Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Keynote Lectures
Discussion Leader: Hidekazu Tsukamoto (University of Southern California, United States)
7:40 pm - 7:50 pm
Opening Remarks
7:50 pm - 8:25 pm
Tatiana Kisseleva (University of California San Diego, United States)
"Th17 at the Intersection of Alcohol Use Disorder and Organ Damage"
8:25 pm - 8:40 pm
Discussion
8:40 pm - 9:15 pm
Zhao Zhang (University of Texas Southwestern Medical Center, United States)
"Forward Genetics of Fatty Liver Disease"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Alcohol and the Metabolic Syndrome
Discussion Leader: Harmeet Malhi (Mayo Clinic, United States)
9:00 am - 9:20 am
Mrigya Babuta (Beth Israel Deaconess Medical Center and Harvard Medical School, United States)
"Combined Liver Insult of Alcoholic and Non-Alcoholic Liver Disease: Lessons from a Preclinical Model"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Laura Nagy (Liver Disease Research Center, Cleveland Clinic Lerner Research Institute, United States)
"Differences in the Role of RIP3 and MLKL in Alcohol-Associated and Non-Alcohol Associated Liver Disease"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Anna Mae Diehl (Duke University Medical Center, United States)
"Metabolic Reprogramming and Liver Repair"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Z. Gordon Jiang (Beth Israel Deaconess Medical Center and Harvard Medical School, United States)
"Altered Lipoprotein Metabolism in Alcoholic Hepatitis: Egg or Chicken?"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Bryan Mackowiak (National Institute on Alcohol Abuse and Alcoholism (NIH), United States)
"CYP2B10 is Induced by Binge Ethanol and Protects against Ethanol-Induced Liver Injury"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Devanshi Seth (Centenary Institute, Royal Prince Alfred Hospital, Australia)
"Clinical Relevance of Underlying Genetics in Patients with High Alcohol Use and Cirrhosis: the GenomALC Study"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Irina Kirpich (University of Louisville, United States)
"Bioactive Lipid Metabolites: Novel Therapeutic Targets and Potential Treatment Strategies in Alcohol-Associated Liver Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Mark McNiven (Mayo Clinic, United States)
"Ethanol-Induced Stress in Hepatocytes Attenuates Lipophagy of Nascent Lipid Droplets at the Endoplasmic Reticulum Surface"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Elizabeth Kovacs (University of Colorado Denver, United States) and Samantha Yeligar (Emory University / Atlanta VA Health Care System, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Alcohol and Lifespan
Discussion Leader: Patricia Molina (LSU Health Sciences Center New Orleans, United States)
7:30 pm - 7:50 pm
Rachel McMahan (University of Colorado Anschutz Medical Campus, United States)
"Age-Related Dysregulation of the Bile Acid-Gut Microbiome Axis in Response to Ethanol"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Wen-Xing Ding (University of Kansas Medical Center, United States)
"Acceleration of Alcoholic Tissue Damage during Aging: Role of Autophagy"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Paige Anton (University of Colorado Anschutz, United States)
"Exploring Microglia Autophagic Flux Impairments as a Driver of Advanced Age and Ethanol Induced Neuroinflammation"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Chueh-Lung Hwang (University of Texas at Arlington, United States)
"Vascular Effects of Binge Drinking in Mid-life Adults"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Mengwei Zang (University of Texas Health Science Center at San Antonio, United States)
"Age-Dependent Induction of the NADase CD38 is Implicated in the Progressive Alcohol-Associated Liver Disease during Aging"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Kusum Kharbanda (VA Medical Center, United States)
"Deletion of Phosphatidylethanolamine Methyltransferase Disrupts One-Carbon Metabolism to Promote Alcohol-Induced and Age-Dependent Progression of Liver Injury"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Microbiome and Intestine-Derived Molecules
Discussion Leader: Craig McClain (University of Louisville, United States)
9:00 am - 9:20 am
Wenke Feng (University of Louisville, United States)
"Intestinal Targets of Probiotic-Derived Extracellular Vesicles in Alcohol-Associated Liver Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Cristina Llorente (University of California, San Diego, United States)
"Goblet Cells and Goblet Cell-Associated Passages as Modulators of Intestinal Immunity"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Je-Hyun Yoon (Medical University of South Carolina, United States)
"Intestinal Exosomes in Alcohol-Induced Liver Injury"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Holger Willenbring (UCSF, United States)
"Cell-Based Therapy for Alcohol-Associated Liver Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Grayson Way (Virginia Commonwealth University, United States)
"The Role of Sphingosine Kinase 2 and Gut-liver-Axis in Alcohol-Induced live injury"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Wiramon Rungratanawanich (National Institute on Alcohol Abuse and Alcoholism (NIAAA), United States)
"Increased Gut Leakiness, Endotoxemia, and Acute Liver Injury in ALDH2-KO Mice after a Single Dose of Binge Alcohol through the Gut-Liver Axis"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Suling Zeng (univerity of california, United States)
"Candida Albicans-Apecific Th17 Cell-Mediated Response Contributes to Alcohol- Associated Liver Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Tim Hendrikx (Medical University Vienna, Austria)
"Regulation of Intestinal IgA by Functional Hepatic pIgR is Required to Reduce Bacterial Overgrowth and Limit Ethanol-Induced Liver Disease in Mice."
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Immunity and Infections: Implications for Diseases Associated with Alcohol
Discussion Leader: Pranoti Mandrekar (University of Massachusetts Medical School, United States)
7:30 pm - 7:50 pm
Ellen Burnham (University of Colorado Anschutz Medical Campus, United States)
"Alcohol, Lung Injury and COVID-19"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Derrick Samuelson (University of Nebraska Medical Center, United States)
"Alcohol-Related Lung Infection via Gut-Lung Axis"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Rebecca McCullough (University of Colorado Anschutz Medical Campus, United States)
"The 'Ins' and 'Outs' of Anaphylatoxins in Alcohol-Associated Liver Disease"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Quanri Zhang (Cleveland Clinic Lerner Research Institute, United States)
"Mincle-GSDMD Mediated Release of IL-1ß/IL-18 Containing sEVs Contributes to Ethanol-Induced Liver Injury"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Matthew McConnell (Yale University, United States)
"Platelets Upregulate S100A8, a Mediator of Endothelial Dysfunction and Inflammation, in Alcohol-Associated Hepatitis"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Alcohol-Mediated Changes in Organ Metabolism
Discussion Leader: Laura Nagy (Liver Disease Research Center, Cleveland Clinic Lerner Research Institute, United States)
9:00 am - 9:20 am
Bin Gao (National Institutes of Health, United States)
"New Insight into Alcohol Metabolism, Organ Damage and Cancer"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Steve Kliewer (University of Texas Southwestern Medical Center, United States)
"Protective Effects of FGF21 Against Alcohol"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Srinivasan Dasarathy (Cleveland Clinic, United States)
"Skeletal Muscle in Alcohol-related Liver Disease- Organelle and Metabolic Responses"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Mack Mitchell (University of Texas Southwestern Medical Center, United States)
"Alcohol and Clinical Effects on the Metabolic Syndrome"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Janos Paloczi (National Institutes of Health, National Institute on Alcohol Abuse and Alcoholism, United States)
"Combined Synthetic Cannabinoids and Alcohol Intoxication Induces Detrimental Cardiac Consequences: Role of CB1-R Signaling."
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Manikandan Panchatcharam (LSU Health Sciences Center Shreveport, United States)
"Alcohol-Induced Oxidative Stress in Myocardium"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Flavia Souza-Smith (LSU Health Sciences Center New Orleans, United States)
"Role of Lymph from Alcohol-Treated Animals on Naïve Perilymphatic Adipose Tissue Immunomodulation"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Pierre-Jacques Brun (Columbia University, United States)
"Retinoid Stores Attenuate Deleterious Effects of Alcohol on Pancreas"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Cancer Stem Cells and Alcohol-Associated Cancer
Discussion Leader: Andras Orosz (National Institute on Alcohol Abuse and Alcoholism, NIH, United States)
7:40 pm - 8:00 pm
Yin Cao (Washington University in St. Louis, United States)
"Alcohol and Colorectal Cancer: an Epidemiologic Perspective"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Faraz Bishehsari (Rush University Medical Center, United States)
"Alcohol and Colon Cancer: The “Clock” is Ticking"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Keigo Machida (University of Southern California, United States)
"Metabolic Reprogramming of Liver Tumor Initiating Cells"
9:00 pm - 9:10 pm
Discussion
9:10 pm - 9:20 pm
Liya Pi (Tulane University, United States)
"Hepatocellular Carcinoma in NAFLD and ALD Occur via Distinct Stemness Activation And Metabolic Reprogramming in Diabetic Mice"
9:20 pm - 9:25 pm
Discussion
9:25 pm - 9:35 pm
Benita McVicker (University of Nebraska Medical Center, United States)
"Alcohol-Sensitized Macrophages Promote Colorectal Liver Metastasis"
9:35 pm - 9:40 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Discovery of Mechanism-Based Biomarkers
Discussion Leaders: Li Lin (National Institute on Alcohol Abuse and Alcoholism, NIH, United States)
9:00 am - 9:20 am
Gavin Arteel (University of Pittsburgh, United States)
"The Degradome as Biomarkers and (Potentially) Mediators of Alcohol Organ Damage"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Harmeet Malhi (Mayo Clinic, United States)
"Extracellular Vesicle Signature Induced by Alcohol"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Steven Weinman (University of Kansas Medical Center, United States)
"Single Cell RNA Sequencing insights into the role of Kupffer cell subsets in progression of Alcohol-Associated Liver Disease"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Suthat Liangpunsakul (Indiana University School of Medicine, United States)
"Non-Coding RNAs and Survival Outcomes in Patients with Alcohol-Associated Liver Disease"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Brianna Bourgeois (LSUHSC New Orleans, United States)
"Differential Expression of miRNA Cargo in Extracellular Vesicles Released from Adipocytes and Myotubes of Chronic Binge Alcohol-Administered SIV-infected Male Macaques"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Marko Mrdjen (Cleveland Clinic, United States)
"Targeted Metabolomics of Gut Derived Microbial Metabolites in Alcohol-Associated Liver Disease"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Ida Villesen (Nordic Bioscience A/S, Denmark)
"ALPACA score: Development and Validation of a Score to Predict Risk of Liver-Related Events in Early Alcohol-Related Liver Disease"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:25 pm
Kristofer Fritz (University of Colorado Anschutz Medical Campus, United States)
"Proteomic Analysis of Alcohol-Associated Hepatitis Reveals Glycoprotein NMB (GPNMB) as a Novel Hepatic Biomarker"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Therapeutic Concepts for Alcohol-Associated Organ Diseases
Discussion Leader: Suthat Liangpunsakul (Indiana University School of Medicine, United States)
7:30 pm - 7:50 pm
Chunhui Xu (Emory University School of Medicine, United States)
"Alcohol-induced Cardiac Injury and Human iPSC for Cardiac Cell Therapy"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Douglas Simonetto (Mayo Clinic College of Medicine, United States)
"Drug Targets for Treatment of Alcoholic Plus non-Alcoholic Steatohepatitis in Patients"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
Drayton Harvey (Keck School of Medicine of USC, United States)
"Folate Supplementation Protects Cardiac Outflow Tract Development from Synergistic Teratogenic Effects of Prenatal Alcohol Exposure and Notch Pathway Mutations"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
Marcelle Ribeiro (BIDMC -HMS, United States)
"NLRP3-Dependent ASC Specks Released by Hepatocytes and Macrophages Perpetuate Inflammation in Alcoholic Hepatitis"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
Trevor Fisher (Surrozen, United States)
"Pericentral Gene Expression and Proliferation, Two Features Impaired in Human Alcoholic Cirrhosis, are Stimulated by SZN-043 in a Chronic-Binge Alcoholic Hepatitis Model"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Leon Coleman (UNC-CH Bowles Center for Alcohol Studies, United States)
"Chronic Alcohol Blocks Efficacy of Anti-PD1 Immunotherapy in Mice and Humans"
9:25 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure