SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Glycomimetics |
| Discussion Leader: George O'Doherty (Northeastern University) |
7:35 pm - 8:05 pm | John Magnani (Glycomimetics, Inc.) "GMI-1070: A Small Molecule Glycomimetic Antagonist of the Selectins in Phase II Clinical Trials for Vaso-occlusive Crisis in Sickle Cell Disease" |
8:05 pm - 8:15 pm | Discussion |
8:15 pm - 8:45 pm | Paul Murphy (National University of Ireland) "Anomerization and the Synthesis of Glycomimetics" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Beat Ernst (University of Basel) "Lectins as Therapeutic Targets" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Conformational Analysis/NMR Spectroscopy |
| Discussion Leader: Joseph Barchi (NCI Frederick) |
9:00 am - 9:30 am | Julie Bouckaert (Vrije Universiteit Brussel) "Structural and Thermodynamic Basis of Mannose Binding to the Type-1 Fimbrial Adhesin of Escherichia coli" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Christoph Rademacher (Scripps Research Institute) "NMR Experiments Guiding the Design of Multivalent Inhibitors Against Norovirus Cell Entry" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break / Group Photo |
10:50 am - 11:20 am | Mari DeMarco (Washington University) "3D Structure Determination of Dynamic Glycolipids in Biologically Relevant Environments:
Challenges & Methods" |
11:20 am - 11:30 am | Discussion |
11:30am - 11:50 am | Selected Poster Talks |
11:50 am - 12:30 pm | Roundtable Topic Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Synthetic Carbohydrate Chemistry |
| Discussion Leader: Alexei Demchenko (University of Missouri) |
7:30 pm - 8:00 pm | Beatrice Collet (LuCella Biosciences, Inc.) "Automated Oligosaccharide Synthesis" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Takashi Takahashi (Tokyo Institute of Technology) "Synthesis of Biologically Important Oligosaccharides Toward Chemical Glycobiology Study" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | David Crich (University of Illinois) "Methodology Development and Physical Organic Chemistry: A Powerful Combination for Glycochemistry" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Synthetic Carbohydrate Chemistry |
| Discussion Leader: France-Isabelle Auzanneau (Guelph University) |
9:00 am - 9:30 am | Reko Leino (Åbo Akademi University) "Towards Immunostimulatory Oligosaccharides" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Hien Nguyen (University of Iowa) "Stereocontrolled Synthesis of 1,2-Cis-2-Aminosugars and Glycosyl Ureas" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Cristina De Meo (Southern Illinois University) "Chemical Sialylation: Traditional Challenges and Recent Advancements'" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Selected Poster Talks |
11:40 am - 12:30 pm | Roundtable Topic Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Chemical Glycobiology |
| Discussion Leader: Nicola Pohl (Iowa State University) |
7:30 pm - 8:00 pm | Suzanne Walker (Harvard Medical School) "Structure and Inhibition of Human O-GlcNac Transferase" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Chris Cairo (University of Alberta) "Substrate Specificity and Inhibition of Human Neuraminidase 3 (NEU3)" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Anna-Maria Papini (University of Florence) "The 'Chemical Reverse Approach' to Develop Glycopeptides as Synthetic Antigens Characterizing Autoantibodies as Biomarkers of Immune-mediated Neurodegenerative Diseases" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chemical Glycobiology |
| Discussion Leader: Xi Chen (UC Davis) |
9:00 am - 9:30 am | Jennifer Kohler (UT Southwestern Medical Center) |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Ben Davis (University of Oxford) "Sugars and Proteins" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:10 am | Daniel Kahne (Harvard University) "Lipopolysaccharide Transport and Assembly in Escherichia coli" |
11:10 am - 11:20 am | Discussion |
11:20 am - 11:40 am | Selected Poster Talks |
11:40 am - 12:30 pm | Roundtable Topic Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Glycoinformatics / Computational Simulations |
| Discussion Leader: Robert Woods (University of Georgia) |
7:30 pm - 8:00 pm | Nicolle Packer (Macquarie University) "UniCarb: Getting It All Together" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | David F. Green (Stony Brook University) "Carbohydrate-recognition by Anti-viral Lectins: New Insights from Computational Models" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Peter Kasson (Stanford University) "Receptor Binding by Influenza Virus: Using Computational Techniques to Extend Structural Data" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Vaccines |
| Discussion Leader: Willie Vann (FDA) |
9:00 am - 9:30 am | Andre Nikolaev (University of Dundee)
"From Phosphosaccharide Chemistry to Potential Anti-parasite and Anti-bacterial Carbohydrate Vaccines" |
9:30 am - 9:40 am | Discussion |
9:40 am - 10:10 am | Geert-Jan Boons (University of Georgia) "Carbohydrate-Based Multicomponent Vaccines" |
10:10 am - 10:20 am | Discussion |
10:20 am | Coffee Break |
10:50 am - 11:20 am | Francesco Berti (Novartis) "Structural Characterization of Carbohydrate-Based Conjugate Vaccines" |
11:20 am - 11:30 am | Discussion |
11:30 am - 11:40 am | Selected Poster Talks |
11:40 am - 12:30 pm | Roundtable Topic Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Emerging Applications in Glycoanalytics |
| Discussion Leader: Mingdi Yan (Portland State University) |
7:30 pm - 8:00 pm | John Nolan (LaJolla BioEngineering Institute) "Quantitative, Multiplexed Measurement of Glycan-Receptor Interactions" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | David Clemmer (Indiana University) "Developing Ion Mobility/Photodissociation/Mass Spectrometry Techniques for the Analysis of Carbohydrate Mixtures" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | John Klassen (University of Alberta) "Characterization of Protein-Carbohydrate Interactions Using Mass Spectrometry" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |