| SUNDAY, JULY 12TH | EVENING SESSION: NEW DEVELOPMENTS FROM YOUNG INVESTIGATORS |
Discussion Leader: Antony F. McDonagh, UC San Francisco
- 7:30-7:45 PM Welcoming Remarks
- 7:45-8:55 PM Discussion Leader Introduction
- 7:55-8:20 PM John T. Murphy, Scripps Research Institute
"The Phytofluors: A New Class of Fluorescent Protein Probes"
- 8:20-8:35 PM Discussion
- 8:35-9:00 PM Susan L. Elrod, California Polytechnic State University, San Luis Obispo
"Heme Pathway Engineering Leads to Increased Hemoprotein Secretion in Filamentous Fungi"
- 9:00-9:15 PM Discussion
- 9:15-9:40 PM Angela Wilks, UC San Francisco
"Receptor-mediated Heme Transport: Its Role in Bacterial Pathogenesis"
- 9:40-9:55 PM Discussion
| MONDAY, JULY 13TH | MORNING SESSION: ENZYMOLOGY OF TETRAPYRROLE BIOSYNTHESIS: STRUCTURE-FUNCTION STUDIES |
Discussion Leader: Diter von Wettstein, Washington State University
- 9:00-9:10 AM Discussion Leader Introduction
- 9:10-9:50 AM Gloria C. Ferreira, University of South Florida
"Mammalian ALA Synthase"
- 9:50-10:05 AM Discussion
- 10:05-10:35 AM Coffee Break
- 10:35-11:15 AM Jon Cooper, University of Southampton, UK
"Structure of Eukaryotic and Prokaryotic ALADs"
- 11:15-11:30 AM Discussion
- 11:30-12:10 PM Mats Hansson, Lund University, Sweden
"Structure and Mechanism of Bacterial Ferrochelatase"
- 12:10-12:25 PM Discussion
- 12:25-12:40 PM General Discussion
| EVENING SESSION: TETRAPYRROLE CHEMISTRY |
Discussion Leader: Kevin M. Smith, UC Davis
- 7:30-7:40 PM Discussion Leader Introduction
- 7:40-8:20 PM Kenneth S. Suslick, University of Illinois, Urbana
"Dendrimer-Metalloporphyrins
Synthesis And Catalysis"
- 8:20-8:35 PM Discussion
- 8:35-9:15 PM David A. Lightner, University of Nevada, Reno
"New Synthetic Bilirubins. Hydrogen Bonding, Stereochemistry and Elimination"
- 9:15-9:30 PM Discussion
- 9:30-9:45 PM General Discussion
| TUESDAY, JULY 14TH | MORNING SESSION: TETRAPYRROLE-PROTEIN REGULATORS OF GENE EXPRESSION |
Discussion Leader: Mark R. O'Brian, SUNY Buffalo
- 9:00-9:10 AM Discussion Leader Introduction
- 9:10-9:50 AM Marie A. Gilles-Gonzalez, Ohio State University
"FixL - A Bacterial Oxygen Sensor"
- 9:50-10:05 AM Discussion
- 10:05-10:35 AM Coffee Break
- 10:35-11:15 AM David M. Kehoe, Carnegie Institution of Washington
"Complementary Chromatic Adaptation in Cyanobacteria"
- 11:15-11:30 AM Discussion
- 11:30-12:10 PM Michael S. Denison, UC Davis
"Activation of the Mammalian AHR by Linear Tetrapyrroles"
- 12:10-12:25 PM Discussion
- 12:25-12:40 PM General Discussion
| EVENING SESSION: STRUCTURE-FUNCTION OF CHLOROPHYLL-PROTEIN COMPLEXES |
Discussion Leader: Gregory W. Schmidt, University of Georgia
- 7:30-7:40 PM Discussion Leader Introduction
- 7:40-8:20 PM Petra Fromme, Technical University of Berlin, Germany
"Crystallization and structural model of Photosystem I"
- 8:20-8:35 PM Discussion
- 8:35-9:15 PM C. Neil Hunter, University of Sheffield, UK
"Genetic modification of bacteriochlorophyll binding sites in bacterial light harvesting complexes"
- 9:15-9:30 PM Discussion
- 9:30-9:45 PM General Discussion
| WEDNESDAY, JULY 15TH | MORNING SESSION: STRUCTURE/MECHANISM OF METALLOTETRAPYRROLE ENZYMES |
Discussion Leader: Paul R. Ortiz de Montellano, UC San Francisco
- 9:00-9:10 AM Discussion Leader Introduction
- 9:10-9:50 AM Rolf Thauer, Max-Planck-Institut für Terrestrische Mikrobiologie. Marburg, Germany
"Methyl-Coenzyme M Reductase"
- 9:50-10:05 AM Discussion
- 10:05-10:35 AM Coffee Break
- 10:35-11:15 AM James P. Collman, Stanford University
"Chemistry of Oxygen Activation"
- 11:15-11:30 AM Discussion
- 11:30-12:10 PM Judith N. Burstyn, University of Wisconsin
"Guanylyl Cyclases"
- 12:10-12:25 PM Discussion
- 12:25-12:40 PM General Discussion
| EVENING SESSION: BIOTECHNOLOGICAL APPLICATIONS OF TETRAPYRROLES |
Discussion Leader: Martin Warren, UCL UK
- 7:30-7:40 PM Discussion Leader Introduction
- 7:40-8:20 PM Darren Magda, Pharmacyclics, Inc
"Properties and Clinical Applications of Expanded Porphyrins"
- 8:20-8:35 PM Discussion
- 8:35-9:15 PM Elisabeth Remy, Rhone Poulenc Rorer SA
"B12 Biosynthesis in Pseudomonas denitrificans: Latest developments"
- 9:15-9:30 PM Discussion
- 9:30-9:45 PM General Discussion
| THURSDAY, JULY 16TH | MORNING SESSION: TETRAPYRROLE METABOLISM IN DISEASE AND HEALTH |
Discussion Leader: Mahin D. Maines, University of Rochester School of Medicine
- 9:00-9:10 AM Discussion Leader Introduction
- 9:10-9:50 AM James P. Kushner, University of Utah
"Human Uroporphyrinogen Decarboxylase Deficiency States
Insights from the Crystal Structure of URO-D"
- 9:50-10:05 AM Discussion
- 10:05-10:35 AM Coffee Break
- 10:35-11:15 AM Ida S. Owens, NNICHHD
"Crigler-Najjar Syndrome: BR Glucuronosyl Transferase"
- 11:15-11:30 AM Discussion
- 11:30-12:10 PM Phyllis A. Dennery, Stanford University
"Understanding the Role of Heme Oxygenase in Oxidant Stress Using Transgenic Models"
- 12:10-12:25 PM Discussion
- 12:25-12:40 PM General Discussion
| AFTERNOON WINE AND CHEESE RECEPTION 4:00-6:00 PM |
| EVENING SESSION: BUSINESS MEETING AND KEYNOTE ADDRESS |
- 7:30-8:00 PM Business Meeting
- 8:00-9:00 PM Keynote Address Gerald S. Marks, Queen's University, Ontario
"Mechanism of action of nitro vasodilators: Implications for the arginine-nitric oxide and heme-carbon monoxide pathways."
- 9:00-9:15 PM General Discussion
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