Sunday |
4:00 pm - 8:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Optogenetics and the Next Generation of Circuit Analysis |
| Discussion Leader: David Lovinger (National Institute on Alcohol Abuse and Alcoholism, NIH, USA) |
7:40 pm - 8:00 pm | Introduction by Discussion Leader |
8:00 pm - 9:00 pm | Karl Deisseroth (Stanford University, USA) "Integrated Brainwide Structural and Functional Analysis" |
9:00 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | The Dark Side of
Addiction |
| Discussion Leader: Howard Becker (Medical University of South Carolina, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | George Koob (National Institute on Alcohol Abuse and Alcoholism, NIH, USA) "Neuroplasticity in the Brain Stress Systems in Alcoholism" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:00 am | Jeff Weiner (Wake Forest School of Medicine, USA) "Mesolimbic Adaptations Underlying the Comorbidity Between Anxiety Disorders and Alcoholism" |
10:00 am - 10:10 am | Discussion |
10:10 am - 10:20 am | Selected from Poster Abstracts: Elizabeth Burnett (Medical University of South Carolina, USA) "The Role of the Rostromedial Tegmental Nucleus in Ethanol Withdrawal and Negative Affect" |
10:20 am - 10:25 am | Discussion |
10:25 am - 10:40 am | Olivier George (Scripps Research Institute, USA) "Pharmacogenetic and Optogenetic Control of Alcohol Dependence Through Inactivation of a Withdrawal Neuronal Ensemble in the Central Amygdala" |
10:40 am - 10:45 am | Discussion |
10:45 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Klaus Miczek (Tufts University, USA) "CRF-Dopamine in the VTA Is Critical for Stress-Escalated Alcohol and Stimulant Self-Administration" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:50 am | Yavin Shaham (National Institute on Drug Abuse, Intramural Research Program, NIH, USA) "Context-Induced Relapse to Alcohol Seeking After Punishment-Imposed Abstinence: Behavioral and Neuronal Mechanism" |
11:50 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Gregory Rompala (University of Pittsburgh, USA) "Paternal Chronic Variable Stress Reduces Ethanol Drinking Behavior Selectively in Male Offspring" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Are Ion Channels Key Molecular Substrates of Alcohol? |
| Discussion Leader: C. Fernando Valenzuela (University of New Mexico Health Sciences Center, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:00 pm | Paul Slesinger (Icahn School of Medicine at Mount Sinai, USA) "Molecular Actions of Alcohol on the G Protein-Gated Potassium Channel - So Simple Yet So Complex" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Nigel Atkinson (University of Texas at Austin, USA) "Mechanism of Ethanol Tolerance: Gene Network Analysis in Flies" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Alex Dopico (The University of Tennessee Health Science Center, USA) "Molecular Studies on the Effects of Alcohol on BK Channels" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Selected from Poster Abstracts: Scott Hansen (The Scripps Research Institute, USA) "Lipid-Gated Ion Channels and the Molecular Site of Ethanol Intoxication" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Circuitry of Motivated Behaviors |
| Discussion Leader: John Crabbe (Oregon Health Sciences University, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Antonello Bonci (National Institute on Drug Abuse, NIH, USA) "An Optogenetic-Inspired Rtms Treatment for Cocaine Use Disorders" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Stephan Lammel (University of California, Berkeley, USA) "Identifying Input-Specific Mechanisms Underlying
Reward and Aversion in the Dopamine System" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Kevin Bender (University of California, San Francisco, USA) "D3 Receptor Distribution and Function in Prefrontal Cortex" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Roh-Yu Shen (University at Buffalo, USA) "Developmental Ethanol Exposure Alters How Brain
Reward Pathways Respond to Input Signals" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:45 am | Jun Ding (Stanford University School of Medicine, USA) "The Role of GABA Co-Release by Dopamine Neurons in Enhanced Alcohol Preference" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Sheena Josselyn (Hospital for Sick Children / University of Toronto, Canada) "Manipulating a Rewarding Engram in Mice: Implications for Addiction" |
12:10 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Neuroscience Innovations for Alcohol Research |
| Discussion Leader: Changhai Cui (National Institute on Alcohol Abuse and Alcoholism, NIH, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Bruce Hope (National Institute on Drug Abuse, NIH, USA) "Neuronal Ensembles in Addiction at the Moment" |
7:55 pm - 8:05 pm | Discussion |
8:05 pm - 8:25 pm | Robert Messing (The University of Texas at Austin, USA) "A Crh-Cre Rat for Studying the Anatomy and
Physiology of CRF Neurons" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 8:50 pm | Ian Slaymaker (Broad Institute, USA) "CRISPR-Cas Systems for Genome Editing" |
8:50 pm - 8:55 pm | Discussion |
8:55 pm - 9:10 pm | Catherine Marcinkiewcz (University of North Carolina at Chapel Hill, USA) "Chemogenetic Dissection of Aversive Circuits in the Brain" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:25 pm | Selected from Poster Abstracts: Sophie Laguesse (University of California, San Francisco, USA) "Prosapip1 - A Novel Mediator of Alcohol Abuse Disorder" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Alcohol and Decision Making |
| Discussion Leader: Kathleen Grant (Oregon Health and Science University, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | John Woodward (Medical University of South Carolina, USA) "Orbital Frontal Cortex and Its Role in Alcohol-Induced Behaviors" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Christina Gremel (University of California, San Diego, USA) "Orbitostriatal Gating of Decision Making" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:10 am | Abigail Schindler (University of Washington, USA) "Identification and Pharmacological Reversal of a Selective Perturbation to Mesolimbic Circuitry that Promotes Maladaptive Decision Making After Adolescent Alcohol Use" |
10:10 am - 10:15 am | Discussion |
10:15 am - 10:25 am | Selected from Poster Abstracts: Zoe McElligott (University of North Carolina at Chapel Hill, USA) "Central Amygdala Neurotensin Neurons Regulate Alcohol Consumption, Reward and Sedation" |
10:25 am - 10:30 am | Discussion |
10:30 am - 10:45 am | Coffee Break |
10:45 am - 11:05 am | Rita Goldstein (Mount Sinai School of Medicine, USA) "Role of the mPFC in Extinction, Awareness and
Risk Taking in Cocaine Addiction: MRI Studies" |
11:05 am - 11:15 am | Discussion |
11:15 am - 11:35 am | David Lovinger (National Institute on Alcohol Abuse and Alcoholism, NIH, USA) "Corticostriatal Mechanisms of Alcohol-Promoted
Habitual Behavior" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Jonathan Brigman (The University of New Mexico, USA) "Impact of Developmental Ethanol Exposure on
Neural Circuits Mediating Decision Making" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:15 pm | Selected from Poster Abstracts: Verginia Cuzon Carlson (Oregon Health and Science University, USA) "Gestational Ethanol Exposure During the First Trimester Most Dramatically Decreases GABA Activity in the Dorsolateral Striatum of Mice" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Addiction to Alcohol and Other Substances: Common Neural Substrates |
| Discussion Leader: Lawrence Judson Chandler (Medical University of South Carolina, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:00 pm | John Dani (University of Pennsylvania, USA) "Nicotinic and Stress-Related Mechanisms Boost
Alcohol Self-Administration" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Dorit Ron (University of California, San Francisco, USA) "Corticostriatal BDNF and Alcohol Drinking Behaviors" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Brigitte Kieffer (McGill University, Canada) "Commonalities in Protracted Abstinence to Drugs of Abuse?" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:20 pm | Selected from Poster Abstracts: Vijay Ramchandani (National Institute on Alcohol Abuse and Alcoholism, NIH, USA) "A Human Experimental Model of Stress-Induced Alcohol Self-Administration: Influence of Binge Drinking History" |
9:20 pm - 9:25 pm | Discussion |
9:25 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Drug Development - How Close Are We to a Cure for Alcohol Use Disorders? |
| Discussion Leader: Tamara Phillips (Oregon Health and Science University, USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:30 am | Gunter Schumann (King's College London, United Kingdom) "Developing Imaging Predictors and Neurobehavioral
Phenotypes for Externalizing Disorders" |
9:30 am - 9:40 am | Discussion |
9:40 am - 9:55 am | Jennifer Mitchell (University of California, San Francisco, USA) "The Effects of Intranasal Oxytocin on Social
Perception, Craving and Approach in Alcohol Abusers" |
9:55 am - 10:00 am | Discussion |
10:00 am - 10:20 am | Barbara Mason (The Scripps Research Institute, USA) "Clinical Validation of the Stress Response as a
Pharmacological Target for Treating Alcohol Dependence" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:10 am | Selected from Poster Abstracts: Anushree Karkhanis (Wake Forest School of Medicine, USA) "Social Isolation Stress Mediates Changes in the Kappa Opioid Receptor System Function in the Nucleus Accumbens" |
11:10 am - 11:15 am | Discussion |
11:15 am - 11:35 am | Lorenzo Leggio (National Institute on Alcohol Abuse and Alcoholism / National Institute on Drug Abuse, NIH, USA) "Novel Targets for the Treatment of Alcohol Use
Disorders: A Focus on the Gut-Liver-Brain Axis" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | John Krystal (Yale University School of Medicine, USA) "Developing Pharmacotherapies for Alcoholism
Based on the Interplay of Glutamate and Dopamine Signaling" |
12:05 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Gene-Environment Interplay in Alcohol Actions |
| Discussion Leader: Michael Miles (Virginia Commonwealth University, USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:00 pm | Joel Gelernter (Yale University School of Medicine, USA) "Genetic Influences on Alcohol Dependence Risk
from a Genomewide Perspective - Relationship to Population and Environmental
Factors" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Kim Raab-Graham (University of Texas at Austin, USA) "Does Ethanol Act Like a Rapid Antidepressant?" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Kazue Hashimoto-Torii (Children's National Medical Center, USA) "Single Cell-Epigenetics in Motor Learning
Deficit Elicited by Prenatal Alcohol Exposure" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:15 pm | Jill Bettinger (Virginia Commonwealth University, USA) "A Role for SWI/SNF Chromatin Remodeling in
Alcohol Phenotypes Is Conserved from C. Elegans to Humans" |
9:15 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | Closing Remarks |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |