The Gordon Conference on “Cannabinoid Function in The CNS” in 2011, the fourth in its series, will present the most recent advances on the multitude of physiological and pathophysiological roles of this lipid signalling system in the CNS, and discuss provocative new ideas and hypotheses, helping to integrate endocannabinoid function into other major CNS signalling systems, both in adult physiology and in neural development, as well as in various disease states. The conference will bring together established investigators of various disciplines, such as chemistry, biochemistry, pharmacology, physiology and genetics, but will also give plenty of opportunities to young investigators and students from around of the world, in order to attract new prospective leaders to this exciting research area. Several poster presenters will be selected for podium presentations, thus giving researchers early in their career the opportunity to present their results to the whole audience. All speakers will be encouraged to discuss unpublished results, thus enhancing the aspects of novelty and cutting edge research. In the opening talk on Sunday evening, Pierre Magistrettí from the EPFL Lausanne, Switzerland, will address the metabolic coupling between glial cells and neurons and discuss plasticity processes regulated by neuron-glia interactions, a topic of great interest for the further understanding of endocannabinoid function in the entire brain. Further topics will include the role of the endocannabinoid system in neurodegenerative disorders, neuroimmune interactions, memory processing, pain, and feeding behaviour, but the meeting will focus also on endocannabinoid interactions with other signalling systems, dietary influences on endocannabinoid signalling, novel techniques for the study of endocannabinoid signalling, novel pharmacological and genetic tools, and studies on non-THC phytocannabinoids. The collegial atmosphere at the conference, with plenty of opportunities for informal gatherings in the afternoon, with leisure time and long poster sessions, and in the evening, will promote cross-disciplinary collaborations and likely unify the different disciplines applied to research on cannabinoid function in the CNS.