Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Keynote Session: Translational Chemoproteomics
Discussion Leader: Alexander Hurben (University of Minnesota Twin Cities, United States)
3:45 pm - 4:20 pm
Benjamin Cravatt (The Scripps Research Institute, United States)
"Activity-Based Proteomics – Protein and Ligand Discovery on a Global Scale"
4:20 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemical Tools to Interrogate Biology
Discussion Leader: Christian Stieger (Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin e.V. (FMP) , Germany)
7:30 pm - 7:45 pm
Carly Schissel (University of California, Berkeley, United States)
"Post-Translational Chemical Manipulation of Non-Natural Ribosomal Products via Acyl Rearrangement"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
Colin Swenson (University of Chicago, United States)
"Targeting Myc Activity Using Modular bHLH-Derived Synthetic Transcriptional Repressors"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
Taia Wu (University of California - San Francisco, United States)
"Conformationally Responsive Dyes Enable Protein-Adaptive Differential Scanning Fluorimetry"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
Amanda Wiggenhorn (Stanford University, United States)
"A Class of Secreted Mammalian Peptides with Potential to Expand Cell-Cell Communication"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
Stephanie Smelyansky (Massachusetts Institute of Technology, United States)
"Exploiting Thioether Reactivity for Labeling Mycobacterial Glycans"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
Jack McCann (UC Berkeley, United States)
"Transfer Tuning: Turn-on Voltage-Sensitive Indicators for Hyperpolarized Membranes"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Omics Approaches
Discussion Leader: Claire Harmange Magnani (The Broad Institute, United States)
9:00 am - 9:15 am
Cong Tang (Instituto de Medicina Molecular, Portugal)
"Measuring Humoral Immune Response to Cancer Development and Treatment via Plasma Amino Acid Signatures by Utilizing Bioorthogonal Chemistry and Machine Learning"
9:15 am - 9:20 am
Discussion
9:20 am - 9:35 am
Sharon Chen (University of California, Irvine, United States)
"Chemically Triggered Bioorthogonal Probes to Tag RNA Structures"
9:35 am - 9:40 am
Discussion
9:40 am - 9:55 am
Christopher Travis (UNC Chapel Hill Department of Chemistry, United States)
"Evaluation of the Differential Binding Preferences of Histone Trimethyllysine Reader Proteins"
9:55 am - 10:00 am
Discussion
10:00 am - 10:15 am
Qiwen Su (Boston College, United States)
"CRISPR-Mediated Intracellular Selection of RNA Aptamers"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
Muhammad Murtaza Hassan (Stanford University, United States)
"Template-Assisted Covalent Modification of DCAF16 Underlies Activity of BRD4 Molecular Glue Degraders"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
Ethan Toriki (UC Berkeley, United States)
"Rational Chemical Design of Molecular Glue Degraders"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Careers at the Interface of Chemistry and Biology
Discussion Leaders: Lindsay Guzman (Stanford University, United States) and Steve Knutson (Princeton University, United States)
1:30 pm - 2:05 pm
Wendy Young (Advisor Google Ventures & former SVP Genentech, Drug Discovery , United States)
"Adventures in Drug Hunting"
2:05 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
