Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Enabling
Technologies for Functional Glycomics
Discussion Leader: Joseph Barchi (National Cancer Institute, NIH, USA)
7:40 pm - 8:05 pm
Richard Cummings (Beth Israel Deaconess Medical Center, Harvard Medical School, USA)
"Human Glycomics and Deciphering the Expression and Biological Recognition of Glycans"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Nicola Pohl (Indiana University, USA)
"A Systems Approach to Carbohydrate Synthesis and Analysis"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Jeffrey Gildersleeve (National Cancer Institute, NIH, USA)
"Exploiting Anti-Glycan Immunity to Improve Cancer Care"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glycosylation
and Synthetic Methodology
Discussion Leaders: Valentin Wittmann (University of Konstanz, Germany) and Biao Yu (Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China)
9:00 am - 9:25 am
Alexei Demchenko (University of Missouri-St. Louis, USA)
"From Stereocontrolled Glycosylation to the Automated Oligosaccharide Synthesis"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Antony Fairbanks (The University of Canterbury, New Zealand)
"Protecting Group Free Transformations of Reducing Sugars in Aqueous Solution"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Selected from Poster Abstracts: Xin-Shan Ye (Peking University, China)
"Photo-Induced Glycosylation Reactions"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Yasuhiro Kajihara (Osaka University, Japan)
"Synthesis of Glycoconjugates for Elucidation of Oligosaccharide Functions"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Jin-Song Yang (Sichuan University, China)
"Stereoselective Synthesis of Kdo Glycoside"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Clay Bennett (Tufts University, USA)
"Chemical Promoters for Controlling Selectivity in Glycosylation Reactions"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Cheng-Chung Wang (Institute of Chemistry, Academia Sinica, Taiwan)
"Chemistry on Protection and Functionalization of Free Sugars"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizer: Alyssa Pirinelli (University of Minnesota Morris, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemical
Glycobiology
Discussion Leader: Xi Chen (University of California, Davis, USA)
7:30 pm - 7:55 pm
Linda Hsieh-Wilson (California Institute of Technology, USA)
"Carbohydrate Recognition and Signaling in the Brain"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
James Paulson (The Scripps Research Institute, USA)
"Human Influenza Virus Receptors"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Jennifer Kohler (University of Texas Southwestern Medical Center, USA)
"Discovery of Host Cell Glycans Recognized by Bacterial Toxins"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Kamil Godula (University of California, San Diego, USA)
"Chemical Editing of the Glycocalyx to Influence Stem Cell Differentiation"
9:25 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Enzymatic
and Chemoenzymatic Assembly of Glycans
Discussion Leader: Peng George Wang (Georgia State University, USA)
9:00 am - 9:25 am
Hung-Wen Liu (University of Texas at Austin, USA)
"Biosynthetic Studies of Oxetanocin A"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Vladimir Kren (Czech Academy of Sciences, Czech Republic)
"Mutant Glycosyltransferases and Hexosaminidases in the Synthesis of Advanced Glycomaterials"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Selected from Poster Abstracts: Juergen Seibel (University of Wuerzburg, Germany)
"Switching Enzyme Specificity from Phosphate to Resveratrol Glucosylation via Domain-Shift"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Stephen Withers (University of British Columbia, Canada)
"Discovering New Glycosidases Through Metagenomics and Gene Synthesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Hongzhi Cao (Shandong University, China)
"Enzymatic Modular Assembly of Human Blood Antigens"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Ethan Goddard-Borger (Walter and Eliza Hall Institute, Australia)
"New Insights into the Process and Function of Tryptophan C-Mannosylation Provided by Yeast Engineered to Perform This Protein Modification"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Mads Clausen (Technical University of Denmark, Denmark)
"Synthesis and Application of Oligosaccharides Related to Plant Cell Wall Glycans"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Molecular Recognition in Protein-Carbohydrate Interactions
Discussion Leaders: Xing Chen (Peking University, China) and Lara Mahal (New York University, USA)
7:30 pm - 7:55 pm
Anne Imberty (CERMAV, CNRS, France)
"Microbial Lectins Binding to Lewis Glycotopes: Experimental and Computational Study"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Robert Sackstein (Harvard Medical School, USA)
"Glycosyltransferases as Tools to Identify Cell Surface Lactosaminyl Glycans"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Peng Wu (Scripps Research Institute, USA)
"Chemoenzymatic Detection of Glycans: Methods and Applications"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Zhongping Tan (University of Colorado Boulder, USA)
"Using Chemical Biology to Understand and Apply Protein O-Glycosylation"
9:25 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Carbohydrate Vaccines and Glyco-Immunology
Discussion Leaders: Xuefei Huang (Michigan State University, USA) and Steven Sucheck (The University of Toledo, USA)
9:00 am - 9:25 am
Peter Seeberger (Max-Planck-Institute of Colloids and Interfaces , Germany)
"From Biologicals to Pharmaceuticals: A Medicinal Chemistry Approach to Carbohydrate-Conjugate Vaccines Against Streptococcus pneumoniae and Other Bacteria"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Yan-Mei Li (Tsinghua University, China)
"Glycopeptide Vaccines for Cancer Immunotherapy"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Selected from Poster Abstracts: Wei Huang (Chinese Academy of Sciences, China)
"Real-Time Analysis on Drug-Antibody Ratio of Antibody-Drug Conjugates for Synthesis, Process Optimization, and Quality Control"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Peter Andreana (University of Toledo, USA)
"An Entirely Carbohydrate-Recognizing Monoclonal Antibody"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Selected from Poster Abstracts: Jillian Prendergast (Siamab Therapeutics, Inc., USA)
"Anti-Sialyl-Tn Monoclonal Antibody-Drug Conjugates (ADCs) Demonstrate Tumor Specificity In Vitro and In Vivo Antitumor Efficacy"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Selected from Poster Abstracts: Dapeng Zhou (Tongji University, China)
"Precision Mapping of MUC1 Glycopeptides Expressed by Non-Small Cell Carcinoma"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:10 pm
Selected from Poster Abstracts: Steven Townsend (Vanderbilt University, USA)
"Carbohydrate Involvement in Group B Streptococcus (GBS) Pathogenesis"
12:10 pm - 12:15 pm
Discussion
12:15 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Structural
Chemistry and Biology of Carbohydrates
Discussion Leader: Zhongwu Guo (University of Florida, USA)
7:30 pm - 7:55 pm
Robert Woods (University of Georgia, USA)
"Computational and Biophysical Insight into Glycan Specificity: The Role of Entropy and Avidity"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Yuriy Knirel (N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Russia)
"Capsular Polysaccharides of the Nosocomial Pathogen Acinetobacter baumannii : Structure, Genetics, and Cleavage by Bacteriophages"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:05 pm
Catherine Costello (Boston University School of Medicine, USA)
"Can Advances in Mass Spectrometry Unlock the Mysteries of Glycans?"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
Selected from Poster Abstracts: Jiaoyang Jiang (University of Wisconsin-Madison, USA)
"Structures of Human O-GlcNAcase and Its Complexes Reveal a New Substrate Recognition Mode"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
9:00 am - 12:30 pm
Synthetic
Probes for Deciphering Carbohydrate Functions
Discussion Leader: George O'Doherty (Northeastern University, USA)
9:00 am - 9:25 am
Yukishige Ito (RIKEN, Japan)
"Synthetic Substrates for the Analysis of Glycan Processing Enzymes in the ER"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Todd Lowary (University of Alberta, Canada)
"Synthesis of Designer Polysaccharides"
10:00 am - 10:10 am
Discussion
10:10 am - 10:20 am
Selected from Poster Abstracts: Suvarn Kulkarni (Indian Institute of Technology Bombay, India)
"Synthesis of Rare Sugar AAT Containing Bacterial Glycoconjugates"
10:20 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Eriks Rozners (Binghamton University, USA)
"Carbohydrate Chemistry for RNA Interference: Synthesis, Structure and Biological Activity of Amide-Linked RNA"
11:20 am - 11:30 am
Discussion
11:30 am - 11:55 am
Shang-Cheng Hung (Academia Sinica, Taiwan)
"Synthesis and Characterization of Specific Heparan Sulfate-Protein Interactions"
11:55 am - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Selected from Poster Abstracts: M. Carmen Galan (University of Bristol, United Kingdom)
"Palladium-Catalyzed Direct Stereoselective Synthesis of Deoxyglycosides from Glycals"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycans
in Biotechnology and Medicine
Discussion Leader: Philip Deshong (University of Maryland, College Park, USA)
7:30 pm - 7:55 pm
Jian Liu (University of North Carolina at Chapel Hill, USA)
"Developing an Enzyme-Based Approach to Synthetize Glycosaminoglycans"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Shin-Ichiro Nishimura (Hokkaido University, Japan)
"Nanomedicine Targeting Intracellular Glycoenzymes"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Selected from Poster Abstracts: Dennis Whitfield (Sussex Research Laboratories Inc, Canada)
"Glycosylation of a Subfragment Peptide of Type I Collagen"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
John Magnani (GlycoMimetics, Inc., USA)
"Three Different Glycomimetic Drugs in Clinical Trials for Inflammatory Disorders and Cancer"
9:20 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure