Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Glycans in COVID-19 and Other Emerging Diseases
Discussion Leader: Justin Ragains (Louisiana State University, United States)
7:40 pm - 8:05 pm
Jeffrey Gildersleeve (National Cancer Institute, NIH, United States)
"Carbohydrate-Binding Antibodies: Opportunities and Challenges"
8:05 pm - 8:15 pm
Discussion
8:15 pm - 8:40 pm
Max Crispin (University of Southampton, United Kingdom)
"Exploiting Pathogen Immune Evasion Strategies in Vaccine Design and Therapeutics"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Tania Lupoli (New York University, United States)
"Access to NDP-L-Sugars Informs a Strategy to Inhibit Bacteria-Specific Glycosyltransferases"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Chemical Synthesis of Complex Glycans
Discussion Leaders: George O'Doherty (Northeastern University, United States) and Pavel Nagorny (University of Michigan, United States)
9:00 am - 9:25 am
M. Carmen Galan (University of Bristol, United Kingdom)
"Catalytic Methods for the Synthesis of Deoxyglycoside Probes to Study Carbohydrate Mediated Interactions"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Jianglong Zhu (University of Toledo, United States)
"Synthesis of Bacterial Carbohydrate Antigens by Stereoselective Anomeric O-Alkylation"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
Laurence Mulard (INSTITUT PASTEUR, France)
"Tuning Synthetic Glycan Haptens Toward a Broad Coverage Shigella Conjugate Vaccine"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Clay Bennett (Tufts University, United States)
"Studies in Stereoselective Deoxy Sugar Oligosaccharide Synthesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Toshiki Nokami (Tottori University, Japan)
"Electrochemical Synthesis of Cyclic Oligosaccharides"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Pavan Kumar Kancharla (Indian Institute of Technology Guwahati, India)
"Strained/Frustrated Bronsted Pair Catalysis for the Stereoselective Glycoside Bond Formation"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Nicole Snyder (Davidson College, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycoimmunology and Vaccines
Discussion Leaders: Abram Axelrod (Purdue University, United States) and Steven Sucheck (The University of Toledo, United States)
7:30 pm - 7:55 pm
Zhongwu Guo (University of Florida, United States)
"Totally Synthetic Glycoconjugate Vaccines Against Cancer and Bacteria Using Lipid A Derivatives as Carrier Molecules"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
James Paulson (The Scripps Research Institute, United States)
"Siglecs as Glycoimmune Checkpoints for Suppressing Unwanted Immune Responses"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Jeffrey Gildersleeve (National Cancer Institute, NIH, United States)
"A Human, dPNAG-Specific Monoclonal Antibody Provides Protection from a Lethal S. aureus Challenge and Reveals Unique Biofilm Features"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Edward Ryan (Harvard University-Massachusetts General Hospital, United States)
"Immune Responses Targeting Bacterial O-Specific Polysaccharide During Enteric Infection, Lessons from Cholera"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Industrial Applications and Applied Glycoscience
Discussion Leaders: Susanne Striegler (University of Arkansas, United States) and Jennifer Koviach-Cote (Bates College, United States)
9:00 am - 9:25 am
Muthiah (Mano) Manoharan (Alnylam Pharmaceuticals, United States)
"How Glycochemistry and Glycocojugates Made Successful Nucleic Acid Therapeutics Possible"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
William Walkowicz (Chemitope Glycopeptide, United States)
"Gram-Scale Synthesis of a Glycopeptide Immunogen for an HIV Vaccine Clinical Trial"
9:45 am - 9:50 am
Discussion
9:50 am - 10:00 am
Flavio Schwarz (InterVenn Biosciences, United States)
"Blood Glycoproteomic Biomarkers Identify Metastatic Melanoma Patients with Reduced Clinical Benefit from Immune Checkpoint Inhibitor Therapy"
10:00 am - 10:05 am
Discussion
10:05 am - 10:15 am
Yanzhuang Wang (University of Michigan, United States)
"Exploring the Impact of Golgi Stack Formation on Glycosylation"
10:15 am - 10:20 am
Discussion
10:20 am - 10:55 am
Coffee Break
10:55 am - 11:20 am
Francesca Micoli (Gsk vaccines institute for global health, Italy)
"GMMA as Innovative Delivery System for Carbohydrates"
11:20 am - 11:30 am
Discussion
11:30 am - 11:40 am
Yoshiyuki Manabe (Osaka University, Japan)
"Development of Cancer Immunotherapy by Antibody Recruiting Using Antigen Glycans"
11:40 am - 11:45 am
Discussion
11:45 am - 11:55 am
Nicole Snyder (Davidson College, United States)
"Glycomacromolecules as Glycan Mimetics for Viral Targeting"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:30 pm
Poster Previews
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Chemical Glycobiology
Discussion Leaders: Charlie Fehl (Wayne State University, United States) and Lina Cui (University of Florida, United States)
7:30 pm - 7:55 pm
Stephen Withers (University of British Columbia, Canada)
"New Enzymes and New Mechanisms through Metagenomic Screening"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:30 pm
Linda Hsieh-Wilson (California Institute of Technology, United States)
"Decoding Glycosaminoglycans and Their Roles in Neuroplasticity"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 8:50 pm
Jiaoyang Jiang (University of Wisconsin-Madison, United States)
"A Novel Binding Site on the Cryptic Intervening Domain is a Motif-Dependent Regulator of O-GlcNAc Transferase"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Hung-Wen Liu (University of Texas at Austin, United States)
"Studies of the Biosynthesis of the Adenosine-Based Antibiotics Herbididins"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Glycoanalysis and Glycomics
Discussion Leaders: Amit Basu (Brown University, United States) and Joseph Barchi Jr. (National Cancer Institute, NIH, United States)
9:00 am - 9:25 am
Anne Dell (Imperial College London, United Kingdom)
"High Sensitivity N- and O-Glycomics: Insights into the Glycobiology of the Great Obstetrical Syndromes"
9:25 am - 9:35 am
Discussion
9:35 am - 10:00 am
Jesus Jimenez-Barbero (CIC bioGUNE, Spain)
"Breaking the Limits in Understanding Glycan Recognition by NMR"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 10:50 am
Susanne Striegler (University of Arkansas, United States)
"Developing Nanogels with Glyosidase Activity"
10:50 am - 10:55 am
Discussion
10:55 am - 11:05 am
Joseph Barchi Jr. (National Cancer Institute, NIH, United States)
"Fun with Thomsen and Friedenreich: Development of a Monoclonal Antibody to a TF-Antigen Containing Glycopeptide from Mucin-4"
11:05 am - 11:10 am
Discussion
11:10 am - 11:35 am
Ten Feizi (Imperial College London, United Kingdom)
"Multifaceted Approaches to Unraveling Glycan Recognition Systems"
11:35 am - 11:45 am
Discussion
11:45 am - 12:10 pm
Lara Mahal (University of Alberta, Canada)
"Rethinking the Paradigm: New Roles for Non-Coding RNA in Controlling the Glycome"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycans and Therapeutics
Discussion Leaders: Hao Xu (Brandeis University, United States) and Weiping Tang (University of Wisconsin-Madison, United States)
7:30 pm - 7:55 pm
Todd Lowary (Academia Sinica, Taiwan)
"Glycan Arrays, Diagnostics and Mycobacteriophages"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Hien Nguyen (WAYNE STATE UNIVERSITY, United States)
"Effects of Heparan Sulfate-Like Trisaccharide in Attenuating Stress Response and Inflammation Associated with Alzheimer’s Disease"
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:45 pm
David Vocadlo (Simon Fraser University, Canada)
"Chemical Biology Tools for Image-Based Quantification of Enzyme Activities Within Living Cells"
8:45 pm - 8:55 pm
Discussion
8:55 pm - 9:20 pm
Herman Overkleeft (Professor, The Netherlands)
"Activity-Based Glycosidase Profiling"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Enzymatic and Glycoconjugate Synthesis
Discussion Leaders: Suvarn Kulkarni (Indian Institute of Technology Bombay, India) and Lai-Xi Wang (University of Maryland College Park, United States)
9:00 am - 9:25 am
Xi Chen (University of California, Davis, United States)
"Process and Glycosyltransferase Engineering for Chemoenzymatic Synthesis of Carbohydrates and Glycoconjugates"
9:25 am - 9:35 am
Discussion
9:35 am - 9:45 am
Valentin Wittmann (University of Konstanz, Germany)
"Chemoselective Ligation Reactions for Metabolic Glycoengineering and the Preparation of Glycoconjugates"
9:45 am - 9:50 am
Discussion
9:50 am - 10:15 am
Yasuhiro Kajihara (Osaka University, Japan)
"Glycans on Proteins"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:05 am
Jia Niu (Boston College, United States)
"Polymer Chemistry Inspired Approaches to Polysaccharides and Glycomimetics for Material and Biological Discoveries"
11:05 am - 11:10 am
Discussion
11:10 am - 11:20 am
Mads Clausen (Technical University of Denmark, Denmark)
"Adventures in Anomeric Reactivity"
11:20 am - 11:25 am
Discussion
11:25 am - 11:35 am
Charlie Fehl (Wayne State University, United States)
"Spatiotemporal Chemical Tools to Functionally Probe Sugar Signaling in Cells and Disease"
11:35 am - 11:40 am
Discussion
11:40 am - 11:50 am
Lei Li (Georgia State University, United States)
"Regioselective I-Branching of Poly-LacNAc Glycans"
11:50 am - 11:55 am
Discussion
11:55 am - 12:20 pm
Jian Liu (University of North Carolina at Chapel Hill, United States)
"Development a LC-MS/MS Based Method to Analysis of Rare Heparan Sulfates Using Synthetic Isotopically Labeled Calibrants"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Glycans in Host-Microbe Interactions
Discussion Leaders: Myles Poulin (University of Maryland at College Park, United States) and Danielle Dube (Bowdoin College, United States)
7:30 pm - 7:55 pm
Willie Vann (U.S. Food and Drug Administration, United States)
"Capsules of Pathogenic Bacteria: Synthesis by Polysaccharide Polymerases"
7:55 pm - 8:05 pm
Discussion
8:05 pm - 8:15 pm
Katja Michael (University of Texas at El Paso, United States)
"Discovery of a-Gal-Containing Biomarkers for New World Leishmaniasis caused by L. Braziliensis "
8:15 pm - 8:20 pm
Discussion
8:20 pm - 8:30 pm
Chi-Kung Ni (Academia Sinica, Taiwan)
"Unusual Free Oligosaccharides in Human Bovine Caprine and Mouse Milk"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:45 pm
Suvarn Kulkarni (Indian Institute of Technology Bombay, India)
"Total Synthesis of Rare Sugar Containing Complex Oligosaccharides and Glycocojugates from Pathogenic Bacteria"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
Gerald Pier (Harvard Medical School/Brigham and Women's Hospital, United States)
"Role of the Conserved Microbial Surface Polysaccharide, Poly-N-acetyl Glucosamine (PNAG) in Pathogenesis of Microbiota-Driven Human Diseases"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure