Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Catecholaminergic Signaling During Behavior
7:40 pm - 8:20 pm
"Mechanistic Insights into the Vulnerability of the Nucleus Accumbens in Anxiety"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"What Are "States" in Reinforcement Learning?"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Genetics and Epigenetics of Catecholamine Neurons
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Protein Catecholaminylation in the Brain: Non-Canonical Roles for Dopamine in the Regulation of Neural Transcriptional Plasticity"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Dopamine-Dependent Transcriptional and Chromatin Dynamics in Brain Reward Circuits: Cause and Consequence"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Dynamic Consequences of Stress on VTA Development"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Cell Type-Specific and Spatially-Resolved Transcriptomic Signatures in the Human Locus Coeruleus"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Transcriptional Consequences of Fentanyl use in the Ventral Tegmental Area"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Molecular Pharmacology and Signaling in Catecholamine Systems
6:00 pm - 6:20 pm
"Morphine-Induced Increase in Neuropeptide Expression in Ventral Tegmental Area Dopaminergic Neurons"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Ion Channel Regulation of Dopaminergic Neurophysiology and Behavior"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Advancing Neurotherapeutics With In Vivo Neural Imaging"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Sex-Specific Regulation of Dopamine Release Mechanisms through Nicotinic Acetylcholine Receptors"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
New Tools to Probe Catecholaminergic Functions
9:00 am - 9:20 am
"A New Family of Genetically Encoded Catecholamines Probes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Visualizing and Perturbing Neuromodulator Signaling in Real Time"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
"Optical Nanosensors for Visualizing Dopamine Dynamics at the Resolution of a Single Bouton"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
"Manipulating the Catecholamine Connectome with DART"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Development of a Novel AAV Intersectional Strategy and it's Application Towards Exploring Locus Coeruleus Heterogeneity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"In Vitro Modeling of the Human Coeruleus to Investigate Selective Regional Vulnerability in Neurodegenerative Disorders"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Catecholamine Signaling in Naturalistic Behaviors
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
"Neuronal Mechanisms Underlying Social Approach and Avoidance Behavior"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
"Changing Neural Activity During Social Dominance and Defeat"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
"Interoceptive and Cognitive Threats Recruit A2 Noradrenergic Signaling Pathways to the Hypothalamus and Limbic Forebrain"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Visualizing the Longitudinal Development of Stress-Induced Anhedonia From Representations of Valence in the PFC"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Diversity of Catecholamine Encoding of Learned Behaviors
9:00 am - 9:20 am
"Dopamine and Causal Learning"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Neural Circuitry of Information Seeking"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
"Dopaminergic Mechanisms That Permit Compulsive Expression of Reward Seeking"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
"Differential activation of VTA ensembles by distinct inputs"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
"Dopamine and the Imagination of Future Rewards"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Low-Dimensional Representations of Associative Fear Learning in the Nucleus Accumbens"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Catecholamines in Actions, Reinforcement, and Decision-Making
6:00 pm - 6:20 pm
"Nucleus Accumbens Contributions to the Reinforcing Effects of Opioids"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
"Striatal Acetylcholine Reports Distinct Update Signals During Flexible Multi-Step Decision Making"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
"Dopamine System Dynamics and Plasticity in Behavioral State Transitions"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
"Optical Interrogation of Dopamine Receptor Signaling in Amygdala During Learning"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
The Role of Catecholamines in Pain and Addiction
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
"Therapeutic Potential of Muscarinic M5 Receptors for Treating Neuropsychiatric Disorders: Focus on M5 Regulation of Dopamine Transmission"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
"Cellular Adaptations in VTA Dopamine Neurons in Experimental Models of Chronic Pain"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
"Activity-Dependent Constraints on Locus Coeruleus Norepinephrine Signaling"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
"Dissociable Control of Motivation and Goal-Directed Behavior by Distinct Ventral Striatal Dopamine Receptors"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
"Estradiol Protects Against Pain-Facilitated Fentanyl Use Via Suppression of Opioid-Evoked Dopamine Activity"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Early-Career Investigator Presentations
6:00 pm - 6:15 pm
"Myelin Plasticity in Ventral Tegmental Area is Required for Opioid Reward"
6:15 pm - 6:20 pm
Discussion
6:20 pm - 6:35 pm
"Striatal Integration of Inverse Dopamine and Serotonin Signals Gates Learning"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
"Local Neuropeptide Y Control of the Locus Coeruleus Noradrenergic System Modulates Anxiety"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
"Investigating Cue Stability and Cognitive Flexibility in the Prefrontal Cortex During Pavlovian Reward Learning"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
"Nicotine In Adolescence Freezes Dopamine Circuits in an Immature State"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
"Resolving Prefrontal Cortical Activity Dynamics and Noradrenergic Modulation of Relapse to Opioid Seeking"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure