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Alcohol and the Nervous System

Gordon Research Conference

Translational Neuroscience of Alcohol: Integration of Basic and Clinical Research

February 11 - 16, 2024

Chairs

and

Vice Chairs

and

Grand Galvez

2024 Seawall Boulevard

Galveston, Texas, United States

Venue and Travel Information

Conference Description

The Alcohol and the Nervous System GRC is a premier, international scientific conference focused on advancing the frontiers of science through the presentation of cutting-edge and unpublished research, prioritizing time for discussion after each talk and fostering informal interactions among scientists of all career stages. The conference program includes a diverse range of speakers and discussion leaders from institutions and organizations worldwide, concentrating on the latest developments in the field. The conference is five days long and held in a remote location to increase the sense of camaraderie and create scientific communities, with lasting collaborations and friendships. In addition to premier talks, the conference has designated time for poster sessions from individuals of all career stages, and afternoon free time and communal meals allow for informal networking opportunities with leaders in the field.

Related Meeting

This GRC will be held in conjunction with the "Alcohol and the Nervous System" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
2:00 pm - 9:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm	Keynote Session: Integration of Basic and Clinical Research in Translational Neuroscience Discussion Leaders: and
7:40 pm - 7:55 pm	Introduction by Discussion Leader
7:55 pm - 8:25 pm	"The Alcohol Use Disorder 3 Stage Cycle, 3 Domain, 3 Neurocircuit Framework: A Catalyst for Translational Research"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 9:05 pm	"Cholinergic Mechanisms of Alcohol Reinforcement"
9:05 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Monday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Alcohol Neuroplasticity, Stress Sensitivity, and Motivation Discussion Leader:
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:35 am	"Toward the Development of a Rodent Model of Salience Misattribution, a Clinically Important Phenotype of Alcohol Use Disorder"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	"Trigeminal Circuits for Detection of Chemical Threats Dictate Ethanol Preference"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	"Real-World Approaches for Examining Alcohol-Related Changes in Stress Physiology"
10:15 am - 10:20 am	Discussion
10:20 am - 10:30 am	"Sex Effects on Neural Activation During Alcohol Abstinence"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:30 am	"Put a Kap on It: Differential Effects of the Kappa Opioid Receptor in the Nucleus Accumbens on Ethanol Drinking and Affective Behavior"
11:30 am - 11:35 am	Discussion
11:35 am - 11:50 am	"Glial Modulators of Alcohol and Stress at mPFC Synapses"
11:50 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Neurobiological Mechanisms of Stress and Cue Reactivity in Pain With and Without Alcohol Use Disorder"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring. Organizers: and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Consequences of Alcohol Exposure During Development Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"How Does Alcohol Use Influence Adolescent Neurodevelopment?"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Prenatal Alcohol Exposure: Health Outcomes and Resiliency Across the Lifespan"
8:20 pm - 8:25 pm	Discussion
8:25 pm - 8:40 pm	"Genetic Factors Underlying Susceptibility to Prenatal Alcohol Exposure"
8:40 pm - 8:45 pm	Discussion
8:45 pm - 9:00 pm	"Translational Integration of Preclinical and Clinical Neuroscience Research: Understanding Adolescence and the Impacts of Alcohol"
9:00 pm - 9:05 pm	Discussion
9:05 pm - 9:15 pm	"Sex Differences in Drinking and Alcohol-Induced Transcriptional Changes Associated with Gonadal and Chromosomal Sex"
9:15 pm - 9:20 pm	Discussion
9:20 pm - 9:30 pm	General Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Novel Molecules and Therapeutics for Alcohol Use Disorder Discussion Leader:
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Cholinergic Dysregulation as a Treatment Target for Alcohol Use Disorder"
9:25 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Interventions for Fetal Alcohol Spectrum Disorders"
9:50 am - 9:55 am	Discussion
9:55 am - 10:10 am	"Modulating Prefrontal Cortex Inhibitory Circuits to Attenuate Drinking and Associated Affective Behaviors"
10:10 am - 10:15 am	Discussion
10:15 am - 10:30 am	"Inhibition of Adenosine Receptors as a New Target to Develop Medication for Alcohol Use Disorder"
10:30 am - 10:35 am	Discussion
10:35 am - 11:05 am	Coffee Break
11:05 am - 11:25 am	"Alcohol and Brain Glycolysis: A Journey Full of Surprises"
11:25 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Endocannabinoid Modulation of Alcohol Withdrawal-Associated Hyperalgesia in Mice"
11:50 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Pregnenolone Effects on Alcohol Craving, Stress Biology and Clinical Outcomes"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Alcohol, Neuroimmune and Immune Interactions Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"Targeting Neuroimmune Mechanisms in Alcohol Use Disorder"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:15 pm	"Microglia and Interferon Promote Alcohol-Induced Hyperkateifia"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:35 pm	"Neuroimmune Modulation as a Treatment Target for Alcohol use Disorder: Clinical Studies of Ibudilast"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 8:50 pm	"Alcohol Exacerbation of Neuroinflammation Post-Repeated Mild TBI in Adolescence"
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:05 pm	"The Role of Astrocyte-Neuronal Crosstalk in Ethanol-Induced Behavioral Dysfunction"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:30 pm	General Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Cellular, Molecular and System Level Effects of Alcohol Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Neuroimmune Transcriptional Mechanisms in Alcohol Use Disorder"
9:25 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Alcohol Modulation of Striatal Inhibition"
9:50 am - 9:55 am	Discussion
9:55 am - 10:10 am	"Blood Marker Correlates of Brain MRI Signal Intensities"
10:10 am - 10:15 am	Discussion
10:15 am - 10:25 am	"Regulation of Alcohol Action in the Brain by a GABA_A Receptor Auxiliary Subunit"
10:25 am - 10:30 am	Discussion
10:30 am - 11:05 am	Coffee Break
11:05 am - 11:25 am	"Alcohol-Induced Microglia Dysfunction: Snapshots Along the Lifespan"
11:25 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Manipulating the Neurotensin System: Alcohol and Motivated Behaviors"
11:50 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"The Transcriptomic Landscape of Compulsive-Like Alcohol Drinking"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Alcohol and Gut-Brain Interactions Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:55 pm	"The Role of Glucagon-Like Peptide 1 (GLP-1) in Alcohol Use Disorders: Preclinical and Clinical Evidence"
7:55 pm - 8:00 pm	Discussion
8:00 pm - 8:15 pm	"Gut-Brain Neuropeptides as Treatment Targets for Alcohol Use Disorder"
8:15 pm - 8:20 pm	Discussion
8:20 pm - 8:35 pm	"Decoding Alcohol's Effects on Gut-Brain Dynamics: Insights From Metabolic Surgeries"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 8:55 pm	"Integration of Central and Peripheral Signaling Systems in Alcohol Intake Models"
8:55 pm - 9:00 pm	Discussion
9:00 pm - 9:10 pm	"Coordinated Action of a Gut-Liver Pathway Drives Alcohol Detoxification and Consumption"
9:10 pm - 9:15 pm	Discussion
9:15 pm - 9:30 pm	General Discussion
Thursday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Business Meeting Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm	Alcohol Neurobehavioral Adaptations and Cognitive and Affective Effects Discussion Leaders: and
9:00 am - 9:05 am	Introduction by Discussion Leader
9:05 am - 9:25 am	"Chronic Alcohol and Stress Produce Deficits in Behavioral Flexibility"
9:25 am - 9:30 am	Discussion
9:30 am - 9:45 am	"Ultrasonic Drug Uncaging for Targeted Neuro-Pharmacology: Applications for Substance Abuse"
9:45 am - 9:50 am	Discussion
9:50 am - 10:05 am	"Dissecting Neuronal Pathways Driving Negative Affective Disturbances in Alcohol Abstinence"
10:05 am - 10:10 am	Discussion
10:10 am - 10:20 am	"TARP y-8 is a Novel, Activity-Dependent Regulator of Alcohol Self-Administration"
10:20 am - 10:25 am	Discussion
10:25 am - 10:55 am	Coffee Break
10:55 am - 11:15 am	"Neurofunctional Domains Mapping the 3Rs of Alcohol's Effects: Reward, Relief and Regulation"
11:15 am - 11:20 am	Discussion
11:20 am - 11:35 am	"The Neuroscience of Neuropeptides: What is Somatostatin Doing in the Prefrontal Cortex?"
11:35 am - 11:40 am	Discussion
11:40 am - 11:50 am	"Memory Biases Associated with Harmful Drinking Behavior in Humans"
11:50 am - 11:55 am	Discussion
11:55 am - 12:05 pm	"Follow Your Heart: Sex Differences in Heart Rate Variability Measures that Predict Alcohol Drinking"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:30 pm	General Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Alcohol Genetics, Epigenetics and Individual Differences Discussion Leaders: and
7:30 pm - 7:35 pm	Introduction by Discussion Leader
7:35 pm - 7:50 pm	"Translational Studies in Adolescent Alcohol Exposure: Sleep, Suicide and Genetic/Epigenetic Findings"
7:50 pm - 7:55 pm	Discussion
7:55 pm - 8:10 pm	"Alcohol Use and Use Disorders: Insights from Genomewide Association Studies"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:30 pm	"Neuroepigenetics of Alcohol Use Disorder: Mechanisms, Phenotypes, and Treatment"
8:30 pm - 8:35 pm	Discussion
8:35 pm - 8:50 pm	"Chronic Alcohol Perturbs the "Astro-Some""
8:50 pm - 8:55 pm	Discussion
8:55 pm - 9:05 pm	"Studying the Transcriptome for Alcohol Use Disorder"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	General Discussion
9:25 pm - 9:30 pm	Closing Remarks
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institutes of Health under Award Number 1R13AA031419-01 . The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Alcohol and the Nervous System (GRS)

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