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Bioorganic Chemistry (GRS)

Gordon Research Seminar

Interrogating Complex Biological Systems to Drive Therapeutic and Basic Science Discoveries

June 8 - 9, 2024

Chairs

and

Proctor Academy

204 Main Street

Andover, New Hampshire, United States

Venue and Travel Information

Conference Description

The Bioorganic Chemistry GRS provides a unique forum for young doctoral and post-doctoral researchers to present their work, discuss new methods, cutting edge ideas, and pre-published data, as well as to build collaborative relationships with their peers. Experienced mentors and trainee moderators will facilitate active participation in scientific discussion to allow all attendees to be engaged participants rather than spectators.

The 2024 Bioorganic Gordon Research Seminar will focus on innovations in chemical tool design and the implementation of these probes and technologies for visualizing and understanding complex biological processes as well as leveraging these discoveries to drive therapeutic development. This GRS will include two poster sessions, two sessions of original research talks by graduate students and post-docs, panel(s) on mentorship and career development, and a keynote lecture. Additionally, there will be ample opportunity to have one-on-one conversations during dinner, breakfast, and poster sessions.

Related Meeting

This GRS will be held in conjunction with the "Bioorganic Chemistry" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm	Arrival and Check-in
3:30 pm - 3:45 pm	Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm	Keynote Session: Targeting the Undruggable Proteome Discussion Leader:
3:45 pm - 4:20 pm	"Learning about Druggability Using Reversibly Covalent Fragments"
4:20 pm - 4:30 pm	Discussion
4:30 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Chemical Probes to Interrogate Biology Discussion Leader:
7:30 pm - 7:45 pm	"TrogoTACs: Bispecific Chimeras for Targeted Protein Transfer"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:05 pm	"A Far-Red Fluorescent Probe for Detection of Gram-Positive Bacteria in Patient Samples"
8:05 pm - 8:10 pm	Discussion
8:10 pm - 8:25 pm	"Development of Small Molecule and Antibody Adaptors for Programming of Universal CAR T Cells"
8:25 pm - 8:30 pm	Discussion
8:30 pm - 8:45 pm	"Investigation of Photoresponsive Azobenzene as a Structural Modulator of Disease Relevant RNA"
8:45 pm - 8:50 pm	Discussion
8:50 pm - 9:05 pm	"A Long-Range Recruitment Mechanism for mTORC2 Phosphorylation of Akt"
9:05 pm - 9:10 pm	Discussion
9:10 pm - 9:25 pm	"Engineering CIRTS to Rebalance Protein Expression in Gene Dosage Disorders"
9:25 pm - 9:30 pm	Discussion
Sunday
7:30 am - 8:30 am	Breakfast
9:00 am - 11:00 am	Chemical Biology Discussion Leader:
9:00 am - 9:15 am	"Mapping Metabolite and Metal Ion-Protein Interactomes using Functional DNA-Based Proximity Labeling"
9:15 am - 9:20 am	Discussion
9:20 am - 9:35 am	"Juggler: Efficient Optimization of Ligand Matching towards Automating Ultra-Large-Scale Virtual Screens"
9:35 am - 9:40 am	Discussion
9:40 am - 9:55 am	"Autonomous Phenotype-Directed Discovery of Chemical Probes"
9:55 am - 10:00 am	Discussion
10:00 am - 10:15 am	"Photochemical Regulation of Translation via Molecular Recognition-Based Reversible Photo-Crosslinking Probe"
10:15 am - 10:20 am	Discussion
10:20 am - 10:35 am	"An Allosteric Site in Cyclin E-CDK2 Complexes Mapped by Paralog Hopping with Covalent Probes"
10:35 am - 10:40 am	Discussion
10:40 am - 10:55 am	"High-Throughput Methods to Measure RNA Folding Thermodynamics in Cells"
10:55 am - 11:00 am	Discussion
11:00 am - 12:30 pm	Poster Session Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm	Lunch
1:30 pm - 2:30 pm	Mentorship Component: Careers at the Interface of Chemistry and Biology Discussion Leaders: and
1:30 pm - 2:30 pm	Panel Discussion Careers at the Interface of Chemistry and Biology
2:30 pm - 3:00 pm	Evaluation Period Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm	Seminar Concludes

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Conference History Bioorganic Chemistry

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