Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Catecholaminergic Signaling During Behavior
Discussion Leader: Paul Phillips (University of Washington, United States)
7:40 pm - 8:20 pm
Carmen Sandi (Brain Mind Institute, EPFL, Switzerland)
"Mechanistic Insights into the Vulnerability of the Nucleus Accumbens in Anxiety"
8:20 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Naoshige Uchida (Harvard University, United States)
"What Are "States" in Reinforcement Learning?"
9:15 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Molecular Genetics and Epigenetics of Catecholamine Neurons
Discussion Leader: Zoe McElligott (University of North Carolina at Chapel Hill, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Ian Maze (Howard Hughes Medical Institute at the Icahn School of Medicine at Mount Sinai, United States)
"Protein Catecholaminylation in the Brain: Non-Canonical Roles for Dopamine in the Regulation of Neural Transcriptional Plasticity"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Jeremy Day (University of Alabama at Birmingham, United States)
"Dopamine-Dependent Transcriptional and Chromatin Dynamics in Brain Reward Circuits: Cause and Consequence"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Catherine Pena (Princeton University, United States)
"Dynamic Consequences of Stress on VTA Development"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
Keri Martinowich (Lieber Institute for Brain Development, United States)
"Cell Type-Specific and Spatially-Resolved Transcriptomic Signatures in the Human Locus Coeruleus"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Megan Fox (Penn State College of Medicine, United States)
"Transcriptional Consequences of Fentanyl use in the Ventral Tegmental Area"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizer: Susan Ferguson (University of Washington, United States)
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Molecular Pharmacology and Signaling in Catecholamine Systems
Discussion Leader: Erin Calipari (Vanderbilt University, United States)
6:00 pm - 6:20 pm
Michelle Mazei-Robison (Michigan State University, United States)
"Morphine-Induced Increase in Neuropeptide Expression in Ventral Tegmental Area Dopaminergic Neurons"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Barbara Juarez (University of Maryland, Baltimore, United States)
"Ion Channel Regulation of Dopaminergic Neurophysiology and Behavior"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Jones Parker (Northwestern University, United States)
"Advancing Neurotherapeutics With In Vivo Neural Imaging"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Lillian Brady (The University of Alabama at Birmingham, United States)
"Sex-Specific Regulation of Dopamine Release Mechanisms through Nicotinic Acetylcholine Receptors"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
New Tools to Probe Catecholaminergic Functions
Discussion Leader: Stephan Lammel (University of California, Berkeley, United States)
9:00 am - 9:20 am
Tommaso Patriarchi (University of Zurich, Switzerland)
"A New Family of Genetically Encoded Catecholamines Probes"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Yao Chen (Washington Univeristy in St. Louis School of Medicine, United States)
"Visualizing and Perturbing Neuromodulator Signaling in Real Time"
9:50 am - 10:00 am
Discussion
10:00 am - 10:20 am
Abraham Beyene (Janelia Research Campus, United States)
"Optical Nanosensors for Visualizing Dopamine Dynamics at the Resolution of a Single Bouton"
10:20 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:20 am
Michael Tadross (Duke University, United States)
"Manipulating the Catecholamine Connectome with DART"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Lindsay Schwarz (St. Jude Children's Research Hospital, United States)
"Development of a Novel AAV Intersectional Strategy and it's Application Towards Exploring Locus Coeruleus Heterogeneity"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Fikri Birey (Emory University, United States)
"In Vitro Modeling of the Human Coeruleus to Investigate Selective Regional Vulnerability in Neurodegenerative Disorders"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Catecholamine Signaling in Naturalistic Behaviors
Discussion Leader: Michael Krashes (National Institutes of Health, United States)
6:00 pm - 6:10 pm
Introduction by Discussion Leader
6:10 pm - 6:30 pm
Camilla Bellone (University of Geneva, Switzerland)
"Neuronal Mechanisms Underlying Social Approach and Avoidance Behavior"
6:30 pm - 6:40 pm
Discussion
6:40 pm - 7:00 pm
Annegret Falkner (Princeton University, United States)
"Changing Neural Activity During Social Dominance and Defeat"
7:00 pm - 7:10 pm
Discussion
7:10 pm - 7:30 pm
Linda Rinaman (Florida State Univ., Dept. of Psychology, United States)
"Interoceptive and Cognitive Threats Recruit A2 Noradrenergic Signaling Pathways to the Hypothalamus and Limbic Forebrain"
7:30 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Austin Coley (The Salk Institute for Biological Studies, United States)
"Visualizing the Longitudinal Development of Stress-Induced Anhedonia From Representations of Valence in the PFC"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Diversity of Catecholamine Encoding of Learned Behaviors
Discussion Leader: Christian Lüscher (University of Geneva, Switzerland)
9:00 am - 9:20 am
Vijay Mohan K Namboodiri (UCSF, United States)
"Dopamine and Causal Learning"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Ethan Bromberg-Martin (Washington University School of Medicine, United States)
"Neural Circuitry of Information Seeking"
9:50 am - 10:00 am
Discussion
10:00 am - 10:30 am
Coffee Break
10:30 am - 10:50 am
Kristijan Jovanoski (University of Oxford, United Kingdom)
"Dopaminergic Mechanisms That Permit Compulsive Expression of Reward Seeking"
10:50 am - 11:00 am
Discussion
11:00 am - 11:20 am
Marta Soden (University of Washington, United States)
"Differential activation of VTA ensembles by distinct inputs"
11:20 am - 11:30 am
Discussion
11:30 am - 11:50 am
Josh Berke (University of California, San Francisco, United States)
"Dopamine and the Imagination of Future Rewards"
11:50 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Edward Nieh (University of Virginia, United States)
"Low-Dimensional Representations of Associative Fear Learning in the Nucleus Accumbens"
12:20 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Catecholamines in Actions, Reinforcement, and Decision-Making
Discussion Leader: David Weinshenker (Emory University School of Medicine, United States)
6:00 pm - 6:20 pm
Susan Ferguson (University of Washington, United States)
"Nucleus Accumbens Contributions to the Reinforcing Effects of Opioids"
6:20 pm - 6:30 pm
Discussion
6:30 pm - 6:50 pm
Lauren Burgeno (University of Oxford, United Kingdom)
"Striatal Acetylcholine Reports Distinct Update Signals During Flexible Multi-Step Decision Making"
6:50 pm - 7:00 pm
Discussion
7:00 pm - 7:20 pm
Yevgenia Kozorovitskiy (Northwestern University, United States)
"Dopamine System Dynamics and Plasticity in Behavioral State Transitions"
7:20 pm - 7:30 pm
Discussion
7:30 pm - 7:50 pm
Andrew Lutas (NIDDK/NIH, United States)
"Optical Interrogation of Dopamine Receptor Signaling in Amygdala During Learning"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
The Role of Catecholamines in Pain and Addiction
Discussion Leader: Michael Bruchas (University of Washington, United States)
9:00 am - 9:10 am
Introduction by Discussion Leader
9:10 am - 9:30 am
Julia Lemos (University of Minnesota, United States)
"Therapeutic Potential of Muscarinic M5 Receptors for Treating Neuropsychiatric Disorders: Focus on M5 Regulation of Dopamine Transmission"
9:30 am - 9:40 am
Discussion
9:40 am - 10:00 am
Meaghan Creed (Washington University School of Medicine, United States)
"Cellular Adaptations in VTA Dopamine Neurons in Experimental Models of Chronic Pain"
10:00 am - 10:10 am
Discussion
10:10 am - 10:40 am
Coffee Break
10:40 am - 11:00 am
Li Li (University of Washington, United States)
"Activity-Dependent Constraints on Locus Coeruleus Norepinephrine Signaling"
11:00 am - 11:10 am
Discussion
11:10 am - 11:30 am
Hugo Tejeda (National Institute of Mental Health, United States)
"Dissociable Control of Motivation and Goal-Directed Behavior by Distinct Ventral Striatal Dopamine Receptors"
11:30 am - 11:40 am
Discussion
11:40 am - 12:00 pm
Jessica Higginbotham (Washington University, United States)
"Estradiol Protects Against Pain-Facilitated Fentanyl Use Via Suppression of Opioid-Evoked Dopamine Activity"
12:00 pm - 12:10 pm
Discussion
12:10 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:30 pm
Free Time
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 8:00 pm
Early-Career Investigator Presentations
Discussion Leader: Larry Zweifel (University of Washington, United States)
6:00 pm - 6:15 pm
Belgin Yalcin (Stanford University, United States)
"Myelin Plasticity in Ventral Tegmental Area is Required for Opioid Reward"
6:15 pm - 6:20 pm
Discussion
6:20 pm - 6:35 pm
Daniel Cardozo Pinto (Stanford University, United States)
"Striatal Integration of Inverse Dopamine and Serotonin Signals Gates Learning"
6:35 pm - 6:40 pm
Discussion
6:40 pm - 6:55 pm
Danai Riga (Utrecht University Medical Center, The Netherlands)
"Local Neuropeptide Y Control of the Locus Coeruleus Noradrenergic System Modulates Anxiety"
6:55 pm - 7:00 pm
Discussion
7:00 pm - 7:15 pm
Madelyn Hjort (University of Washington, United States)
"Investigating Cue Stability and Cognitive Flexibility in the Prefrontal Cortex During Pavlovian Reward Learning"
7:15 pm - 7:20 pm
Discussion
7:20 pm - 7:35 pm
Lauren Reynolds (CNRS - ESPCI Paris, France)
"Nicotine In Adolescence Freezes Dopamine Circuits in an Immature State"
7:35 pm - 7:40 pm
Discussion
7:40 pm - 7:55 pm
Elizabeth Doncheck (Medical University of South Carolina, United States)
"Resolving Prefrontal Cortical Activity Dynamics and Noradrenergic Modulation of Relapse to Opioid Seeking"
7:55 pm - 8:00 pm
Discussion
8:00 pm - 9:00 pm
Dinner
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure