity but Display Dramatic Differences in Goal/Sign Tracking Behavior"
|
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
| 7:30 pm - 9:30 pm | Genetic Basis of Alcohol's Neural Actions |
| 7:30 pm - 7:40 pm | Steven Treistman (University of Puerto Rico)
"Introduction"
|
| 7:40 pm - 8:00 pm | Igor Ponomarev (University of Texas at Austin)
"Molecular Signatures of Excessive Alcohol Consumption"
|
| 8:00 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:30 pm | David Goldman (National Institute on Alcohol Abuse and Alcoholism)
"A Grm2 Stop Codon in the Alcohol Preferring (P) Rat and Wistar Parental Strain"
|
| 8:30 pm - 8:40 pm | Discussion |
| 8:40 pm - 9:00 pm | Adrian Rothenfluh (University of Texas Southwestern Medical Center)
"S6 Kinase is a Key Mediator of Ethanol-Induced Behaviors"
|
| 9:00 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:20 pm | Breaking News: Warnault Vincent (Gallo Research Center, UCSF)
"BDNF Val68Met Polymorphism Promotes Compulsive Alcohol Drinking Which is Rescued by TrkB Activation"
|
| 9:20 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | The Reward System |
| 9:00 am - 9:10 am | Discussion Leader: Hitoshi Morikawa (University of Texas at Austin)
"Introduction"
|
| 9:10 am - 9:30 am | Paul Phillips (University of Washington)
"Mesolimbic Dopamine and Reward"
|
| 9:30 am - 9:40 am | Discussion |
| 9:40 am - 10:00 am | Sara Jones (Wake Forest University)
"Presynaptic Mechanisms of Chronic Ethanol-Induced Hypodopaminergia"
|
| 10:00 am - 10:10 am | Discussion |
| 10:10 am - 10:30 am | Coffee Break |
| 10:30 am - 10:50 am | Ross McDevitt (National Institute on Drug Abuse)
"Optogenetic Approaches to Studying Reward and Substance Abuse"
|
| 10:50 am - 11:00 am | Discussion |
| 11:00 am - 11:20 am | Andrew Holmes (National Institute on Alcohol Abuse and Alcoholism)
"Circuit Mechanisms Mediating Rewarded Learning and Addiction-Like Behaviors" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Neil Harrison (Columbia University)
"Neurophysiological Adaptations to Binge Drinking in Adolescent Mice"
|
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:10 pm | Breaking News: Guohong Cui (National Institute on Alcohol Abuse and Alcoholism)
"Probing Brain Reward Circuitry with In Vivo Cell Type-Specific Optical Recordings"
|
| 12:10 pm - 12:15 pm | Discussion |
| 12:15 pm - 12:25 pm | Breaking News: Barbara Juarez (Icahn School of Medicine at Mount Sinai)
"Investigating the Role of Midbrain Dopamine Neurons in Mediating Alcohol Drinking Behaviors"
|
| 12:25 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Translational/Human Studies |
| 7:30 pm - 7:40 pm | Discussion Leader: Ivan Diamond (University of California San Francisco)
"Introduction"
|
| 7:40 pm - 7:50 pm | Breaking News: Natalie Zahr (Stanford University)
"Translational Studies Using In Vivo Neuroimaging: From Rats to Man"
|
| 7:50 pm - 7:55 pm | Discussion |
| 7:55 pm - 8:15 pm | Kathleen Grant (Oregon Health & Science University)
"Phenotypic Characteristics of Drinking to Dependence in Non-Human Primates"
|
| 8:15 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:45 pm | Rajita Sinha (Yale University)
"Alcohol-Related Cortico-Limbic Striatal Adaptations and Alcohol Intake"
|
| 8:45 pm - 8:55 pm | Discussion |
| 8:55 pm - 9:15 pm | Markus Heilig (National Institute on Alcohol Abuse and Alcoholism)
"Medications Development of Alcoholism: Translational Biomarkers"
|
| 9:15 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
