Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: New Science and New Horizons
in Mechanistic Toxicology
Discussion Leader: Yanan Tian (Texas A&M University, USA)
7:40 pm - 8:10 pm
Kenneth Ramos (University of Arizona Health Sciences, USA)
"Toxicogenomics in the Era of Precision Medicine"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 8:55 pm
Oliver Rando (University of Massachusetts Medical School, USA)
"Daddy Issues: Paternal Effects of Diet and Toxins on the Next Generation"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Xenobiotic
Receptors and Their Novel Functions
Discussion Leader: Michael Gallo (Robert Wood Johnson Medical School, Rutgers University, USA)
9:00 am - 9:30 am
Gary Perdew (Pennsylvania State University, USA)
"Ah Receptor Is a Therapeutic Target for Drug-Induced Enteropathy"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Masahiko Negishi (National Institute of Environmental Health Sciences, NIH, USA)
"CAR Scaffolds GADD45B to Regulate Cell Signaling in HCC Development"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Wen Xie (University of Pittsburgh, USA)
"The Endobiotic Functions of Xenobiotic Receptors"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Bhagavatula Moorthy (Baylor College of Medicine, USA)
"Attenuation of Polycyclic Aromatic Hydrocarbon (PAH)-Mediated Pulmonary Carcinogenesis in Mice by Omega-3-Fatty Acids: Evidence for Mechanisms Entailing DNA Adducts as Well as Epigenetic Genes"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Shaun McCullough (U.S. Environmental Protection Agency, USA)
"Molecular Mechanisms of Inter-Individual Variability in the Response to Toxic Exposures"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
Power Hour
The GRC Power Hour is an optional informal gathering open to all meeting participants. It is designed to help address the challenges women face in science and support the professional growth of women in our communities by providing an open forum for discussion and mentoring.
Organizers: Dana Dolinoy (University of Michigan, USA) and Karilyn Sant (University of Massachusetts, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Genetic
and Epigenetic Mechanisms of Toxicology
Discussion Leaders: Shaun McCullough (U.S. Environmental Protection Agency, USA) and Patrick Allard (University of California, Los Angeles, USA)
7:30 pm - 8:00 pm
Brian Strahl (University of North Carolina at Chapel Hill, USA)
"Chromatin Mechanisms of Epigenetic Control"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Kari Nadeau (Stanford University, USA)
"Epigenetic Mechanisms of Air Pollution-Induced Immune Dysfunction in Children"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Richard Woychik (National Institute of Environmental Health Sciences, NIH, USA)
"Understanding the Role of Repetitive Elements in Toxicity Responses"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Noncoding
RNA and Their Roles in Regulating Toxic Responses
Discussion Leader: Frederick Tyson (National Institute of Environmental Health Sciences, NIH, USA)
9:00 am - 9:30 am
Dana Dolinoy (University of Michigan, USA)
"piRNA Targeted DNA Methylation: Implication for Toxicological and Translational Sciences"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Chuan He (University of Chicago, USA)
"RNA Methylation in Gene Expression Regulation"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Chengfeng Yang (University of Kentucky, USA)
"Non-Coding RNAs and Metal Carcinogenesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Enrique Fuentes-Mattei (University of Texas MD Anderson Cancer Center, USA)
"Plasma Viral and Cellular miRNAs as Targeted-Biomarkers of Occult Viral Infections Prevalence and Sepsis Aggressiveness"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Jingshu Chen (Texas A&M University, USA)
"The Functions of lncRNA MALAT1 in Regulating Generation of Reactive Oxygen Species and the Insulin Responses in Mice"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Humanized Models: Where Are We Now?
Discussion Leader: Heather Wallace (University of Aberdeen, United Kingdom)
7:30 pm - 8:00 pm
Michael Brehm (University of Massachusetts Medical School, USA)
"Humanized Mouse Models – Success and Limitations"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Matthew Wright (Newcastle University , United Kingdom)
"Cell Replacement Therapies – iPSC or Transdifferentiation"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Silvia Guionaud (Drug Safety and Metabolism, AstraZeneca, United Kingdom)
"Translational In Vivo and In Vitro Models in Oncology Drug Development"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Tick Tock Goes the Clock: Circadian
Rhythm of Gut Microbiota Influences Host Metabolic and Drug Functions
Discussion Leaders: Tamara Tal (U.S. Environmental Protection Agency, USA) and Charlene McQueen (University of Arizona, USA)
9:00 am - 9:30 am
Lora Hooper (University of Texas Southwestern Medical Center, USA)
"Epithelial Cell Contributions to Intestinal Immunity"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Vanessa Leone (University of Chicago, USA)
" Effects of Diurnal Variation of Gut Microbes and High-Fat Feeding on Host Circadian Clock Function and Metabolism"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Mingzhu Fang (Rutgers School of Public Health, USA)
"Central Role of Circadian Rhythm in Cellular Responses to Toxicants and Stressors"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Emily Schmitt (Texas A&M University, USA)
"Circadian Regulation of Polyaromatic Hydrocarbon Metabolism in Breast Cancer and Mouse Mammary Gland"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Tara Catron (ORISE, U.S. Environmental Protection Agency, USA)
"Bisphenol Compound Toxicity: Linking a Behavioral Phenotype to Microbiota Composition"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Non-Animal
Methods in Toxicology: Novel Mechanisms and New Opportunities
Discussion Leader: Ruth Roberts (ApconiX, United Kingdom)
7:30 pm - 8:00 pm
Rebecca Clewell (ScitoVation, USA)
"Systems Toxicology: Linking Network Perturbation to Phenotypes"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
John Colbourne (The University of Birmingham, United Kingdom)
"Taxogenomic Read Across: Predicting Human Toxicity Using Non-Animal Species"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Caroline Ring (ToxStrategies, Inc., USA)
"Where Is the Risk? In Vitro -In Vivo Extrapolations (IVIVE) Using Reverse Toxicokinetics"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
System Biological Approaches to Assessing
Xenobiotic Responses
Discussion Leaders: Ronald Hines (U.S. Environmental Protection Agency, USA) and Rhiannon Hardwick (Theravance Biopharma, USA)
9:00 am - 9:30 am
Stephen Edwards (U.S. Environmental Protection Agency, USA)
"An Integrative Data Mining Approach to Identify Adverse Outcome Pathway Signatures"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Craig Rowlands (Underwriters Laboratories, USA)
"Increasing Confidence in Read Across Through Big Science"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Ting Wang (Washington University School of Medicine, USA)
"Evolution of Epigenetic Regulation in Vertebrate Genome"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Menghang Xia (National Center for Advancing Translational Sciences, NIH, USA)
"US Tox21 Program: Using In Vitro qHTS Methods to Profile Environmental Chemicals"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Jun Kanno (Japan Bioassay Research Center, Japan)
"Percellome Toxicogenomics Project for Mechanism-Based Toxicity Prediction"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Mechanisms of Toxicity – A Path Forward
Discussion Leader: Michael Holsapple (Michigan State University, USA)
7:30 pm - 8:05 pm
Quan Lu (Harvard T.H. Chan School of Public Health, USA)
"Genome-Wide CRISPR Library Screen Identifies a Transcriptional Repressor Complex that Suppresses Cellular ER Stress Response"
8:05 pm - 8:20 pm
Discussion
8:20 pm - 8:55 pm
Cheryl Walker (Baylor College of Medicine, USA)
" Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives"
8:55 pm - 9:10 pm
Discussion
9:10 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure