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Cannabinoid Function in the CNS

Gordon Research Conference

Cell Types, Synapses, Circuits and the Road to Novel Therapeutics

November 7 - 12, 2021

Chairs

and

Vice Chairs

and

Four Points Sheraton / Holiday Inn Express

1050 Schooner Drive

Ventura, California, United States

Venue and Travel Information

Conference Description

The Cannabinoid Function in the CNS Gordon Research Conference aims to provide a cornerstone platform for dissemination of the most innovative and high-impact discoveries in the field of cannabinoid biology as they relate to CNS function broadly defined. The 2021 meeting will focus on cutting-edge work describing the impact of both plant-derived cannabinoids and endogenous cannabinoid signaling systems on defined cell-types and neural circuits with an emphasis on how these fundamental discoveries fuel cannabinoid-based therapeutics development for psychiatric and neurological disease. The scope of the conference will span from cellular and molecular neuroscience to clinical trials and will provide a venue for scientists at all levels to learn, present their work, and network in an inclusive and welcoming environment.

Related Meeting

This GRC will be held in conjunction with the "Cannabinoid Function in the CNS" Gordon Research Seminar (GRS). Those interested in attending both meetings must submit an application for the GRS in addition to an application for the GRC. Refer to the associated GRS program page for more information.

Conference Program

Sunday
4:00 pm - 8:00 pm	Arrival and Check-in
6:00 pm - 7:00 pm	Dinner
7:30 pm - 7:40 pm	Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm	Keynote Session: Pathways to Novel Therapeutics: Pharmacological and Imaging Tools Discussion Leader:
7:40 pm - 8:25 pm	"New Chemical and Synthetic Biology Technologies"
8:25 pm - 8:35 pm	Discussion
8:35 pm - 9:20 pm	"PharmacoSTORM Super-Resolution Imaging"
9:20 pm - 9:30 pm	Discussion
Monday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Cannabinoids, Pain and Neurological Disease Discussion Leader:
9:00 am - 9:20 am	"Endocannabinoid and Paracannabinoid Control of the Transition from Acute to Chronic Pain"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Targeting the Endocannabinoid System to Suppress Neuropathic Pain"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Chronic THC Vapor Inhalation Effects on Thermal Hyperalgesia and Synaptic Transmission in the vlPAG of Rats with Chronic Inflammatory Pain"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"Normalization of Corticostriatal Synaptic Plasticity and Motor Learning in Huntington Disease Mice by Modulating Endocannabinoid Levels"
11:20 am - 11:30 am	Discussion
11:30 am - 11:45 am	"How Cannabidiol Modulates Brain Activity: Implications for Epilepsy"
11:45 am - 11:50 am	Discussion
11:50 am - 12:05 pm	"The Role of Cannabinoid Receptor 2 in Immune-Mediated Regulation of Alpha-Synuclein Aggregation"
12:05 pm - 12:10 pm	Discussion
12:10 pm - 12:25 pm	"Cognition, Connectivity and Cannabinoids in Autism Spectrum Disorder"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
3:00 pm - 4:00 pm	The GRC Power Hour™ The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring. Organizers: , and
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cannabinoids, Stress, Fear and PTSD Discussion Leader:
7:30 pm - 7:50 pm	"Central Role for Endocannabinoids in Stress-induced Fear Memory Generalization"
7:50 pm - 8:00 pm	Discussion
8:00 pm - 8:20 pm	"Prefrontal Circuit Mechanisms Mediating the Extinction of Conditioned Fear Responses"
8:20 pm - 8:30 pm	Discussion
8:30 pm - 8:50 pm	"Endocannabinoid Function Following Trauma Exposure in Humans"
8:50 pm - 9:00 pm	Discussion
9:00 pm - 9:20 pm	"Cannabinoid Modulation of Prolonged Exposure in PTSD"
9:20 pm - 9:30 pm	Discussion
Tuesday
7:30 am - 8:30 am	Breakfast
8:30 am - 9:00 am	Group Photo
9:00 am - 12:30 pm	Neurodevelopmental Impacts of Cannabinoids Discussion Leader:
9:00 am - 9:20 am	"Interactions Between Maternal Immune Activation and Phytocannabinoids on Brain Development"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Prenatal THC Exposure Disrupts Reward Circuit Transcriptomes in Adults"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Choose Your Destiny: Using Cannabis Vapor Self-Administration to Interrogate Enduring Effects of Maternal Cannabis Use"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:15 am	"The Placenta: Window into the Developmental Reprogramming Induced by Prenatal Cannabis Exposure"
11:15 am - 11:20 am	Discussion
11:20 am - 11:35 am	"Effects of Adolescent THC Exposure on Prefrontal Contributions to Complex Behavior"
11:35 am - 11:40 am	Discussion
11:40 am - 12:00 pm	"Cannabinoid Modulation Across Neurodevelopment: From Reward to Schizophrenia"
12:00 pm - 12:05 pm	Discussion
12:05 pm - 12:25 pm	"Improving Preclinical Models of Adolescent Cannabis Exposure"
12:25 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Cannabis in Humans Discussion Leader:
7:30 pm - 7:45 pm	"Sleep Duration and Sleep Quality in Chronic Cannabis Users and Non-Users"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:10 pm	"Studying Cannabis in the Wild: Acute Effects of High Potency Cannabis on Cognition"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"THC and CBD: The Endocannabinoid System and Clinical Outcomes"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 9:00 pm	"Human Studies Probing Cannabis Constituents for Pain: Looking Beyond Delta-9-THC"
9:00 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	"Effect of AEF0117, a Signaling Specific Inhibitor of the CB1 Receptor (CB1-SSi), on the Subjective Effects of Cannabis and Cannabis Self Administration in Participants with Cannabis Use Disorder"
9:25 pm - 9:30 pm	Discussion
Wednesday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Cannabinoids and Glial Cells Discussion Leader:
9:00 am - 9:20 am	"CB2 Receptors and the CNS Response to Peripheral Immune Activation"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Endocannabinoids as Sculptors of Developing Social Circuits"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Astrocyte-Mediated Synaptic Regulation by Endocannabinoids"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:10 am	"Conditional Inducible Deletion of CB1 Receptors on Ventral Tegmental Area Astrocytes Maladaptively Potentiates Calcium Mobilization and Curtails Motivation for Food Reward"
11:10 am - 11:15 am	Discussion
11:15 am - 11:25 am	"Adolescent High Dose THC-Induced Behavioral Lability in Adulthood Is Linked to Perturbations in Astrocytes"
11:25 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Astrocytic Cannabinoid Receptor Expression Is Associated with Stress Resilience vs. Vulnerability"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Endocannabinoids, Astrocytes and the Social Transmission of Stress"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:00 pm - 7:30 pm	Business Meeting Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm	Endocannabinoid Based Drug Development Discussion Leader:
7:30 pm - 7:45 pm	"Characterization of Glycerophosphodiesterase GDE4 in N-Acylethanolamine Biosynthesis"
7:45 pm - 7:50 pm	Discussion
7:50 pm - 8:10 pm	"The Development of Monoacylglycerol Lipase Inhibitors for the Treatment of Neurological and Psychiatric Disorders"
8:10 pm - 8:15 pm	Discussion
8:15 pm - 8:35 pm	"Modulation of Endocannabinoids as Potential Treatments for Mood and Anxiety Disorders. Clinical Results of FAAH Inhibition in Social Anxiety Disorder and MDD"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 9:00 pm	"Structure-Activity Relationships and Preclinical Efficacy of Cannabinoid Receptor Positive Allosteric Modulator"
9:00 pm - 9:05 pm	Discussion
9:05 pm - 9:25 pm	"Functional Fingerprints of Cannabinoids on Brain Activation and Connectivity Patterns in the Awake Mouse Brain"
9:25 pm - 9:30 pm	Discussion
Thursday
7:30 am - 8:30 am	Breakfast
9:00 am - 12:30 pm	Cannabinoids, Reward and Addiction Discussion Leader:
9:00 am - 9:20 am	"THC Vapor Self-Administration and Conditioned Reward"
9:20 am - 9:30 am	Discussion
9:30 am - 9:50 am	"Characterization of Spontaneous vs. Precipitated WIN55,212-2 Withdrawal: Implications for Relapse?"
9:50 am - 10:00 am	Discussion
10:00 am - 10:20 am	"Brain Imaging Investigations on the Role of FAAH in the Addiction Process"
10:20 am - 10:30 am	Discussion
10:30 am - 11:00 am	Coffee Break
11:00 am - 11:20 am	"The Role of the Endocannabinoid 2-AG in Regulating Opioid Reward"
11:20 am - 11:30 am	Discussion
11:30 am - 11:50 am	"Shifting Mechanisms of Synaptic Depression During Incubation of Cocaine Craving"
11:50 am - 12:00 pm	Discussion
12:00 pm - 12:20 pm	"Endocannabinoid Modulation of Cocaine-Memory Strength During Reconsolidation"
12:20 pm - 12:30 pm	Discussion
12:30 pm - 1:30 pm	Lunch
1:30 pm - 4:00 pm	Free Time
4:00 pm - 6:00 pm	Poster Session
6:00 pm - 7:00 pm	Dinner
7:30 pm - 9:30 pm	Keynote Session: Novel Synaptic Actions of Endocannabinoids and the Neuroscience of Social Behavior Discussion Leader:
7:30 pm - 8:00 pm	"CB1 Receptors Regulate Spatial Memory and Epilepsy via Multiple Synaptic Mechanisms"
8:00 pm - 8:05 pm	Discussion
8:05 pm - 8:35 pm	"Dynamics of CB1 Interneurons and Endocannabinoid Signaling in the Hippocampus In Vivo"
8:35 pm - 8:40 pm	Discussion
8:40 pm - 9:20 pm	"Neural Representations of Social Homeostasis"
9:20 pm - 9:30 pm	Discussion
Friday
7:30 am - 8:30 am	Breakfast
9:00 am	Departure

Contributors

Research reported in this publication was supported by the National Institute On Drug Abuse of the National Institutes of Health under Award Number R13DA047696. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Cannabinoid Function in the CNS (GRS)

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