Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: Mechanistic and Personalized Approaches to Evaluating Toxicity and the Microbiome |
| Discussion Leader: Charlene McQueen (U.S. Environmental Protection Agency, USA) |
7:40 pm - 8:25 pm | Nathan Price (Institute for Systems Biology, USA) "Predicting and Preventing Disease: Lessons from the 100K Wellness Project" |
8:25 pm - 8:35 pm | Discussion |
8:35 pm - 9:20 pm | Rob Knight (University of California, San Diego, USA) "Evaluating Toxicity and the Microbiome" |
9:20 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | What’s in Your Toolbox: Emerging Technologies for
Mechanistic Toxicology / Late Breaking Talks |
| Discussion Leaders: John Richburg (The University of Texas at Austin, USA) and Shaun McCullough (U.S. Environmental Protection Agency, USA) |
9:00 am - 9:35 am | Joanna Burdette (University of Illinois at Chicago, USA) "Integrating Primary Culture of Human Reproductive Organs as a Preclinical Model Using Microfluidics" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Robert Chapin (Pfizer Drug Safety, USA) "Neonatal Mouse Testis Explants as a Phenotypic Screen for Testicular Toxicity" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:35 am | Serrine Lau (University of Arizona, USA) "Glyco-Oxidative Protein Modification in Type 2 Diabetes: Mass Spectrometry Based Biomarker Discovery and Novel Therapeutic Mechanism of Metformin" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:05 pm | Selected from Poster Abstracts: Theodore Rasmussen (University of Connecticut, USA) "Using Human Stem Cells for Personalized Cellular Medicine, Pharmacology, and Teratology" |
12:05 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Selected from Poster Abstracts: Chia-I Ko (University of Cincinnati, USA) "Oscillating Expression of Environmental Sensor Receptor in Mouse Embryonic Stem Cells Deregulates Mitotic Progression and Causes Pluripotency Loss" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Computational Models in Toxicology |
| Discussion Leader: Ronald Hines (U.S. Environmental Protection Agency, USA) |
7:30 pm - 8:00 pm | Nisha Sipes (National Institute of Environmental Health Sciences, NIH, USA) "Computational Models
for Exposure and Dosimetry" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Thomas Knudsen (U.S. Environmental Protection Agency, USA) "Analyzing Cellular Network Responses in Developmental Toxicity Utilizing Predictive Modeling and Computer Simulation" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Rudy Richardson (University of Michigan, USA) "Insights into Toxicant-Protein Interactions Using Docking, Inverse Docking, and Molecular Dynamics Simulations" |
9:20 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Incorporating the Inflammasome into Mechanistic Toxicology
Research / Late Breaking Talks |
| Discussion Leaders: Jose Manautou (University of Connecticut, USA) and Lisa Chadwick (National Institute of Environmental Health Sciences, NIH, USA) |
9:00 am - 9:35 am | Arti Shukla (University of Vermont, USA) "Role of Inflammasomes in Mesothelial to Fibroblastic Transition (MFT)" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Julie Castaneda (University of California, Los Angeles, USA) "Role of Differential CB2 Expression Patterns in the Biologic Function of B Cells" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Selected from Poster Abstracts: Tracie Baker (University of Wisconsin-Madison, USA) "Zebrafish as a Model for Adult-Onset and Transgenerational Male Infertility Due to TCDD Exposure" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:40 am | Selected from Poster Abstracts: Bradley Baumgarner (University of South Carolina Upstate, USA) "Caffeine Significantly Reduces Mitochondrial Respiration and Increases Caspase-Dependent Cell Death in Murine Skeletal Muscle Cells" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Selected from Poster Abstracts: Nishad Jayasundara (Duke University, USA) "Aryl Hydrocarbon Receptor Dependent Mitochondrial Toxicity of Simple and Complex PAH Mixtures - Assessing Early Life Exposure and Later Life Consequences" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Maria Jaime (National Institute of Diabetes and Digestive and Kidney Diseases, NIH, USA) "High Throughput Screening System for Drosophila" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Elizabeth Marchlewicz (University of Michigan School of Public Health, USA) "Prenatal Diet and Bisphenol A Exposure Impact Offspring Oxidative Stress and Hepatic Steatosis" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | What’s in Your Toolbox: Novel In Vivo Model Systems in Mechanistic Toxicology |
| Discussion Leader: Patrick Allard (University of California, Los Angeles, USA) |
7:30 pm - 8:00 pm | Alicia Timme-Laragy (University of Massachusetts Amherst, USA) "Molecular Evolution of the Nrf2 Transcription Factor in Zebrafish: Implications for Toxicology" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Jyotshna Kanungo (National Center for Toxicological Research, Food and Drug Administration, USA) "Zebrafish in Drug Safety Assessment: Phenotype-Based Mechanistic Studies" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Chris Vulpe (University of Florida, Gainesville, USA) "Functional Profiling to Identify Adverse Outcome Pathways in Eukaryotes" |
9:20 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Systems Pharmacology Approaches to
Mechanisms of Drug Efficacy and Toxicity / Late Breaking Talks |
| Discussion Leaders: Donna Mendrick (U.S. Food and Drug Administration, USA) and Angela Slitt (University of Rhode Island, USA) |
9:00 am - 9:35 am | Weida Tong (National Center for Toxicological Research, Food and Drug Administration, USA) "Liver Toxicity Knowledge Base: A Systems Approach to a Complex Endpoint" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | James Stevens (Eli Lilly & Company, USA) "Reading the Toxicogenomic MAP (TXG-MAP): Modular Gene Expression Changes Associated with Pathogenesis" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:20 am | Selected from Poster Abstracts: Ruth Roberts (Apconix, United Kingdom) "Predicting Human Responses to Drugs: Challenges and Opportunities of In Vitro Approaches" |
11:20 am - 11:25 am | Discussion |
11:25 am - 11:40 am | Selected from Poster Abstracts: Peter Loskill (University of California, Berkeley, USA) "Organs-on-a-Chip – Microphysiological Platforms as In Vitro Models of Cardiac and Adipose Tissue" |
11:40 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Selected from Poster Abstracts: James Heslop (University of Liverpool, United Kingdom) "Isogenic Comparison of Hepatocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells Derived from Primary Human Hepatocytes and Dermal Fibroblasts" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Suzanne Martos (Johns Hopkins Bloomberg School of Public Health, USA) "Whole-Genome Bisulfite Sequencing Reveals Genomic Regions Vulnerable to Epigenetic Perturbation" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Dana Walsh (University of North Carolina at Chapel Hill, USA) "Exposure to Combustion Products Induces Loss of Bacterial Community Diversity and Inhibits Cellular Stress Response" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Generational Considerations in Toxicological
Sciences |
| Discussion Leader: Alvaro Puga (University of Cincinnati, USA) |
7:30 pm - 8:00 pm | Marisa Bartolomei (University of Pennsylvannia, USA) "Multigenerational Effects of Bisphenol A Exposure in a Mouse Model" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Margaret Bell (University of Texas at Austin, USA) "Effects of PCB Exposure on Rat Brain and Behavior: Timing and Life History Matter" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Toshi Shioda (Massachusetts General Hospital / Harvard Medical School, USA) "Epigenetic Basis of Transgenerational Effects: Competing Hypotheses and Research Strategies" |
9:20 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Microphysiological
Systems or Animals? The Present and Future of Safety and Efficacy Testing / Late-Breaking Topics |
| Discussion Leaders: Ruth Roberts (Apconix, United Kingdom) and Carol Shreffler (National Institute of Environmental Health Sciences, NIH, USA) |
9:00 am - 9:35 am | Matthew Wagoner (AstraZeneca Pharmaceuticals, USA) "Integration of Microphysiological Systems into Risk Assessment in the Drug Discovery Setting" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Remi Villenave (Wyss Institute for Biologically Inspired Engineering at Harvard University, USA) "Organs on a Chip: Progress in Microphysiological Systems" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:35 am | Uwe Marx (Technical University of Berlin, Germany) "Potential Impact of Human Multi Organ on Chip Concepts on Drug Safety Assessment" |
11:35 am - 11:45 am | Discussion |
11:45 am - 11:55 am | Selected from Poster Abstracts: Emma Bowers (University of North Carolina at Chapel Hill, USA) "Modeling Ozone Exposure Response Heterogeneity In Vitro: The Intersection of Inter-Individual Variation and Epigenetics" |
11:55 am - 12:00 pm | Discussion |
12:00 pm - 12:10 pm | Selected from Poster Abstracts: Jessica Camacho (University of California, Los Angeles, USA) "Examining Environmental Effects on the Germline Epigenome" |
12:10 pm - 12:15 pm | Discussion |
12:15 pm - 12:25 pm | Selected from Poster Abstracts: Prajakta Shimpi (University of Rhode Island, USA) "Early Epigenetic Modulation of Nrf2 and Lipogenic Genes by PNPP Exposure of Bisphenol A Is Associated with Hepatic Steatosis in Female Mice" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Session: Genetic and Epigenetic Mechanisms of Toxicology / Communicating Science and Risk |
| Discussion Leaders: Yanan Tian (Texas A&M University, USA) and Helmut Zarbl (Rutgers University, USA) |
7:30 pm - 8:00 pm | Quan Lu (Harvard School of Public Health, USA) "Integrative Genomics of Cellular Stress Response and Metal Toxicity" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Richard Paules (National Institute of Environmental Health Services, NIH, USA) "Tox21 Genetic, Genomic, and Epigenetic Efforts to Elucidate Mechanisms of Chemical Toxicities" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Julia Moore (Former Director, Legislative and Public Affairs, National Science Foundation, USA) "Risky Business: Policy, the Media and Public" |
9:20 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |