Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Exposome: A Framework for Toxicology at a Grand Scale
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
"Using the Exposome to Study Adverse Events at a Population Level"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
"Analytics for Interrogating Exposomes and Phenomes in Disease and Health"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Diverse Tissues, Diverse Responses: Delving into Organ Toxicity
9:00 am - 9:30 am
"Evaluating Diet-PFAS Interactions in Models of Obesity and NAFLD"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Environmental PPARγ and RXR Ligands: Selective Agonists that Disrupt Bone and Adipose Homeostasis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Flavoring Chemicals and Pulmonary Cellular Toxicological Responses"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Evaluation of the Relative Performance of Pancreas Specific microRNAs in Rat Plasma as Biomarkers of Pancreas Injury"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Evaluation of the Relevance of DILI Predictive Hypotheses in Early Drug Development: Review of In Vitro Methodologies vs BDDCS Classification"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances at the Interface of Toxicology and Medicine: Toward Prevention and Treatment of Toxicant-Mediated Disease
7:30 pm - 8:00 pm
"From the Most Dangerous Dioxin to the Most Profitable Weed Killer: Environmental Risks of Multiple Myeloma"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Mechanisms of Toxicant Associated Steatohepatitis in Translational Studies"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"The Application of Library Screening Technologies to Translational Small Molecule Discovery Investigations"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Nuclear Receptors Old and New: Novel Pharmacological and Toxicological Targets
9:00 am - 9:30 am
"Nuclear Receptors in Drug Discovery"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Targeted Nuclear Receptor Modulation of the Gut-Liver Axis in Xenobiotic Biotransformation"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Hepatocyte Nuclear Factor 4 Alpha: A Novel (and Often Ignored) Toxicant Target"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Epigenome-Based Predictive Modeling of Tissue-Specific Nuclear Receptor Signaling Networks"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Induction of the Antioxidant Response by NRF2 Signaling Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone in Human Lung Cells"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Applications of Microphysiological Systems in Toxicological Research
7:30 pm - 8:00 pm
"Microphysiological Systems, Mechanisms of Action, and Chronotoxicology"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Translational Applications of Tissue Chip Technologies"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Application of Organs on Chips in Pharma Industry: The Need, Gaps and the Vision"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Early-Career Investigator Presentations
9:00 am - 9:30 am
"Aryl Hydrocarbon Receptor: The Good, the Bad and the Toxic"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Environmental Exposures and Stem Cell Reprogramming: Understanding Racial Disparities in Triple Negative Breast Cancer"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Epigenetics and Public Health"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Arsenic Modulates Glucocorticoid Receptor Signaling in Placenta"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"In Vitro Evaluation of Anthracycline-Induced Cardiotoxicity and Mitigation by Perturbation of Angiotensin Signalling"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Testing Beyond Animals: Pushing the Frontiers in Safety Evaluation
7:30 pm - 8:00 pm
"In Vivo 5-Day Transcriptomics Approach to Estimating Points of Departure"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"From Plates to Human: Validating Assays with Investigative Toxicology"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
"Bridging the Gap with RISK21: Risk Assessment in the 21st Century"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Technologies and Alternative Testing Strategies
9:00 am - 9:30 am
"Using 3D Organotypic Cultures to Model Cancer Biology and Treatment Response"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
"Therapeutic Strategies via Genome Engineering: New Approaches and Challenges"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
"Rewiring of the 3D Genome in Inorganic Arsenic-Mediated Carcinogenesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
"Predictive Toxicogenomics Space Modeling Serves Effectively to Sensitive Biomarker-Based Read Across from Capturing Toxic Mode-of-Action of Lowest-Observable Effect Levels"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
"Molecular Basis of the 'Baseline Response' and 'Transient Response' Observed in the Newly Designed Repeated Dose Study: Epigenetic Modifications"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Utilizing Big Data and Quantitative Systems Modeling to Derive Outcomes
7:30 pm - 8:10 pm
"Utilizing Big Data and Systems Modeling to Derive a Widely Applicable Predictive Toxicogenomics Space Tool"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 9:05 pm
"Quantitative Mechanistic High Content Data for Predictive Systems Toxicology Modelling"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure