Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Fluorine Biocatalysis: Bringing Halogens into the Chemistry of Living Cells
Fluorine is a key element for the synthesis of molecules broadly used in medicine, agriculture and materials. Adding fluorine atoms onto organic structures is a unique strategy for tuning molecular properties—yet organofluorines are rarely found in Nature, and approaches to integrate fluorometabolites into the chemistry of living cells are scarce. In this talk, Prof. Pablo Nikel will also discuss how synthetic metabolism can be implemented to expand the chemical landscape of bacteria, providing alternative biosynthetic strategies for fluorinated building-blocks.
3:45 pm - 4:15 pm
"Fluorine Biocatalysis: Bringing Halogens into the Chemistry of Living Cells"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Reactions, Techniques and the Catering of New Functionalities
7:30 pm - 7:40 pm
"Engineering an Efficient and Enantioselective Enzyme for the Morita–Baylis–Hillman Reaction"
7:40 pm - 7:45 pm
Discussion
7:45 pm - 7:55 pm
"Carbene Transferase Catalyzed One-Carbon Ring Expansions of Strained Nitrogen Heterocycles for the Synthesis of Highly Enantioenriched Azetidine Compounds"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 8:10 pm
"Mapping the Fitness Landscape of an Imine Reductase Using Long-Read Deep Mutational Scanning"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:25 pm
"Nature-Inspired Engineering of an Artificial Ligase Enzyme by Domain Fusion"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:40 pm
"Engineering Glycosyltransferases to Manufacture Non-Toxic Antifungals"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 8:55 pm
"Controlling Click Chemistry with Extracellular Electron Transfer"
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:10 pm
"Engineering a Non-Natural Photoenzyme for Improved Photon Efficiency"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"LightZymes: Artificial Enzymes Catalyzing Abiological Reactions by Photosensitizer Amino Acids"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
The "Multi" in Advanced Biocatalysis
9:00 am - 9:15 am
"Enzymatic Pathway Elucidation of Marine Polysaccharide Degradation"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
"Toward Engineering an Efficient and Thermostable a-Amino Ester Hydrolase (AEH): Minimizing Substrate Inhibition and Deactivation for Continuous Production of Cephalexin"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
"Bio-Based Synthesis of Metaraminol Using Microbially Produced Precursors and Reactive In Situ Product Removal"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
"Generating Superior Enzymes for Biofuel Production by Microfluidic-Based HTS"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
"A Chemoenzymatic Synthesis of the Mycobacterial Galactan"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"Machine Learning-Guided Optimization of the New-to-Nature CO2 -Fixation Cycle CETCH"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Career Paths in Science
1:30 pm - 2:30 pm
Panel Discussion
Career Paths in Science
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
