Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Ecology and Epidemiology of Pathogenic Spirochetes
Discussion Leader: Christine Petersen (University of Iowa, United States)
7:40 pm - 8:00 pm
Michael Marks (London School of Hygiene & Tropical Medicine, United Kingdom)
"Unravelling The Epidemiology of Treponema Pallidum"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:30 pm
Ryan Rego (Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic)
"Disentangling The Twisted Complexity of Borrelia burgdorferi sensu lato in Europe"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:55 pm
Short Talk Selected from Poster Abstracts
8:55 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Claudia Munoz-Zanzi (University of Minnesota, United States)
"Leptospirosis as an Outbreak-Prone Yet Neglected Disease Within an Island Ecological System"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Exploring The Post-Genomic World of Spirochetes
Discussion Leader: Frank Yang (Indiana University School of Medicine, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Alex Greninger (University of Washington, United States)
"Functional Genomics in T. pallidum"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Constantin Takacs (Northeastern University, United States)
"Organization and Segregation of A Highly Segmented Bacterial Genome"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
Short Talk Selected from Poster Abstracts
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Dave Wagner (Northern Arizona University, United States)
"Culture-Independent Tools for Genomic and Genetic Characterization of Pathogenic Leptospira : DNA Capture and Enrichment and Amplicon Sequencing"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:55 am
Discussion
11:55 am - 12:15 pm
Kay Nieselt (University of Tübingen, Germany)
"Computational and Visual Analytics Approaches to Reconstruct and Analyse The Genomic Landscape of Treponema pallidum "
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Christine Petersen (University of Iowa, United States) and Ashley Groshong (NIAID/DIR, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Signaling and Gene Regulation in Spirochetes
Discussion Leader: Mollie Jewett (University of Central Florida College of Medicine, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Philip Adams (National Institutes of Health, United States)
"Transcriptomic Studies Reveal Unexpected B. burgdorferi Regulators"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Troy Bankhead (Washington State University, United States)
"A Potential Role for vlsE Transcription in the Gene Conversion Mechanism in Borrelia burgdorferi "
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Short Talk Selected from Poster Abstracts
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Ching Wooen Sze (Virginia Commonwealth University, United States)
"CheA1 , A Chemosensory-Like Histidine Kinase Dispensable for Bacterial Chemotaxis but Regulates The Virulence of Borrelia burgdorferi "
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Host Responses in Spirochete Infections
Discussion Leader: Caroline Cameron (University of Victoria, Canada)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Maria Gomes-Solecki (The University of Tennessee Health Science Center, United States)
"Immune Modulators of Leptospira Pathogenesis in Mice"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Ellie Putz (USDA ARS NADC, United States)
"Peromyscus Deer Mice: A Novel Rodent Model of Acute Leptospirosis"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
Short Talk Selected from Poster Abstracts
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Jenny Hyde (Texas A&M University , United States)
"Pursuing the Bacterial and Host Mechanisms Governing Borrelia burgdorferi -Related Type I Interferon Responses"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:55 am
Discussion
11:55 am - 12:15 pm
Artem Rogovskyy (Texas A&M University, United States)
"In Search for Animal Models for Spirochetal Vector-Borne Diseases"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Spirochetes in Their Vectors and Reservoirs
Discussion Leader: Sukanya Narasimhan (Yale University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Eric Burrough (Iowa State University, United States)
"Brachyspira spp. Infections in Animals"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Sreekumari Rajeev (University of Tennessee, United States)
"Leptospira Infection in Reservoir Hosts: Challenges in Surveillance and Detection"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Short Talk Selected from Poster Abstracts
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Jannelle Couret (University of Rhode Island, United States)
"Borrelia Burgdorferi as A Beneficial Symbiont? An Arthropod-Centric View of Host-Microbe Interactions in A Vector-Borne Disease System"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Spirochetes-Host Interactions
Discussion Leader: Brian Stevenson (University of Kentucky, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Jenifer Coburn (Medical College of Wisconsin, United States)
"Interactions of Leptospira and Host: Still Greek to Us"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Utpal Pal (University of Maryland, College Park, United States)
"Borrelia Burgdorferi-Host Interactions as Novel Antimicrobial Strategies"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
Short Talk Selected from Poster Abstracts
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Kazuyuki Ishihara (Tokyo Dental College, Japan)
"The Effect of Responses Against Environmental Stress on The Pathogenicity of Treponema denticola "
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Dan Drecktrah (University of Montana, United States)
"Metabolic Regulation of The Carbonyl Stress Pathway in Lyme Disease and Relapsing Fever Borrelia Species"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Patrick Secor (University of Montana, United States)
"Characterization and Genomic Analysis of Borrelia burgdorferi Bacteriophages"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Membrane Proteins and Endoflagella in Spirochetes
Discussion Leader: J Christopher Fenno (University of Michigan School of Dentistry, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Wolfram Zückert (University of Kansas School of Medicine, United States)
"Role and Structure-Function of Lol and Lpt Pathways in Borrelia Envelope Biogenesis"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Kalvis Brangulis (Latvian Biomedical Research and Study Centre, Latvia)
"The Uniqueness of Spirochetes at the Molecular Level: Structural Insights into Lyme Borreliae Membrane-Associated Proteins"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Short Talk Selected from Poster Abstracts
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Charles Wolgemuth (University of Arizona, United States)
"The Biophysics of Leptospira Motility"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Translating Discoveries into Medical Applications for Patients
Discussion Leader: Monica Embers (Tulane National Primate Research Center, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:25 am
Nicholas Mantis (Wadsworth Center, New York State Department of Health, United States)
"Mechanisms of Immunity to Borrelia burgdorferi Revealed Through Structures of OspC-Antibody Complexes"
9:25 am - 9:35 am
Discussion
9:35 am - 9:55 am
Joppe Hovius (Amsterdam UMC, The Netherlands)
"(Google) Translating Knowledge on Tick-Host-Pathogen Interactions into Preventive and Diagnostic Interventions for Human Tick-Borne Diseases"
9:55 am - 10:05 am
Discussion
10:05 am - 10:20 am
Short Talk Selected from Poster Abstracts
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Arlene C. Seña (University of North Carolina at Chapel Hill, United States)
"Genomic Diversity of Treponema Pallidum Among Early Syphilis Patients Enrolled in A Global Consortium for Syphilis Vaccine Development"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Short Talk Selected from Poster Abstracts
11:45 am - 11:55 am
Discussion
11:55 am - 12:15 pm
Elsio Wunder Jr. (University of Connecticut, United States)
"From The Field To The Bench, and Back - Translational Research on Leptospirosis to Improve Prevention and Diagnostic"
12:15 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
New Technologies Leading To Insights in Spirochete Research
Discussion Leader: George Chaconas (University of Calgary, Canada)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 7:55 pm
Diane Edmondson (McGovern Medical School, University of Texas Health Science Center at Houston, United States)
"Dissecting Nutritional and Metabolic Pathways in Treponema pallidum "
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:25 pm
Luis Guilherme Fernandes (Instituto Butantan, Brazil)
"Recent Advances in Leptospira spp. Genetic Manipulation"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
Short Talk Selected from Poster Abstracts
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Adriana Marques (LCIM/NIAID/NIH, United States)
"Persistent Symptoms after Antibiotic Therapy for Lyme Disease – What's Past is Prologue"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure