Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Gene Essentiality and Functional Genomics for Mechanistic Toxicology
Discussion Leader: Muireann Coen (AstraZeneca/Imperial College London, United Kingdom)
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:25 pm
James Stevens (Leiden University, United States)
"Modernizing Toxicology to Affect Radical Change: Ideation, Evolution, and Application of New Technologies"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
Keren Carss (AstraZeneca, United Kingdom)
"Large-Scale Human Genetics in Drug Target Discovery and Safety Assessment"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Artificial Intelligence in Toxicology and its Role in Decision Making
Discussion Leader: Ruth Roberts (ApconiX, United Kingdom)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Shraddha Thakkar (Center for Drug Evaluations and Research, Food and Drug Administrations, United States)
"Deep Learning using HTS Transcriptomics to Predict DILI"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Ronald Tjalkens (Colorado State University, United States)
"Integrating Whole-Brain Scanning Microscopy with Artificial Intelligence and Neural Network Analysis for High-Throughput Quantitative Assessment of Neurotoxicity and Neurodegeneration"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
Matthew Martin (Pfizer Inc., United States)
"Drug and Target Safety Modeling Using Big/Complex Data and Machine Learning"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
Samuel Cochran (Ohio State University, United States)
"The Role of Myeloid-Expressed Heme Oxygenase-1 (HO-1) in Ozone-Induced Pulmonary Injury, Antioxidant Responses, and Altered Heme Metabolism"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Marjorie Marin (University of Massachusetts Amherst, United States)
"Exposure to Perfluorooctanesulfonic Acid (PFOS) Increases the Formation of Proinsulin Disulfide-Linked Complexes in Pancreatic BetaTC-6 Cells"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Alessandro Venosa (University of Utah, United States)
"Spatial Investigation of Stress and Inflammation in the Healthy and Susceptible Lung"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hour™
The GRC Power Hour™ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
Organizers: Samantha Snow (ICF, United States) and Sarah Lacher (University of Minnesota Medical School, United States)
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Cellular Microenvironment in Tissue Health, Disease and Toxic Exposure Outcomes
Discussion Leaders: Shaun McCullough (RTI International, United States) and Kymberly Gowdy (The Ohio State University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
Ana Mora (Ohio State University, United States)
"Aging and Senescence, Critical Players in Lung Repair and Disease"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Matthew Campen (University of New Mexico, United States)
"Air Pollution Disruption of Endothelial Barrier Integrity and Angiogenesis: Brain and Placenta as Vulnerable Targets"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
Stavros Garantziotis (NIH, United States)
"Host-Microbiome Interactions in the Pathogenesis of Lung Disease"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
New Modalities, Mechanisms, and Methods in Neurotoxicity
Discussion Leaders: Matthew Wagoner (Takeda Pharmaceuticals, United States) and James (Eric) McDuffie (Neurocrine Biosciences, Inc, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
Timothy Shafer (US Environmental Protection Agency, United States)
"Using New Approach Methodologies (NAMs) to Accelerate and Improve Chemical Hazard Characterization for Developmental Neurotoxicity"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Mohamed Kreir (Janssen Pharmaceutical, Belgium)
"Feasibility Assessment of Microelectrode Array for Early Detection of Proconvulsant Activity for Drug Discovery Compounds"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
Vicencia Toledo Sales (Takeda Pharmaceuticals, United States)
"New Modalities, New Toxicities: A Journey through Neurotoxicity Trends"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
Zakiyah Henry (Rutgers University, United States)
"The Role of Tissue-Restricted FXR Deletion in NASH Development in Mice"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Neha Paranjape (University of Iowa, United States)
"Astrocytes as Targets of Lower Chlorinated Biphenyls: Neurotoxicity and Underlying Mechanisms"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Hannah Coghlan (University of Liverpool, United Kingdom)
"Understanding Species Differences in Hepatic Stress Response Capacity to Help Inform Species Selection for Preclinical Safety Studies"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Mechanisms Regulating Environmental Toxicant Metabolism
Discussion Leaders: Danielle Carlin (National Institute of Environmental Health Sciences, NIH, United States) and Lauren Aleksunes (Rutgers University, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
Jamie Bernard (Michigan State University, United States)
"Adipocyte Modulation of the Aryl Hydrocarbon Receptor: Implications for Metabolism and Carcinogenesis"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Weston Porter (Texas A&M University, United States)
"Tick Tox: Circadian Regulation of PAH Metabolism and Cellular Heterogeneity"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
Jonathan Doorn (University of Iowa, United States)
"Organochlorines and Metabolites as Mediators of Neurotoxicity: Cellular Targets and Mechanisms"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Modern Approaches in Developmental Toxicity Testing
Discussion Leaders: Kari Sant (San Diego State University, United States) and Jessica LaRocca (Corteva Agriscience, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
George Daston (P&G, United States)
"Predicting Developmental Toxicity with Cheminformatics and Transcriptomics"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
Maria Bondesson (Indiana University, United States)
"Identification of Developmental Toxicants and Modes of Action by Multi-Omics in Zebrafish"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
Thomas Knudsen (US EPA, United States)
"Computational (in silico ) Cellular Dynamics in Developmental Toxicity"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
Christy Lite Samuel (University of Texas at Austin, United States)
"Peritubular Macrophage Polarity and Spermatogonial Stem Cell Dynamics in Acute Sertoli Cell Toxicant-induced Testicular Injury Model"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
Jennifer Cossaboon (UC Davis School of Veterinary Medicine, United States)
"Investigating Novel Mechanisms of Ovarian Endocrine Disruption using scRNA-Seq and a Translational Fish Model"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
Subham Dasgupta (Clemson University, United States)
"Flame Retardant Tetrabromobisphenol A (TBBPA) Disrupts Embryogenesis During Zebrafish Zygotic Genome Activation"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
A Mechanistic View of Mixtures Toxicology from Human Health to Ecological Health
Discussion Leader: Phillip Wages (Estee Lauder Companies, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
Cynthia Rider (NIEHS, United States)
"Using New Approach Methodologies to Deconvolute Complex Mixtures"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
Paul Price (Risk Sciences International, United States)
"Advances in Understanding Mechanisms of Toxicological Interactions: Implications for Component-Based Approaches to Characterizing Mixture Risks to Humans"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
Wibke Busch (Helmholtz Centre for Environmental Research - UFZ, Germany)
"Chemical Mixtures in the Environment - Mechanisms of Toxicity and Predictions of Combined Effects from the Molecular to the Ecosystem Scale"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Early Career Investigators in Mechanistic Toxicology
Discussion Leaders: Cassandra Meakin (Gradient , United States) and Katelyn Lavrich (Toxicologist, United States)
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
Cody Smith (University of Connecticut, United States)
"Pulmonary Lipids, Inflammation, and Ozone Toxicity"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
Mohit Jain (UCSD, Sapient Bioanalytics, United States)
"Use of Next Generation Mass Spectrometry to Map Markers of Toxicity"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
Laura Booth (Newcastle University, United Kingdom)
"Cardiomyocyte Senescence in Anthracycline-Induced Cardiotoxicity"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
Cody Schmidlin (Eli Lilly and Company, United States)
"Nonclinical Safety Assessment via a Liver Microphysiological System Informs Dose Selection of Pharmaceutical Molecules"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
Tiago Marques Pedro (University of Cambridge, United Kingdom)
"Building Predictive Models for Mitochondrial Toxicity Using Machine Learning"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
Gagandeep Kaur (University of Rochester Medical Center, United States)
"Cell-Specific Toxicity of Tobacco and Other Flavored e-cig Aerosols in Mouse Lungs Using Single Cell RNA Sequencing and Bioinformatics"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Mechanisms of Protein Degradation by Immunomodulatory Drugs and Targeted Protein Degraders
Discussion Leader: Jorrit Hornberg (AstraZeneca, United States)
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:15 pm
Eric Fischer (Harvard Medical School / Dana Farber Cancer Institute, United States)
"Lessons from Thalidomide and Targeted Protein Degraders for the Development of Protein Degradation Therapeutics"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:05 pm
Kevin Moreau (AstraZeneca, United Kingdom)
"Functional and Mechanistic Safety Profiling of Targeted Protein Degraders"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure