Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Site Staff / Welcome from the GRC Chair
7:40 pm - 9:30 pm
Keynote Session: The Exposome: A Framework for Toxicology at a Grand Scale
Discussion Leader: Gary Miller (Columbia University, USA)
7:40 pm - 7:50 pm
Introduction by Discussion Leader
7:50 pm - 8:30 pm
Roel Vermeulen (Utrecht University, The Netherlands)
"Using the Exposome to Study Adverse Events at a Population Level"
8:30 pm - 8:40 pm
Discussion
8:40 pm - 9:20 pm
Chirag Patel (Harvard Medical School, USA)
"Analytics for Interrogating Exposomes and Phenomes in Disease and Health"
9:20 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Diverse Tissues, Diverse Responses: Delving into Organ Toxicity
Discussion Leaders: Alicia Timme-Laragy (University of Massachusetts Amherst, USA) and Ronald Hines (U.S. Environmental Protection Agency, USA)
9:00 am - 9:30 am
Angela Slitt (The University of Rhode Island, USA)
"Evaluating Diet-PFAS Interactions in Models of Obesity and NAFLD"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Jennifer Schlezinger (Boston University School of Public Health, USA)
"Environmental PPARγ and RXR Ligands: Selective Agonists that Disrupt Bone and Adipose Homeostasis"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Irfan Rahman (University of Rochester, USA)
"Flavoring Chemicals and Pulmonary Cellular Toxicological Responses"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Selected from Poster Abstracts: Wendy Bailey (Merck & Co., Inc., USA)
"Evaluation of the Relative Performance of Pancreas Specific microRNAs in Rat Plasma as Biomarkers of Pancreas Injury"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Selected from Poster Abstracts: Rosa Chan (Janssen Pharmaceuticals, Inc., USA)
"Evaluation of the Relevance of DILI Predictive Hypotheses in Early Drug Development: Review of In Vitro Methodologies vs BDDCS Classification"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address challenges women face in science and issues of diversity and inclusion. The program supports the professional growth of all members of our communities by providing an open forum for discussion and mentoring.
Organizers: Ruth Roberts (ApconiX, United Kingdom) and Jose Manautou (University of Connecticut, USA)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Advances at the Interface of Toxicology and Medicine: Toward Prevention and Treatment of Toxicant-Mediated Disease
Discussion Leader: Kenneth Ramos (Texas A&M University Health Science Center, USA)
7:30 pm - 8:00 pm
Yong Li (Baylor College of Medicine, USA)
"From the Most Dangerous Dioxin to the Most Profitable Weed Killer: Environmental Risks of Multiple Myeloma"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Matt Cave (University of Louisville School of Medicine, USA)
"Mechanisms of Toxicant Associated Steatohepatitis in Translational Studies"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Clifford Stephan (Texas A&M University, USA)
"The Application of Library Screening Technologies to Translational Small Molecule Discovery Investigations"
9:20 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Nuclear Receptors Old and New: Novel Pharmacological and Toxicological Targets
Discussion Leaders: Kari Sant (San Diego State University, USA) and Heather Wallace (University of Aberdeen, United Kingdom)
9:00 am - 9:30 am
Lois Lehman-McKeeman (Bristol-Myers Squibb, USA)
"Nuclear Receptors in Drug Discovery"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Julia Cui (University of Washington, USA)
"Targeted Nuclear Receptor Modulation of the Gut-Liver Axis in Xenobiotic Biotransformation"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Udayan Apte (University of Kansas Medical Center, USA)
"Hepatocyte Nuclear Factor 4 Alpha: A Novel (and Often Ignored) Toxicant Target"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Selected from Poster Abstracts: Sudin Bhattacharya (Michigan State University, USA)
"Epigenome-Based Predictive Modeling of Tissue-Specific Nuclear Receptor Signaling Networks"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Selected from Poster Abstracts: Jessica Murray (University of Pennsylvania, USA)
"Induction of the Antioxidant Response by NRF2 Signaling Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone in Human Lung Cells"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Applications of Microphysiological Systems in Toxicological Research
Discussion Leader: Peter Loskill (Fraunhofer IGB / University of Tübingen, Germany)
7:30 pm - 8:00 pm
John Wikswo (Vanderbilt University, USA)
"Microphysiological Systems, Mechanisms of Action, and Chronotoxicology"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Murat Cirit (Massachusetts Institute of Technology, USA)
"Translational Applications of Tissue Chip Technologies"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Adrian Roth (F. Hoffmann-La Roche Ltd, Switzerland)
"Application of Organs on Chips in Pharma Industry: The Need, Gaps and the Vision"
9:20 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Early-Career Investigator Presentations
Discussion Leaders: Patrick Allard (University of California, Los Angeles, USA) and Phillip Wages (PepsiCo, USA)
9:00 am - 9:30 am
Daniel Gorelick (Baylor College of Medicine, USA)
"Aryl Hydrocarbon Receptor: The Good, the Bad and the Toxic"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Justin Colacino (University of Michigan School of Public Health, USA)
"Environmental Exposures and Stem Cell Reprogramming: Understanding Racial Disparities in Triple Negative Breast Cancer"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Emma Marczylo (Public Health England, United Kingdom)
"Epigenetics and Public Health"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Cassandra Meakin (University of North Carolina at Chapel Hill, USA)
"Arsenic Modulates Glucocorticoid Receptor Signaling in Placenta"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Kimberly Rockley (ApconiX, United Kingdom)
"In Vitro Evaluation of Anthracycline-Induced Cardiotoxicity and Mitigation by Perturbation of Angiotensin Signalling"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:00 pm - 7:30 pm
Business Meeting
Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair
7:30 pm - 9:30 pm
Testing Beyond Animals: Pushing the Frontiers in Safety Evaluation
Discussion Leaders: Marie Fortin (Jazz Pharmaceuticals, USA) and Jessica LaRocca (Corteva Agriscience, USA)
7:30 pm - 8:00 pm
William Gwinn (National Institute of Environmental Health Sciences, NIH, USA)
"In Vivo 5-Day Transcriptomics Approach to Estimating Points of Departure"
8:00 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
David Allen (Integrated Laboratory Systems, USA)
"From Plates to Human: Validating Assays with Investigative Toxicology"
8:40 pm - 8:50 pm
Discussion
8:50 pm - 9:20 pm
Michelle Embry (Health and Environmental Sciences Institute (HESI), USA)
"Bridging the Gap with RISK21: Risk Assessment in the 21st Century"
9:20 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Emerging Technologies and Alternative Testing Strategies
Discussion Leaders: Shaun McCullough (U.S. Environmental Protection Agency, USA) and Frederick Tyson (National Institute of Environmental Health Sciences, NIH, USA)
9:00 am - 9:30 am
Andrew Ewald (Johns Hopkins University, USA)
"Using 3D Organotypic Cultures to Model Cancer Biology and Treatment Response"
9:30 am - 9:40 am
Discussion
9:40 am - 10:10 am
Prashant Mali (University of California, San Diego, USA)
"Therapeutic Strategies via Genome Engineering: New Approaches and Challenges"
10:10 am - 10:20 am
Discussion
10:20 am - 10:50 am
Coffee Break
10:50 am - 11:20 am
Yvonne Fondufe-Mittendorf (University of Kentucky, USA)
"Rewiring of the 3D Genome in Inorganic Arsenic-Mediated Carcinogenesis"
11:20 am - 11:30 am
Discussion
11:30 am - 11:45 am
Selected from Poster Abstracts: Pekka Kohonen (Karolinska Institutet, Sweden)
"Predictive Toxicogenomics Space Modeling Serves Effectively to Sensitive Biomarker-Based Read Across from Capturing Toxic Mode-of-Action of Lowest-Observable Effect Levels"
11:45 am - 11:55 am
Discussion
11:55 am - 12:10 pm
Selected from Poster Abstracts: Ryuichi Ono (Division of Cellular and Molecular Toxicology, National Institute of Health Sciences (NIHS), Japan)
"Molecular Basis of the 'Baseline Response' and 'Transient Response' Observed in the Newly Designed Repeated Dose Study: Epigenetic Modifications"
12:10 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Utilizing Big Data and Quantitative Systems Modeling to Derive Outcomes
Discussion Leader: Pete Newham (AstraZeneca, United Kingdom)
7:30 pm - 8:10 pm
Roland Grafstrom (Institute of Environmental Medicine, Karolinska Institutet, Sweden)
"Utilizing Big Data and Systems Modeling to Derive a Widely Applicable Predictive Toxicogenomics Space Tool"
8:10 pm - 8:25 pm
Discussion
8:25 pm - 9:05 pm
Bob van de Water (Leiden University, The Netherlands)
"Quantitative Mechanistic High Content Data for Predictive Systems Toxicology Modelling"
9:05 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure