Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Gene Essentiality and Functional Genomics for Mechanistic Toxicology
7:40 pm - 7:45 pm
Introduction by Discussion Leader
7:45 pm - 8:25 pm
"Modernizing Toxicology to Affect Radical Change: Ideation, Evolution, and Application of New Technologies"
8:25 pm - 8:35 pm
Discussion
8:35 pm - 9:15 pm
"Large-Scale Human Genetics in Drug Target Discovery and Safety Assessment"
9:15 pm - 9:25 pm
Discussion
9:25 pm - 9:30 pm
General Discussion
Monday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Artificial Intelligence in Toxicology and its Role in Decision Making
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Deep Learning using HTS Transcriptomics to Predict DILI"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Integrating Whole-Brain Scanning Microscopy with Artificial Intelligence and Neural Network Analysis for High-Throughput Quantitative Assessment of Neurotoxicity and Neurodegeneration"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
"Drug and Target Safety Modeling Using Big/Complex Data and Machine Learning"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
"The Role of Myeloid-Expressed Heme Oxygenase-1 (HO-1) in Ozone-Induced Pulmonary Injury, Antioxidant Responses, and Altered Heme Metabolism"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Exposure to Perfluorooctanesulfonic Acid (PFOS) Increases the Formation of Proinsulin Disulfide-Linked Complexes in Pancreatic BetaTC-6 Cells"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Spatial Investigation of Stress and Inflammation in the Healthy and Susceptible Lung"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
The Cellular Microenvironment in Tissue Health, Disease and Toxic Exposure Outcomes
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"Aging and Senescence, Critical Players in Lung Repair and Disease"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Air Pollution Disruption of Endothelial Barrier Integrity and Angiogenesis: Brain and Placenta as Vulnerable Targets"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
"Host-Microbiome Interactions in the Pathogenesis of Lung Disease"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
New Modalities, Mechanisms, and Methods in Neurotoxicity
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Using New Approach Methodologies (NAMs) to Accelerate and Improve Chemical Hazard Characterization for Developmental Neurotoxicity"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Feasibility Assessment of Microelectrode Array for Early Detection of Proconvulsant Activity for Drug Discovery Compounds"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
"New Modalities, New Toxicities: A Journey through Neurotoxicity Trends"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
"The Role of Tissue-Restricted FXR Deletion in NASH Development in Mice"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Astrocytes as Targets of Lower Chlorinated Biphenyls: Neurotoxicity and Underlying Mechanisms"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Understanding Species Differences in Hepatic Stress Response Capacity to Help Inform Species Selection for Preclinical Safety Studies"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Mechanisms Regulating Environmental Toxicant Metabolism
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"Adipocyte Modulation of the Aryl Hydrocarbon Receptor: Implications for Metabolism and Carcinogenesis"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Tick Tox: Circadian Regulation of PAH Metabolism and Cellular Heterogeneity"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
"Organochlorines and Metabolites as Mediators of Neurotoxicity: Cellular Targets and Mechanisms"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Modern Approaches in Developmental Toxicity Testing
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:35 am
"Predicting Developmental Toxicity with Cheminformatics and Transcriptomics"
9:35 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Identification of Developmental Toxicants and Modes of Action by Multi-Omics in Zebrafish"
10:15 am - 10:25 am
Discussion
10:25 am - 10:55 am
Coffee Break
10:55 am - 11:25 am
"Computational (in silico ) Cellular Dynamics in Developmental Toxicity"
11:25 am - 11:35 am
Discussion
11:35 am - 11:45 am
"Peritubular Macrophage Polarity and Spermatogonial Stem Cell Dynamics in Acute Sertoli Cell Toxicant-induced Testicular Injury Model"
11:45 am - 11:50 am
Discussion
11:50 am - 12:00 pm
"Investigating Novel Mechanisms of Ovarian Endocrine Disruption using scRNA-Seq and a Translational Fish Model"
12:00 pm - 12:05 pm
Discussion
12:05 pm - 12:15 pm
"Flame Retardant Tetrabromobisphenol A (TBBPA) Disrupts Embryogenesis During Zebrafish Zygotic Genome Activation"
12:15 pm - 12:20 pm
Discussion
12:20 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
A Mechanistic View of Mixtures Toxicology from Human Health to Ecological Health
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:05 pm
"Using New Approach Methodologies to Deconvolute Complex Mixtures"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:40 pm
"Advances in Understanding Mechanisms of Toxicological Interactions: Implications for Component-Based Approaches to Characterizing Mixture Risks to Humans"
8:40 pm - 8:45 pm
Discussion
8:45 pm - 9:15 pm
"Chemical Mixtures in the Environment - Mechanisms of Toxicity and Predictions of Combined Effects from the Molecular to the Ecosystem Scale"
9:15 pm - 9:20 pm
Discussion
9:20 pm - 9:30 pm
General Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Discuss Future Dates and Venue; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Early Career Investigators in Mechanistic Toxicology
9:00 am - 9:05 am
Introduction by Discussion Leader
9:05 am - 9:30 am
"Pulmonary Lipids, Inflammation, and Ozone Toxicity"
9:30 am - 9:35 am
Discussion
9:35 am - 10:00 am
"Use of Next Generation Mass Spectrometry to Map Markers of Toxicity"
10:00 am - 10:05 am
Discussion
10:05 am - 10:30 am
"Cardiomyocyte Senescence in Anthracycline-Induced Cardiotoxicity"
10:30 am - 10:35 am
Discussion
10:35 am - 11:05 am
Coffee Break
11:05 am - 11:30 am
"Nonclinical Safety Assessment via a Liver Microphysiological System Informs Dose Selection of Pharmaceutical Molecules"
11:30 am - 11:35 am
Discussion
11:35 am - 11:55 am
"Building Predictive Models for Mitochondrial Toxicity Using Machine Learning"
11:55 am - 12:00 pm
Discussion
12:00 pm - 12:20 pm
"Cell-Specific Toxicity of Tobacco and Other Flavored e-cig Aerosols in Mouse Lungs Using Single Cell RNA Sequencing and Bioinformatics"
12:20 pm - 12:25 pm
Discussion
12:25 pm - 12:30 pm
General Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Keynote Session: Mechanisms of Protein Degradation by Immunomodulatory Drugs and Targeted Protein Degraders
7:30 pm - 7:35 pm
Introduction by Discussion Leader
7:35 pm - 8:15 pm
"Lessons from Thalidomide and Targeted Protein Degraders for the Development of Protein Degradation Therapeutics"
8:15 pm - 8:25 pm
Discussion
8:25 pm - 9:05 pm
"Functional and Mechanistic Safety Profiling of Targeted Protein Degraders"
9:05 pm - 9:15 pm
Discussion
9:15 pm - 9:20 pm
General Discussion
9:20 pm - 9:30 pm
Closing Remarks
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure