Sunday
4:00 pm - 8:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: Pathways to Novel Therapeutics: Pharmacological and Imaging Tools
Discussion Leader: Yasmin Hurd (Icahn School of Medicine at Mount Sinai, USA)
7:40 pm - 8:25 pm
Bryan Roth (University of North Carolina at Chapel Hill, USA)
"New Chemical and Synthetic Biology Technologies"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:20 pm
Istvan Katona (Indiana University Bloomington, USA)
"PharmacoSTORM Super-Resolution Imaging"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cannabinoids, Pain and Neurological Disease
Discussion Leader: Nephi Stella (University of Washington, USA)
9:00 am - 9:20 am
Daniele Piomelli (University of California, Irvine, USA)
"Endocannabinoid and Paracannabinoid Control of the Transition from Acute to Chronic Pain"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Andrea Hohmann (Indiana University, USA)
"Targeting the Endocannabinoid System to Suppress Neuropathic Pain"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Nicholas Gilpin (LSU Health Sciences Center New Orleans, USA)
"Chronic THC Vapor Inhalation Effects on Thermal Hyperalgesia and Synaptic Transmission in the vlPAG of Rats with Chronic Inflammatory Pain"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Lynn Raymond (University of British Columbia, Canada)
"Normalization of Corticostriatal Synaptic Plasticity and Motor Learning in Huntington Disease Mice by Modulating Endocannabinoid Levels"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Simon Chamberland (New York University, USA)
"How Cannabidiol Modulates Brain Activity: Implications for Epilepsy"
11:45 am - 11:50 am
Discussion
11:50 am - 12:05 pm
Valerie Joers (University of Florida, USA)
"The Role of Cannabinoid Receptor 2 in Immune-Mediated Regulation of Alpha-Synuclein Aggregation"
12:05 pm - 12:10 pm
Discussion
12:10 pm - 12:25 pm
Debra Karhson (University of Texas Permian Basin, USA)
"Cognition, Connectivity and Cannabinoids in Autism Spectrum Disorder"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Yasmin Hurd (Icahn School of Medicine at Mount Sinai, USA), Angeline Dukes (Black In Neuro, USA) and Nicholas Gilpin (LSU Health Sciences Center New Orleans, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cannabinoids, Stress, Fear and PTSD
Discussion Leader: Beat Lutz (Leibniz Institute for Resilience Research, Germany)
7:30 pm - 7:50 pm
Sylvie Lesuis (SickKids Hospital, University of Toronto, Canada)
"Central Role for Endocannabinoids in Stress-induced Fear Memory Generalization"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Conor Liston (Weill Cornell Medicine, USA)
"Prefrontal Circuit Mechanisms Mediating the Extinction of Conditioned Fear Responses"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Leah Mayo (Linköping University, Sweden)
"Endocannabinoid Function Following Trauma Exposure in Humans"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Christine Rabinak (Wayne State University, USA)
"Cannabinoid Modulation of Prolonged Exposure in PTSD"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Neurodevelopmental Impacts of Cannabinoids
Discussion Leader: Miriam Melis (University of Cagliari, Italy)
9:00 am - 9:20 am
Ken Mackie (Indiana University, USA)
"Interactions Between Maternal Immune Activation and Phytocannabinoids on Brain Development"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Mary Kay Lobo (University of Maryland School of Medicine, USA)
"Prenatal THC Exposure Disrupts Reward Circuit Transcriptomes in Adults"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Ryan McLaughlin (Washington State University, USA)
"Choose Your Destiny: Using Cannabis Vapor Self-Administration to Interrogate Enduring Effects of Maternal Cannabis Use"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:15 am
Anissa Bara (Icahn School of Medicine at Mount Sinai, USA)
"The Placenta: Window into the Developmental Reprogramming Induced by Prenatal Cannabis Exposure"
11:15 am - 11:20 am
Discussion
11:20 am - 11:35 am
Sierra Stringfield (University of Pittsburgh, USA)
"Effects of Adolescent THC Exposure on Prefrontal Contributions to Complex Behavior"
11:35 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Jibran Khokhar (University of Guelph, Canada)
"Cannabinoid Modulation Across Neurodevelopment: From Reward to Schizophrenia"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:25 pm
Stephen Mahler (University of California, Irvine, USA)
"Improving Preclinical Models of Adolescent Cannabis Exposure"
12:25 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Cannabis in Humans
Discussion Leader: Harriet de Wit (University of Chicago, USA)
7:30 pm - 7:45 pm
Nicole Bowles (Oregon Health and Science University, USA)
"Sleep Duration and Sleep Quality in Chronic Cannabis Users and Non-Users"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:10 pm
Carrie Cuttler (Washington State University, USA)
"Studying Cannabis in the Wild: Acute Effects of High Potency Cannabis on Cognition"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Kent Hutchison (University of Colorado, USA)
"THC and CBD: The Endocannabinoid System and Clinical Outcomes"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Ziva Cooper (UCLA Cannabis Research Initiative, USA)
"Human Studies Probing Cannabis Constituents for Pain: Looking Beyond Delta-9-THC"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Margaret Haney (Columbia University Irving Medical Center, USA)
"Effect of AEF0117, a Signaling Specific Inhibitor of the CB1 Receptor (CB1-SSi), on the Subjective Effects of Cannabis and Cannabis Self Administration in Participants with Cannabis Use Disorder"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cannabinoids and Glial Cells
Discussion Leader: Giovanni Marsicano (INSERM U1215, France)
9:00 am - 9:20 am
Cecilia Hillard (Medical College of Wisconsin, USA)
"CB2 Receptors and the CNS Response to Peripheral Immune Activation"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Margaret McCarthy (University of Maryland School of Medicine, USA)
"Endocannabinoids as Sculptors of Developing Social Circuits"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Alfonso Araque (University of Minnesota, USA)
"Astrocyte-Mediated Synaptic Regulation by Endocannabinoids"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:10 am
Lanyuan Zhang (University of Maryland, Baltimore, USA)
"Conditional Inducible Deletion of CB1 Receptors on Ventral Tegmental Area Astrocytes Maladaptively Potentiates Calcium Mobilization and Curtails Motivation for Food Reward"
11:10 am - 11:15 am
Discussion
11:15 am - 11:25 am
Jacqueline-Marie Ferland (Icahn School of Medicine at Mount Sinai, USA)
"Adolescent High Dose THC-Induced Behavioral Lability in Adulthood Is Linked to Perturbations in Astrocytes"
11:25 am - 11:30 am
Discussion
11:30 am - 11:50 am
Caroline Menard (Université Laval, Canada)
"Astrocytic Cannabinoid Receptor Expression Is Associated with Stress Resilience vs. Vulnerability"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Jaideep Bains (University of Calgary, Canada)
"Endocannabinoids, Astrocytes and the Social Transmission of Stress"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Endocannabinoid Based Drug Development
Discussion Leader: Ruth Ross (University of Toronto, Canada)
7:30 pm - 7:45 pm
Tom van der Wel (Leiden University, The Netherlands)
"Characterization of Glycerophosphodiesterase GDE4 in N-Acylethanolamine Biosynthesis"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:10 pm
Jackie Blankman (Lundbeck La Jolla Research Center Inc, USA)
"The Development of Monoacylglycerol Lipase Inhibitors for the Treatment of Neurological and Psychiatric Disorders"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:35 pm
Mark Schmidt (Janssen Pharmaceutica, N.V., Belgium)
"Modulation of Endocannabinoids as Potential Treatments for Mood and Anxiety Disorders. Clinical Results of FAAH Inhibition in Social Anxiety Disorder and MDD"
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:00 pm
Robert Laprairie (University of Saskatchewan, Canada)
"Structure-Activity Relationships and Preclinical Efficacy of Cannabinoid Receptor Positive Allosteric Modulator"
9:00 pm - 9:05 pm
Discussion
9:05 pm - 9:25 pm
Zsolt Lenkei (INSERM, France)
"Functional Fingerprints of Cannabinoids on Brain Activation and Connectivity Patterns in the Awake Mouse Brain"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Cannabinoids, Reward and Addiction
Discussion Leader: Joseph Cheer (University of Maryland School of Medicine, USA)
9:00 am - 9:20 am
Elise Weerts (Johns Hopkins University School of Medicine, USA)
"THC Vapor Self-Administration and Conditioned Reward"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Sade Spencer (University of Minnesota, USA)
"Characterization of Spontaneous vs. Precipitated WIN55,212-2 Withdrawal: Implications for Relapse?"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Isabelle Boileau (University of Toronto, Canada)
"Brain Imaging Investigations on the Role of FAAH in the Addiction Process"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Francis Lee (Weill Cornell Medicine, USA)
"The Role of the Endocannabinoid 2-AG in Regulating Opioid Reward"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Marina Wolf (Oregon Health & Science University, USA)
"Shifting Mechanisms of Synaptic Depression During Incubation of Cocaine Craving"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Rita Fuchs (Washington State University, USA)
"Endocannabinoid Modulation of Cocaine-Memory Strength During Reconsolidation"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Novel Synaptic Actions of Endocannabinoids and the Neuroscience of Social Behavior
Discussion Leader: Raffaella Tonini (Istituto Italiano di Tecnologia (IIT), Italy)
7:30 pm - 8:00 pm
Pablo Castillo (Albert Einstein College of Medicine, USA)
"CB1 Receptors Regulate Spatial Memory and Epilepsy via Multiple Synaptic Mechanisms"
8:00 pm - 8:05 pm
Discussion
8:05 pm - 8:35 pm
Ivan Soltesz (Stanford University, USA)
"Dynamics of CB1 Interneurons and Endocannabinoid Signaling in the Hippocampus In Vivo "
8:35 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Kay Tye (Salk Institute for Biological Studies, USA)
"Neural Representations of Social Homeostasis"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure
