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Alcohol and the Nervous System

Gordon Research Conference

Neurobiology of Alcohol Use Disorder and CNS Comorbidities

October 23 - 28, 2022

Chairs

and

Vice Chairs

and

Residence Inn at Oxnard River Ridge

2101 West Vineyard Ave

Oxnard, California, United States

Venue and Travel Information

Conference Description

Alcohol Use Disorder (AUD) is highly co-morbid with other CNS disorders that include stress and anxiety disorders, pain, CNS injury and other substance use disorders. Alcohol effects on the CNS also differ according to the age and sex of the affected individual, highlighting the need to understand individual variability in AUDs along with their comorbidities. The program for the 2022 meeting of the Alcohol and the Nervous System Gordon Research Conference will include presentations that focus on basic and clinical research investigating the neurobiology of AUD, especially in the context of these prevalent comorbidities and biological vulnerabilities. The Chairs and Vice Chairs will make it a priority to create a meeting program that includes basic and clinical research, and that is diverse by including presenters stratified across career stage, sex/gender, ethnicity, sexual identity and geographical region. The focus on CNS conditions that are co-morbid with AUD will provide a unique opportunity to create new networking and collaborative opportunities for the Alcohol CNS field.

Related Meeting

This GRC will be held in conjunction with the "Alcohol and the Nervous System" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Successes and Challenges in Translational Alcohol Research Discussion Leader:
7:40 pm - 8:25 pm	"The Negative Emotional Side of Alcohol Use Disorder: Implications for Deaths of Despair and the COVID-19 Pandemic"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 9:20 pm	"Successes and Challenges in Translational Research with Alcohol"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Alcohol Interactions with Stress and Brain Stress Systems Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"The Intersection of Trauma, PTSD, and Addiction"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Alcohol Interactions with Adolescent Psychosocial Stress and Mesolimbic Stress Systems"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Lateral Hypothalamus Circuits Mediate Stress-Induced Alterations in Alcohol-Related Behaviors in Rats"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	"Dorsal Medial Prefrontal Cortex Neural Firing Correlates of Compulsive Drinking in Alcohol Preferring P Rats"
11:10 am - 11:15 am	Discussion
11:15 am - 11:35 am	"Regulation of Stress-Alcohol Interactions: A Role for Cortical CRF."
11:35 am - 11:45 am	Discussion
11:45 am - 12:05 pm	"Prenatal Alcohol Rewires Anxiety Circuits Across Development"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Stress Reactivity and Alcohol Drinking: Corticolimbic Activity and Role of Endocannabinoids in Modulating Stress Reactive Behaviors"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Mechanisms and Pathways Underlying Excessive Alcohol Drinking Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Neurobiological Mechanisms of Individual Vulnerability to Alcohol Addiction-like Behaviors"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"Distinct Circuits Promoting and Impeding Alcohol Drinking in Drosophila"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Hypodopaminergic State of the Nigrostriatal Pathway Participates in Compulsive Alcohol Use"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Neural Substrates of Binge Drinking"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Executive Control and Flexibility in Alcohol Actions Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Alcohol Misuse, Behavioral Flexibility, and Excitatory/Inhibitory Balance in Control Circuitry"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Chronic Alcohol Exposure Disrupts Behavioral Flexibility via Hyperactive Premotor Corticostriatal Activity"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Vulnerability of Corticothalamic Function in Rodent Models of ADHD and Adolescent Alcohol Abuse"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Reversal Learning Deficits Following Chronic Alcohol: Does this Translate to a Change in Relapse Propensity?"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Prefrontal Cortical Modulation of Pupil-Linked Arousal and Binge-Like Drinking"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	"Impact of Alcohol and Stress on Frontal Cortical Networks Underlying Cognitive Control"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Investigating Cortical Astrocyte Calcium Relationships with Arousal Shifts During Voluntary Alcohol Consumption"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	New Tools for Biomedical Alcohol Research Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Cell-Type and Spatially Resolved Molecular Signatures Across Reward Circuits in the Human Brain"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	"Neural Ensembles of Social Stress-Escalated Alcohol Consumption"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	"Targeting Astrocytes in the Regulation of Reward Seeking"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Next Generation Approaches for Investigating Neuropeptidergic Circuits in Reward and Motivation"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	"Gene-editing Approaches to Understand Neuronal and Circuit Function in Behavior"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Alcohol Interactions with Pain Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Chronic Pain and Alcohol Use: Future Directions for Treatment"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Intersecting Mechanisms and Treatment Opportunities for Pain and Alcohol Use Disorder"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Pain Recruitment of the Dynorphinergic System in the Nucleus Accumbens Impacts Negative Affect and Alcohol Relapse-like Behavior in Rodents"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Amygdala Circuits for Bidirectional Control of Pain"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"Adolescent Alcohol Exposure Produces Sex-Dependent Long-Term Changes in Hyperalgesia and Amygdala Circuitry"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	"Alcohol Dysregulation of Midbrain Extended Amygdala Circuitry in Mice"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Preclinical Assessment of the Effects of Cannabidiol in Rat Models of Alcohol Use Disorder"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Co-Morbid Use of Alcohol and Other Drugs Discussion Leader:
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	"Interactions between Alcohol and Other Drugs Across Development"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"Patterns and Consequences of Cocaine-Alcohol Polysubstance Use in Humans and Rodents"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	"Adolescent Intermittent Ethanol Exposure Induces Sex-specific and Time-dependent Changes in Affective Behaviors and Metabolomic Profiles"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Alcohol and Other Substance Co-Use in Clinical Samples"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Motivational and Learned Determinants of Alcohol Self-Administration Discussion Leader:
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	"Basal Ganglia Roles in Alcohol Drinking and Impairment of Decision Making"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	"Alcohol Impacts Neural Encoding and Molecular Mechanisms of Motivation"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Ovarian Hormone Influences on Aversion-resistant Intake in Female C57BL/6J Mice"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Estrogen Modulation of Limbic Synapses and Alcohol Drinking"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	"The Role of Anterior Insular Cortex Inputs to Dorsolateral Striatum in Binge Alcohol Drinking"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	"Cellular and Molecular Mechanisms of Alcohol-Memory Reconsolidation and Relapse"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	"Adolescent Alcohol Exposure Impairs Response Inhibition and Alters Orbitofrontal Cortex-Striatal Dynamics in Adult and Adolescent Rats"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Alcohol Use Disorder Research: Co-Morbidities and Inequities Discussion Leader:
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:25 pm	"Exploring an Insula-BNST Circuit in Mouse and Human: The Struggle is Real"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:40 pm	Introduction by Discussion Leader
8:40 pm - 9:10 pm	"Cannabis and Alcohol Use Comorbidity in Animal Models"
9:10 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	Closing Remarks
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institute On Alcohol Abuse And Alcoholism of the National Institutes of Health under Award Number R13AA028160. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Alcohol and the Nervous System (GRS)

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