SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session |
| Discussion Leader: Charlene McQueen (USEPA) |
7:40 pm - 8:25 pm | Martin Philbert (University of Michigan)
"The Nanoness of Nanotechnology: What Makes Nano Toxic" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Kenneth Ramos (University of Louisville)
"Reorganization of the Genome by Toxic Injury: A Story of LINES" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Genetic Susceptibility in Toxicology: Am I the 1 in 1,000? |
| Discussion Leader: Ruth Roberts (AstraZeneca) |
9:00 am - 9:35 am | Hans Ketelslegers (ExxonMobil Biomedical Sciences, Belgium)
"Genetic Susceptibility and Environmental Carcinogenesis" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Ann Daly (Newcastle University)
"Identification of Genes Predicting Drug Toxicity and Response in the Parent Genome" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | Judit Marsillach (University of Washington)
"Genetic Susceptibility to Organophosphates and Disease States" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:30 pm | Short Presentation Talks |
| Discussion Leader: Jason Richardson (Robert Wood Johnson Medical School; EOHSI) |
11:45 am - 12:00 pm | Brandon Pierce (University of Chicago)
"Genetic Variation Influences Arsenic Metabolism and Toxicity in Humans"
|
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Aswin Mangerich (University of Konstanz)
"Analysis of Drug- and Toxicant-Dependent Cellular Poly(ADP-ribosyl)ation Dynamics"
|
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Horizons in Toxicology |
| Discussion Leader: John Richburg (University of Texas at Austin) |
7:30 pm - 8:00 pm | Tom Van de Wiele (Ghent University, Belgium)
"Interplay of the Human Gut Microbiome with Xenobiotic Bioavailability and Toxicity" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Shawn Bratton (MD Anderson Cancer Center)
"Regulation of Ubiquitination and Protein Degradation by Caspases" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:30 pm | Short Presentation Talks |
| Discussion Leader: Jason Richardson (Robert Wood Johnson Medical School; EOHSI) |
8:50 pm - 9:05 pm | David Leong (National University of Singapore)
"Endothelial Cell Toxicity from Nanomaterials: Mechanism and Implications"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Laura Kubik (University of Michigan)
"1,3-Dinitrobenzene Induces Age-Specific and Region-Specific Oxidation to Mitochondria-Related Proteins in Rat Brain"
|
9:25 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Advances in Stem Cell: Their Utility in Investigative Environmental Toxicology and Xenobiotic Metabolism |
| Discussion Leader: Theodore Rasmussen (University of Connecticut) |
9:00 am - 9:35 am | Hu Guang (National Institute of Environmental Health Sciences)
"Understanding embryonic Stem Cell Self-Renewal and Differentiation: From Developmental Biology to Environmental Health Sciences" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Mark Mercola (Sanford-Burnham Medical Research Institute)
"Kinetic Imagining Cytometry of Human Stem Cell Derived Cardiomyocytes for Safety Pharmacology and Drug Discovery" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 12:30 pm | Selected Late Breaking Abstracts |
| Discussion Leaders: Patrick Allard (UCLA) and Lauren Aleksunes (Rutgers University; EOHSI) |
11:00 am - 11:25 am | Qin Wang (University of Cincinnati)
"Activation of the Aryl Hydrocarbon Receptor by Dioxin during Embryonic Stem Cell Differentiation Disrupts the Expression of Homeobox Transcription Factors that Control Cardiomyogenesis"
|
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Erik Danen (Leiden University)
"Systems Biology Approach to Delineate Genotoxic Stress Response Signaling Networks"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Qiang Wu (Shanghai Jiao Tong University)
"Zebrafish Phase II Drug-metabolizing UGT Enzymes for Toxicity Studies"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Epigenetic Mechanisms of Transcriptional and Translational Regulation of Gene Expression by Xenobiotic Receptors |
| Discussion Leader: Yanan Tian (Texas A&M University) |
7:30 pm - 8:00 pm | Ronald Hines (USEPA)
"Molecular Mechanisms Regulating Drug and Toxicant Metabolizing Enzyme Ontogeny" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Ann-Bin Shyu (The University of Texas Medical School - Houston)
"Roles of Intrinsically Disordered Proteins in Controlling Mammalian mRNA Turnover" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Xiaobo Zhong (University of Connecticut)
"Chromatin interactions, epigenomics, and transcriptional response to drug induction" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | miRNA as Circulating and Mechanism-Based Biomarkers of Disease |
| Discussion Leader: Jim Stevens (Elli Lilly and Company) |
9:00 am - 9:35 am | Chris Goldring (University of Liverpool, UK)
"Circulating miRNA and Biomarkers of Drug-Induced Liver Injury" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Scot Matkovich (Washington University School of Medicine)
"microRNA Regulation and Signaling in Cardiac Disease" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 12:30 pm | Selected Late Breaking Abstracts |
| Discussion Leaders: Patrick Allard (UCLA) and Lauren Aleksunes (Rutgers University; EOHSI) |
11:00 am - 11:25 am | Natasa Zamurovic (Novartis Institutes for Biomedical Research)
"Identification of Off-Target Binding Proteins by Chemical Proteomics to Elucidate Mechanisms of Toxicity"
|
11:25 am - 11:30 am | Discussion |
11:30 am - 11:55 am | Vishal Vaidya (Harvard Medical School)
"Non-Invasive Micro-Markers in Kidney Disease"
|
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:25 pm | Ashley Green (Rutgers University)
"Epigenetic Regulation of the Dopamine Transporter Following in Vitro Histone Deacetylase Inhibitor Treatment"
|
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Epigenomics at the Intersection of Toxicity and Disease |
| Discussion Leader: Dana Dolinoy (University of Michigan) |
7:30 pm - 8:00 pm | Jay Goodman (Michigan State University)
"An integrated View of Epigenetics: Implications for Safety Assessment" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Trevor Archer (National Institute of Environmental Health Sciences)
"Chromatin Remodeling Proteins in Transcription and Development" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Folami Y. Ideraabdullah (University of North Carolina at Chapel Hill)
"Epigenetic response to endocrine disrupting chemicals, a genetic approach" |
9:20 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Nuclear Factor (Erythroid-derived 2) - Like 2 (Nrf2): Is it all Good? |
| Discussion Leader: Bhagavatula Moorthy (Baylor College of Medicine) |
9:00 am - 9:35 am | Donna Zhang (University of Arizona)
"The regulation of Nrf2 and its dual role in cancer"
|
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | David Tuveson (Cold Spring Harbor)
"Nrf2 Promotes Pancreatic Cancer" |
10:20 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:35 am | Thomas Kensler (University of Pittsburgh)
"Targeting Nrf2 for Disease Prevention" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:30 pm | Selected Late Breaking Abstracts |
| Discussion Leaders: Patrick Allard (UCLA) and Lauren Aleksunes (Rutgers University; EOHSI) |
11:45 am - 12:00 pm | Joel Meyer (Duke University)
"Fate and Consequences of Persistent Mitochondrial DNA Damage"
|
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Elzbieta Janda (University Magna Graecia)
"Prolonged Oxidative Stress Inhibits Basal Autophagy while Inducing Pro-Autophagic Signals in Astroglial Cells: Role of Quinone Oxidoreductase 2"
|
12:20 pm - 12:25 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 8:50 pm | Mitochondrial Diseases |
| Discussion Leader: Alvaro Puga (University of Cincinnati) |
7:30 pm - 8:00 pm | Gary Fiskum (University of Maryland)
"Mitochondrial Mechanism of Toxicity and Cytoprotection" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Ruben Dagda (University of Nevada School of Medicine)
"Regulation of Mitophagy by Serine/Theronine Kinases and Cardiolipin at the Outer Mitochondrial Membrane: Implications for Mitochondrial Diseases" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:30 pm | Keynote Lecture |
| Discussion Leader: Ivan Rusyn (University of North Carolina at Chapel Hill) |
8:50 pm - 9:20 pm | Leona Samson (Massachusetts Institute of Technology)
"Inter-individual Variations in DNA Repair" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |