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Alcohol and the Nervous System

Gordon Research Conference

Neurobiology of Alcohol Use Disorder and CNS Comorbidities

October 23 - 28, 2022

Chairs Nicholas W. Gilpin and Patricia H. Janak

Vice Chairs Rajita Sinha and Joyce Besheer

Residence Inn at Oxnard River Ridge

2101 West Vineyard Ave

Oxnard, California, United States

Venue and Travel Information

Conference Description

Alcohol Use Disorder (AUD) is highly co-morbid with other CNS disorders that include stress and anxiety disorders, pain, CNS injury and other substance use disorders. Alcohol effects on the CNS also differ according to the age and sex of the affected individual, highlighting the need to understand individual variability in AUDs along with their comorbidities. The program for the 2022 meeting of the Alcohol and the Nervous System Gordon Research Conference will include presentations that focus on basic and clinical research investigating the neurobiology of AUD, especially in the context of these prevalent comorbidities and biological vulnerabilities. The Chairs and Vice Chairs will make it a priority to create a meeting program that includes basic and clinical research, and that is diverse by including presenters stratified across career stage, sex/gender, ethnicity, sexual identity and geographical region. The focus on CNS conditions that are co-morbid with AUD will provide a unique opportunity to create new networking and collaborative opportunities for the Alcohol CNS field.

Related Meeting

This GRC will be held in conjunction with the "Alcohol and the Nervous System" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Successes and Challenges in Translational Alcohol Research Discussion Leader: Rajita Sinha (Yale Stress Center, United States)
7:40 pm - 8:25 pm	George Koob (National Institute on Alcohol Abuse and Alcoholism, NIH, United States) "The Negative Emotional Side of Alcohol Use Disorder: Implications for Deaths of Despair and the COVID-19 Pandemic"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 9:20 pm	Harriet de Wit (University of Chicago, United States) "Successes and Challenges in Translational Research with Alcohol"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Alcohol Interactions with Stress and Brain Stress Systems Discussion Leader: Jamie Maguire (Tufts University School of Medicine, United States)
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	Kerry Ressler (Harvard Medical School, United States) "The Intersection of Trauma, PTSD, and Addiction"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	Anushree Karkhanis (Binghamton University - SUNY, United States) "Alcohol Interactions with Adolescent Psychosocial Stress and Mesolimbic Stress Systems"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	Marcus Weera (LSU Health New Orleans, United States) "Lateral Hypothalamus Circuits Mediate Stress-Induced Alterations in Alcohol-Related Behaviors in Rats"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	Nicholas Timme (Indiana University - Purdue University Indianapolis, United States) "Dorsal Medial Prefrontal Cortex Neural Firing Correlates of Compulsive Drinking in Alcohol Preferring P Rats"
11:10 am - 11:15 am	Discussion
11:15 am - 11:35 am	Jennifer Rinker (Medical University of South Carolina, United States) "Regulation of Stress-Alcohol Interactions: A Role for Cortical CRF."
11:35 am - 11:45 am	Discussion
11:45 am - 12:05 pm	Marvin Diaz (Binghamton University, United States) "Prenatal Alcohol Rewires Anxiety Circuits Across Development"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Laura Ornelas (University of North Carolina at Chapel Hill, United States) "Stress Reactivity and Alcohol Drinking: Corticolimbic Activity and Role of Endocannabinoids in Modulating Stress Reactive Behaviors"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: Jocelyn Richard (University of Minnesota, United States) and James Jentsch (Binghamton University, United States)
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Mechanisms and Pathways Underlying Excessive Alcohol Drinking Discussion Leader: Karla Kaun (Brown University, United States)
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	Markus Heilig (Linkoping University, Sweden) "Neurobiological Mechanisms of Individual Vulnerability to Alcohol Addiction-like Behaviors"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	Adrian Rothenfluh (University of Utah, United States) "Distinct Circuits Promoting and Impeding Alcohol Drinking in Drosophila"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Sebastien Carnicella (Inserm, France) "Hypodopaminergic State of the Nigrostriatal Pathway Participates in Compulsive Alcohol Use"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Angela Ozburn (Oregon Health and Science University, United States) "Neural Substrates of Binge Drinking"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Executive Control and Flexibility in Alcohol Actions Discussion Leader: Cody Siciliano (Vanderbilt University School of Medicine, United States)
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	Charlotte Boettiger (University of North Carolina at Chapel Hill, United States) "Alcohol Misuse, Behavioral Flexibility, and Excitatory/Inhibitory Balance in Control Circuitry"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	Christina Gremel (University of California, San Diego, United States) "Chronic Alcohol Exposure Disrupts Behavioral Flexibility via Hyperactive Premotor Corticostriatal Activity"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	Michael Salling (Louisiana State University Health Sciences Center, United States) "Vulnerability of Corticothalamic Function in Rodent Models of ADHD and Adolescent Alcohol Abuse"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Christina Perry (Florey Institute of Neuroscience and Mental Health, Australia) "Reversal Learning Deficits Following Chronic Alcohol: Does this Translate to a Change in Relapse Propensity?"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Rafiq Huda (Rutgers University, United States) "Prefrontal Cortical Modulation of Pupil-Linked Arousal and Binge-Like Drinking"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	David Moorman (University of Massachusetts Amherst, United States) "Impact of Alcohol and Stress on Frontal Cortical Networks Underlying Cognitive Control"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Grayson Sipe (Massachusetts Institute of Technology, United States) "Investigating Cortical Astrocyte Calcium Relationships with Arousal Shifts During Voluntary Alcohol Consumption"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	New Tools for Biomedical Alcohol Research Discussion Leader: Karen Szumlinski (University of California, Santa Barbara, United States)
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	Keri Martinowich (Lieber Institute for Brain Development, United States) "Cell-Type and Spatially Resolved Molecular Signatures Across Reward Circuits in the Human Brain"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:30 pm	Rajani Maiya (Louisiana State University Health Sciences Center-New Orleans, United States) "Neural Ensembles of Social Stress-Escalated Alcohol Consumption"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:55 pm	Jacqueline Barker (Drexel University College of Medicine, United States) "Targeting Astrocytes in the Regulation of Reward Seeking"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	Daniel Castro (Washington University in St. Louis, United States) "Next Generation Approaches for Investigating Neuropeptidergic Circuits in Reward and Motivation"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:25 pm	Barbara Juarez (University of Washington; University of Maryland-Baltimore, United States) "Gene-editing Approaches to Understand Neuronal and Circuit Function in Behavior"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Alcohol Interactions with Pain Discussion Leader: Imad Damaj (Virginia Commonwealth University, United States)
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	Katie Witkiewitz (University of New Mexico, United States) "Chronic Pain and Alcohol Use: Future Directions for Treatment"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	Scott Edwards (LSU Health Sciences Center, United States) "Intersecting Mechanisms and Treatment Opportunities for Pain and Alcohol Use Disorder"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	Lucía Hipólito (University of Valencia, Spain) "Pain Recruitment of the Dynorphinergic System in the Nucleus Accumbens Impacts Negative Affect and Alcohol Relapse-like Behavior in Rodents"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Yarimar Carrasquillo (National Institutes of Health, United States) "Amygdala Circuits for Bidirectional Control of Pain"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	Tiffany Wills (LSU Health Sciences Center New Orleans, United States) "Adolescent Alcohol Exposure Produces Sex-Dependent Long-Term Changes in Hyperalgesia and Amygdala Circuitry"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	Thomas Kash (University of North Carolina at Chapel Hill, United States) "Alcohol Dysregulation of Midbrain Extended Amygdala Circuitry in Mice"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Giordano de Guglielmo (University of California, San Diego, United States) "Preclinical Assessment of the Effects of Cannabidiol in Rat Models of Alcohol Use Disorder"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Co-Morbid Use of Alcohol and Other Drugs Discussion Leader: Leandro Vendruscolo (National Institute on Drug Abuse, United States)
7:30 pm - 7:45 pm	Introduction by Discussion Leader
7:45 pm - 8:05 pm	Jibran Khokhar (University of Western Ontario, Canada) "Interactions between Alcohol and Other Drugs Across Development"
8:05 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	Lori Knackstedt (University of Florida, United States) "Patterns and Consequences of Cocaine-Alcohol Polysubstance Use in Humans and Rodents"
8:35 pm - 8:45 pm	Discussion
8:45 pm - 8:55 pm	Antoniette Maldonado-Devincci (North Carolina A&T State University, United States) "Adolescent Intermittent Ethanol Exposure Induces Sex-specific and Time-dependent Changes in Affective Behaviors and Metabolomic Profiles"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	Lara Ray (UCLA, United States) "Alcohol and Other Substance Co-Use in Clinical Samples"
9:20 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Motivational and Learned Determinants of Alcohol Self-Administration Discussion Leader: Dorit Ron (University of California, San Francisco, United States)
9:00 am - 9:15 am	Introduction by Discussion Leader
9:15 am - 9:35 am	David Lovinger (National Institute on Alcohol Abuse and Alcoholism, NIH, United States) "Basal Ganglia Roles in Alcohol Drinking and Impairment of Decision Making"
9:35 am - 9:45 am	Discussion
9:45 am - 10:05 am	Jocelyn Richard (University of Minnesota, United States) "Alcohol Impacts Neural Encoding and Molecular Mechanisms of Motivation"
10:05 am - 10:15 am	Discussion
10:15 am - 10:25 am	Elizabeth Sneddon-Yepez (Miami University, United States) "Ovarian Hormone Influences on Aversion-resistant Intake in Female C57BL/6J Mice"
10:25 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	Kristen Pleil (Weill Cornell Medicine, Cornell University, United States) "Estrogen Modulation of Limbic Synapses and Alcohol Drinking"
11:20 am - 11:30 am	Discussion
11:30 am - 11:40 am	David Haggerty (Indiana University School of Medicine, United States) "The Role of Anterior Insular Cortex Inputs to Dorsolateral Striatum in Binge Alcohol Drinking"
11:40 am - 11:45 am	Discussion
11:45 am - 12:05 pm	Segev Barak (Tel Aviv University, Israel) "Cellular and Molecular Mechanisms of Alcohol-Memory Reconsolidation and Relapse"
12:05 pm - 12:15 pm	Discussion
12:15 pm - 12:25 pm	Aqilah McCane (Oregon Health and Science University, United States) "Adolescent Alcohol Exposure Impairs Response Inhibition and Alters Orbitofrontal Cortex-Striatal Dynamics in Adult and Adolescent Rats"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Alcohol Use Disorder Research: Co-Morbidities and Inequities Discussion Leader: Heather Richardson (University of Massachusetts Amherst, United States)
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 8:25 pm	Danny Winder (Vanderbilt University School of Medicine, United States) "Exploring an Insula-BNST Circuit in Mouse and Human: The Struggle is Real"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 8:40 pm	Introduction by Discussion Leader
8:40 pm - 9:10 pm	Michael Taffe (University of California, San Diego, United States) "Cannabis and Alcohol Use Comorbidity in Animal Models"
9:10 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	Closing Remarks
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institute On Alcohol Abuse And Alcoholism of the National Institutes of Health under Award Number R13AA028160. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Alcohol and the Nervous System (GRS)

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