SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | KEYNOTE OPENING SESSION |
| Discussion Leader: Ronald Tjalkens (Colorado State University) |
7:40 pm - 7:50 pm | Linda Birnbaum (NIEHS/NIH)
"Opening Address: Advancing the Science of Environmental Health" |
7:50 pm - 8:00 pm | Discussion |
8:00 pm - 8:45 pm | Michael Karin (UCSD)
"Inflammation and Obesity Interplay in Liver Carcinogenesis" |
8:45 pm - 9:15 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:00 am | ADAPTIVE AND COMPENSATORY RESPONSES TO LIVER INJURY |
| Discussion Leader: Jose Manautou (University of Connecticut) |
9:00 am - 9:35 am | Yanan Tian (Texas A&M)
"Novel Mechanism in Transcriptional and Translational Regulation of Xenobiotic Receptors" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Dennis Petersen (Colorado State University)
"Proteomic studies of ethanol-induced liver injury: The unveiling of adaptive and protective responses" |
10:20 am - 10:30 am | Discussion |
10:30 am | Group Photo / Coffee Break |
11:00 am - 12:30 pm | SHORT PRESENTATIONS SESSION |
11:00 am - 11:20 am | Jason Richardson (EOHSI) "Developmental Pyrethroid Exposure Reproduces Features of Attention-Deficit Hyperactivity Disorder: Role of Epigenetic Alterations in the Dopamine System" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:45 am | Jim Luyendyk (University of Kansas Medical Center)
"Xenobiotic-induced biliary inflammation and fibrosis; role of tissue factor and coagulation cascade" |
11:45 am - 11:50 am | Discussion |
11:50 am - 12:10 pm | Brent Carter (Carver College of Medicine, Iowa) "Lung inflammation and fibrosis by asbestos exposure: TNF-alpha MAP kinase and Rac1 signaling" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session 1 |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | EPIGENOMICS |
| Discussion Leader: Dana Dolinoy (University of Michigan) |
7:30 pm - 8:00 pm | David Williams (Oregan State University)
"The Importance of In Utero Versus Lactational Exposure in Lymphoma and Lung Cancer" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Dana Dolinoy (University of Michigan) "Bisphenol A Epigenomics from Mice to Men" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Shuk-mei Ho (University of Cincinnati)
"Epigenetic Memories: How Do They Interact with Life Span Events?" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:00 am | NEW EXPERIMENTAL MODELS IN TOXICOLOGY |
| Discussion Leader: Ron Hines (Medical College of Wisconsin) |
9:00 am - 9:35 am | Jon Essex (University of Southampton)
"Computational Chemistry and Toxicology" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Aaron Bowman (Vanderbilt University Medical Centre)
"Patient derived stem cells as a translation model of toxicological risk" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 12:30 pm | SELECTED LATE BREAKING ABSTRACTS |
11:00 am - 11:15 am | Rhiannon Hardwick (University of Arizona) "Molecular Mechanism of Altered Ezetimibe Disposition in Non-Alcoholic Steatohepatitis" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Tod Harper (University of Texas Medical Branch) "Novel Insights Into Normal AhR Biology" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Michele La Merrill (Mount Sinai School of Medicine) "Influence of 2,2',4,4'-tetrabromodiphenyl ether (BDE47) on metabolic syndrome and insulin resistance in aging mice fed high fat diet" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Theodore Rasmussen (University of Connecticut) "A platform for production and use of hepatocyte-like cells derived from human ES cells and iPS cells." |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session 1 (continued) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | COMPUTATIONAL TOXICOLOGY: EVIDENCE BASED TOXICOLOGY FOR THE 21ST CENTURY |
| Discussion Leader: Dan Petersen (US EPA) |
7:30 pm - 8:00 pm | Rusty Thomas (The Hamner Institute)
"Case Studies in the Application on in vitro toxicity pathways to in vivo modes of action" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Robert Kavlock (US EPA)
"Toxcast: Predictive Signatures for reproductive and developmental toxicity outcomes" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Richard Judson (US EPA)
"The evolution of the endocrine disruptor screening program through the use of high-throughput screening assays and in silico models" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:00 am | CIRCADIAN RHYTHYMS IN TOXICOLOGY: THE CLOCK ALSO MAKES THE POISON |
| Discussion Leader: Helmut Zarble (Rutgers) |
9:00 am - 9:35 am | Kristin Eckel-Mahan (UCI, Department of Pharmacology)
"Circadian Oscillations in the Hepatic Metabolome Implicate the Clock in Liver Physiology and Toxicity" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Marina Antoch (Roswell Park Cancer Institute, New York)
"Circadian rhythyms in toxicology" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 12:30 pm | SELECTED LATE BREAKING ABSTRACTS |
11:00 am - 11:15 am | Patrick Allard (Harvard Medical School) "An integrated system to examine environmental effects on reproductive health" |
11:15 am - 11:20 am | Discussion |
11:20 am - 11:35 am | Charlene Andraos (National Institute for Occupational Health) "In vitro toxicity assessment of dust emissions from six South African gold mine tailing sites" |
11:35 am - 11:40 am | Discussion |
11:40 am - 11:55 am | Louisa Hooven (Oregon State University) "Sublethal Effects of Pesticides on Circadian Behavior in Honeybees" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:15 pm | Quan Lu (Harvard School of Public Health) "Functional genome-wide RNAi screens identify new mechanisms underlying arsenic-induced ER stress and toxicity" |
12:15 pm - 12:20 pm | Discussion |
12:20 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session 2 |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | PHARMACOGENETICS AND PHARMACOGENOMIC OF ADVERSE DRUG REACTIONS |
| Discussion Leader: James Stevens (Eli Lilly and Company) |
7:30 pm - 8:00 pm | Munir Pirmohamed (University of Liverpool)
"Genetic determinants of idiosyncratic drug reactions" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Ivan Rusyn (University of North Carolina)
"Functional genomic and systems biology approaches to understanding drug toxicity" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Ahmed Enayetallah (Pfizer, Groton)
"Use of genetics and genomics in drug safety screening" |
9:10 pm - 9:20 pm | Discussion |
9:20 pm - 9:30 pm | General Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 11:45 am | NEUROINFLAMMATION: CELLULAR AND MOLECULAR MECHANISMS |
| Discussion Leader: Ronald Tjalkens (Colorado State University) |
9:00 am - 9:35 am | Tomás Guilarte (Columbia University)
"Imaging glial activation in vivo" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | G. Jean Harry (NIEHS)
"Microglia heterogeneity: What can it tell us about neuroinflammation and neurotoxicity?" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | Miki Aschner (Vanderbilt)
"Manganese-induced glutamate transporter impairment in astrocytes is reversed by estrogen" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:30 pm | SELECTED LATE BREAKING ABSTRACTS |
11:45 am - 12:00 pm | Julia Bornhorst (University of Muenster) "Low exposure relevant manganese concentrations strongly affect the blood-CSF barrier as well as the DNA damage response in human astrocytes" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Jason Cannon (University of Pittsburgh) "Transgenic rats expressing Parkinson's disease genes: characterization and toxicant sensitivity" |
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:30 pm | Free Time |
4:30 pm - 6:00 pm | Poster Session 2 (continued) |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | KEYNOTE LECTURE |
| Discussion Leader: Michael Aschner (Vanderbilt) |
7:30 pm - 8:30 pm | J. Timothy Greenamyre (Pittsburgh Institute for Neurodegenerative Diseases)
"'The Creature from the Black Lagoon', Parkinson's disease and pesticide toxicity" |
8:30 pm - 9:00 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |