Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Exploring Neural Mediators of Cue-Triggered Reward Seeking
Discussion Leader: David Lovinger (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
7:40 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 9:00 pm
Patricia Janak (Johns Hopkins University, USA)
"Exploring Neural Mediators of Cue-Triggered Reward Seeking"
9:00 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
The Neural Circuitry of Excessive Alcohol Drinking and Other Maladaptive Behaviors
Discussion Leader: Brian McCool (Wake Forest School of Medicine, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
George Koob (National Institue of Health - National Institute on Alcohol Abuse and Alcoholism, USA)
"Neurobiological Contributions to the Diagnosis, Prevention and Treatment of Alcohol Use Disorders: NIAAA Update"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Wolfgang Sommer (University of Heidelberg, Germany)
"Role of mPFC Neuronal Ensembles in Reward Seeking and Alcohol Addiction"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Selected from Poster Abstracts: Molly McGinnis (Wake Forest School of Medicine, USA)
"Ethanol Withdrawal Produces Opposing Synaptic Alterations of Prelimbic and Infralimbic Terminals in the Rat Basolateral Amygdala"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Sara Jones (Wake Forest School of Medicine, USA)
"Dynorphin/Kappa Opioid Receptor Changes with Immediate and Long-Term Stress/Ethanol Exposure"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Thomas Kash (University of North Carolina at Chapel Hill, USA)
"Alcohol Engages Dynorphin/Kappa Opioid Receptor Signaling in the Extended Amygdala to Alter Behavior"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Selected from Poster Abstracts: William Giardino (Stanford University, USA)
"CRISPR-Cas9 Editing of Hypocretin (Orexin) Receptor Genes in Cell Type-Specific Extended Amygdala Neurons Modulating Alcohol Drinking and Withdrawal-Related Behavior"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Sara Jones (Wake Forest School of Medicine, USA) and Anushree Karkhanis (Wake Forest School of Medicine, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Epigenetic Mechanisms in Alcohol Use Disorder
Discussion Leader: Sean Farris (The University of Texas at Austin, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Gregg Homanics (University of Pittsburgh, USA)
"Gins of Our Fathers: Intergenerational Epigenetic Effects of Alcohol"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Subhash Pandey (University of Illinois at Chicago, USA)
"Neuroepigenetics: The Next Evolution in the Molecular Basis of Alcoholism"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Selected from Poster Abstracts: Daniel Popoola (Research Institute on Addictions, University at Buffalo, USA)
"Maternal and Paternal Lineage Contributions to Transgenerational Effects of Prenatal Alcohol Exposure"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Rita Juanes (Oregon Health and Science University, USA)
"Multi-Tissue DNA Methylation Analysis Implicates Both Pre-Existing Risk and Induced Effects of Chronic Alcohol Use"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alcohol Effects on CNS Development
Discussion Leader: Joanne Weinberg (University of British Columbia, Canada)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Hermes Yeh (Geisel School of Medicine, Dartmouth College, USA)
"Migration Defects and Enduring Behavioral Impairments in a Mouse Model of Prenatal Ethanol Exposure"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Dipak Sarkar (School of Environmental and Biological Sciences, Rutgers University, USA)
"From Germ Cells to Adolescence Brain, Alcohol Programs to Alter the Development of the Neuroendocrine Immune Brain"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Selected from Poster Abstracts: Benjamin Clark (University of New Mexico, USA)
"Altered Spatial Coding by Hippocampal Place Cells Following Moderate Prenatal Alcohol Exposure"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Alexandre Medina (University of Maryland, USA)
"Effect of Developmental Alcohol Exposure on Neuronal Plasticity and Multisensory Integration in the Cortex"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Susan Smith (UNC Nutrition Research Institute, USA)
"Ribosome Dysbiogenesis Is a Novel Apoptotic Effector in Alcohol-Exposed Neural Crest"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Selected from Poster Abstracts: Siara Rouzer (Binghamton University, SUNY, USA)
"The Influence of Age and Moderate Prenatal Ethanol Exposure on CRF1 Receptor Regulation of GABAergic Transmission Within the Central Amygdala in Sprague Dawley Males"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Molecular Gatekeepers of Alcohol Signaling
Discussion Leader: Dorit Ron (University of California, San Francisco, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Markus Heilig (Linkoping University, Sweden)
"A Molecular Mechanism for Choosing Alcohol over a Natural Reward"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Candice Contet (Scripps Research Institute, USA)
"Role of BK Channels in the Behavioral Effects of Alcohol"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Selected from Poster Abstracts: Segev Barak (Tel Aviv University, Israel)
"New Molecular Regulators of Alcohol-Drinking Behaviors"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Patrick Mulholland (Medical University of South Carolina, USA)
"Limiting the Afterhyperpolarization Drives Heavy Alcohol Drinking"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Vulnerability and Resilience to Alcoholism and Comorbid Affective Disorders
Discussion Leader: Klaus Miczek (Tufts University, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Nicholas Gilpin (LSU Health Sciences Center New Orleans, USA)
"Traumatic Stress Reactivity and Neural Mediators of Alcohol Drinking"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Kathleen Grant (Oregon Health and Science University, USA)
"Endocrine, Genomic, and Cognitive Mediation of Vulnerability to Excessive Drinking in Monkeys"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Selected from Poster Abstracts: Jibran Khokhar (University of Guelph, Canada)
"Impaired Brain Reward Circuitry May Underlie Alcohol Drinking in a Rat Model of Schizophrenia and Co-Occurring Alcohol Use Disorder"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Colleen Hanlon (Medical University of South Carolina, USA)
"From Mice to Men: Developing the Medial Prefrontal Cortex as a Translationally-Derived Biomarker for TMS Treatment Development"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Andrew Holmes (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"A Cortical Circuit Regulating Resilience to Compulsive-Like Alcohol-Seeking"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Selected from Poster Abstracts: Anushree Karkhanis (Wake Forest School of Medicine, USA)
"Social Isolation Stress Increases Kappa Opioid Receptor Sensitivity in the Nucleus Accumbens of Rats"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Role of the Cerebellum in Alcohol Use Disorder
Discussion Leader: Changhai Cui (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Martin Paukert (UT Health San Antonio, USA)
"Alcohol and Behavioral State-Dependent Cerebellar Circuit Activity"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Edith Sullivan (Stanford University School of Medicine, USA)
"Two Faces of the Cerebellum in Alcoholism: Site of Damage and Source of Compensation"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:55 pm
Mark Wagner (Stanford University, USA)
"Reward Signaling in Cerebellar Granule Cells"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
David Rossi (Washington State University, USA)
"Genetic Variation in Potentially Rewarding and Aversive Actions of Low [EtOH] in the Cerebellum"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
The Neurocircuitry of Motivated Behaviors
Discussion Leader: Rueben Gonzales (The University of Texas at Austin, USA)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Rainer Spanagel (Central Institute of Mental Health, Germany)
"The Role of Oxytocin in Alcohol Reinforced Behaviors in Rats and Humans"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Veronica Alvarez (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"From Humans to Mice: A Link Between Low Striatal D2 Receptors and the Stimulant and Sedative Effects of Ethanol"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Selected from Poster Abstracts: Kristin Scaplen (Brown University, USA)
"Mapping Neural Circuits Important for Alcohol Reward Memories in Drosophila "
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:15 am
Todd Thiele (University of North Carolina at Chapel Hill, USA)
"The Role of Top-Down and Bottom-Up Neural Circuits in the Modulation of Binge Drinking"
11:15 am - 11:25 am
Discussion
11:25 am - 11:45 am
Paul Phillips (University of Washington, USA)
"Regulation of Motivated Behavior by Phasic Dopamine"
11:45 am - 11:55 am
Discussion
11:55 am - 12:05 pm
Selected from Poster Abstracts: Sara Faccidomo (University of North Carolina at Chapel Hill, USA)
"AMPA Receptor Subunit Activity Within the BLA to AcbC Circuit Is Required for the Positive Reinforcing Effects of Alcohol"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Frontiers: Immune/Microbiome/Inflammasome Interactions in Alcohol Use Disorder
Discussion Leader: Fulton Crews (UNC Bowles Center for Alcohol Studies, USA)
7:30 pm - 7:40 pm
Introduction by Discussion Leader
7:40 pm - 8:00 pm
Adron Harris (The University of Texas at Austin, USA)
"Neuroimmune Regulation of Alcohol Consumption: Which Cells? Which Signals?"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Terrence Deak (Binghamton University, SUNY, USA)
"Paradoxical and Sexually Dimorphic Effects of Adolescent Alcohol Exposure on Neuroimmune Function"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Selected from Poster Abstracts: Mehdi Farokhnia (National Institute on Alcohol Abuse and Alcoholism, NIH, USA)
"Biobehavioral Effects of a Pharmacological Challenge with Exogenous Ghrelin in Alcohol-Dependent Individuals: Is the Ghrelin System a Potential Pharmacological Target for Alcohol Use Disorder?"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:15 pm
Sophie Leclercq (Université Catholique de Louvain, Belgium)
"Implication of the Gut Microbiota in Behavioral Changes Linked to Alcohol Dependence: Mechanistic Approaches and Therapeutic Perspectives"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure