Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: New Science and New Horizons
in Mechanistic Toxicology
7:40 pm - 8:10 pm
"Toxicogenomics in the Era of Precision Medicine"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
"Daddy Issues: Paternal Effects of Diet and Toxins on the Next Generation"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Xenobiotic
Receptors and Their Novel Functions
9:00 am - 9:30 am
"Ah Receptor Is a Therapeutic Target for Drug-Induced Enteropathy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"CAR Scaffolds GADD45B to Regulate Cell Signaling in HCC Development"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"The Endobiotic Functions of Xenobiotic Receptors"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Attenuation of Polycyclic Aromatic Hydrocarbon (PAH)-Mediated Pulmonary Carcinogenesis in Mice by Omega-3-Fatty Acids: Evidence for Mechanisms Entailing DNA Adducts as Well as Epigenetic Genes"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Molecular Mechanisms of Inter-Individual Variability in the Response to Toxic Exposures"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetic
and Epigenetic Mechanisms of Toxicology
7:30 pm - 8:00 pm
"Chromatin Mechanisms of Epigenetic Control"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Epigenetic Mechanisms of Air Pollution-Induced Immune Dysfunction in Children"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Understanding the Role of Repetitive Elements in Toxicity Responses"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Noncoding
RNA and Their Roles in Regulating Toxic Responses
9:00 am - 9:30 am
"piRNA Targeted DNA Methylation: Implication for Toxicological and Translational Sciences"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"RNA Methylation in Gene Expression Regulation"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Non-Coding RNAs and Metal Carcinogenesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Plasma Viral and Cellular miRNAs as Targeted-Biomarkers of Occult Viral Infections Prevalence and Sepsis Aggressiveness"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"The Functions of lncRNA MALAT1 in Regulating Generation of Reactive Oxygen Species and the Insulin Responses in Mice"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Humanized Models: Where Are We Now?
7:30 pm - 8:00 pm
"Humanized Mouse Models – Success and Limitations"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Cell Replacement Therapies – iPSC or Transdifferentiation"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Translational In Vivo and In Vitro Models in Oncology Drug Development"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tick Tock Goes the Clock: Circadian
Rhythm of Gut Microbiota Influences Host Metabolic and Drug Functions
9:00 am - 9:30 am
"Epithelial Cell Contributions to Intestinal Immunity"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
" Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Central Role of Circadian Rhythm in Cellular Responses to Toxicants and Stressors"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Circadian Regulation of Polyaromatic Hydrocarbon Metabolism in Breast Cancer and Mouse Mammary Gland"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Bisphenol Compound Toxicity: Linking a Behavioral Phenotype to Microbiota Composition"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Non-Animal
Methods in Toxicology: Novel Mechanisms and New Opportunities
7:30 pm - 8:00 pm
"Systems Toxicology: Linking Network Perturbation to Phenotypes"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Taxogenomic Read Across: Predicting Human Toxicity Using Non-Animal Species"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Where Is the Risk? In Vitro -In Vivo Extrapolations (IVIVE) Using Reverse Toxicokinetics"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
System Biological Approaches to Assessing
Xenobiotic Responses
9:00 am - 9:30 am
"An Integrative Data Mining Approach to Identify Adverse Outcome Pathway Signatures"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Increasing Confidence in Read Across Through Big Science"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Evolution of Epigenetic Regulation in Vertebrate Genome"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"US Tox21 Program: Using In Vitro qHTS Methods to Profile Environmental Chemicals"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Percellome Toxicogenomics Project for Mechanism-Based Toxicity Prediction"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Mechanisms of Toxicity – A Path Forward
7:30 pm - 8:05 pm
"Genome-Wide CRISPR Library Screen Identifies a Transcriptional Repressor Complex that Suppresses Cellular ER Stress Response"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:55 pm
" Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure