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Angiotensin (GRS)

Gordon Research Seminar

The RAAS: Unraveling Cardiovascular Disease Mechanisms

February 24 - 25, 2024

Chairs

and

Renaissance Tuscany Il Ciocco

Via Giovanni Pascoli

Lucca (Barga), Lucca, Italy

Venue and Travel Information

Conference Description

ATTENTION: The GRS bus picks up and drops off at the Florence Airport (FLR) only. GRC no longer has bus service to / from the Pisa Airport.

The Angiotensin GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The Angiotensin Gordon Research Seminar (GRS) offers a unique opportunity for young scientists at all levels to share novel data and innovative concepts in science. The 2024 seminar will focus on sharing knowledge of recent tools and breakthroughs to explore the Renin-Angiotensin-Aldosterone System (RAAS) in the pathophysiology of cardiovascular diseases. We will highlight the sex and racial disparities in hypertension involving the RAAS. The mentoring block emphasizes career development and provides a session to discuss important aspects such as grant writing and self-management. Moreover, it offers a one-to-one meeting with a mentor to discuss one's career.

Related Meeting

This GRS will be held in conjunction with the "Angiotensin" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:00 pm - 3:15 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:15 pm - 4:00 pm	Keynote Session: Breakthrough on Renin-Angiotensin System Discussion Leaders: and
3:15 pm - 3:25 pm	Introduction by Discussion Leader
3:25 pm - 3:55 pm	"Heterogeneous Nature of Renin Producing Cells"
3:55 pm - 4:00 pm	Discussion
4:00 pm - 5:30 pm	Poster Session
5:30 pm - 7:30 pm	Revealing Therapeutic Pathways for Drug Discovery: Exploring Molecular Targets of the Renin-Angiotensin-Aldosterone System Discussion Leaders: and
5:30 pm - 5:45 pm	"Counteracting Angiotensinogen Small Interfering Rna-Mediated Antihypertensive Effects with Reversir"
5:45 pm - 5:50 pm	Discussion
5:50 pm - 6:05 pm	"Novel AT2R Agonist and Compound 21 Inhibit Ex Vivo IPF Fibrogenesis in Human Precision Cut Lung Slices"
6:05 pm - 6:10 pm	Discussion
6:10 pm - 6:25 pm	"pH-sensor GPR68 Plays a Role in the Cardioprotective Effects of a High Fibre Diet"
6:25 pm - 6:30 pm	Discussion
6:30 pm - 6:45 pm	"Inhibition of Coagulation Factor XI Improves Vascular Dysfunction and Cardiac Function in Ischemia/Reperfusion Injury in Mice with Excess Neurohormonal Activation"
6:45 pm - 6:50 pm	Discussion
6:50 pm - 7:05 pm	"Unravelling Soluble (Pro)Renin Receptor-Mediated Maternal Endothelial Dysfunction in Preeclampsia"
7:05 pm - 7:10 pm	Discussion
7:10 pm - 7:25 pm	"Afferent Regulation of Hindbrain Aldosterone-Sensing Neurons by the Central Amygdala"
7:25 pm - 7:30 pm	Discussion
8:00 pm - 9:00 pm	Dinner
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Unveiling Angiotensin Dynamics: Insights into Diverse Frontiers of Health and Disease Discussion Leaders: and
9:00 am - 9:10 am	Introduction by Discussion Leader
9:10 am - 9:25 am	"ACE1 and ACE2 Activity as Hallmark of RAS Dysregulation is Key in Characterising COVID-19 Severity in a South African Cohort"
9:25 am - 9:35 am	Discussion
9:35 am - 9:50 am	"Aldosterone-Mediated Sodium Appetite Requires Mineralocorticoid Receptor Expression by Hindbrain HSD2 Neurons"
9:50 am - 10:00 am	Discussion
10:00 am - 10:15 am	"Autoantibodies Targeting GPCRs and RAS-Related Molecules Increase with the Accumulation of COVID-19 Symptoms"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	"N-Domain Inhibition of the Angiotensin-Converting Enzyme is Sufficient to Elevate Concentrations of Met-Enkephalin-Arg-Phe in Brain Tissue"
10:35 am - 10:40 am	Discussion
10:40 am - 11:00 am	General Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Finding Your Path in Science Discussion Leaders: and
1:30 pm - 2:30 pm	Panel Discussion Finding Your Path in Science
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

Contributors

Research reported in this publication was supported by the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Number R13HL172578. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

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Conference History Angiotensin

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