| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | EMERGING TECHNOLOGIES: GENOMICS AND BEYOND |
| Discussion Leader: Mark O'Brian (State Univ. New York at Buffalo) |
| 7:30 pm - 8:30 pm | Peter H. Quail (University of California, Berkeley)
"Phytochrome Signaling Networks" |
| 8:30 pm - 9:30 pm | Claudia Schmidt-Dannert (University of Minnesota)
“Creation of New Biosynthetic Pathways using Directed Evolution and Combinatorial Strategies” |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ENZYMOLOGY OF TETRAPYRROLE BIOSYNTHESIS |
| Discussion Leader: Martin Warren (Queen Mary, University of London) |
| 9:00 am - 10:00 am | Osamu Nakajima (Yamagata University, Japan)
"In Vivo Analysis of Erythroid-specific Aminolevulinate Synthase Function" |
| 9:45 | Group Photo |
| 10:00 am | Coffee Break |
| 10:30 am - 11:30 am | Eileen Jaffe (Fox Chase Cancer Center, Philadelphia)
"Porphobilinogen Synthase or ALAD, Whatever You Call It, It's a Fascinating Family of Enzymes" |
| 11:30 am - 12:30 pm | Dieter Jahn (Technical University Braunschweig, Germany)
"Glutamyl-tRNA Reductase and Coproporphyrinogen III Oxidases: Enzymatic Mechanisms and Their Structural Basis" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | SUPRAMOLECULAR AND DYNAMIC COMBINATORIAL CHEMISTRY |
| Discussion Leader: Kevin Smith (Louisiana State University) |
| 7:30 pm - 8:30 pm | Jeremy K. M. Sanders (Cambridge University, UK)
"Porphyrins and Dynamic Combinatorial Libraries" |
| 8:30 pm - 9:30 pm | Jonathan L. Sessler (University of Texas at Austin)
"Synthesis and Applications of Novel Polypyrrole Macrocycles" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | IRON TRANSPORT AND METAL REGULATION OF TETRAPYRROLE METABOLISM |
| Discussion Leader: Ann Smith (University of Missouri) |
| 9:00 am - 10:00 am | Sabeeha Merchant (UCLA)
"Copper-nutrition dependent Synthesis and Function of Chlorophyll Proteins" |
| 10:00 am | Coffee Break |
| 10:30 am - 11:30 am | Roland Lill (Universität Marburg, Germany)
"Iron Transport and Maturation of Cellular Fe-S Proteins" |
| 11:30 am - 12:30 pm | Cecile Wandersman (Institute Pasteur, France)
"Structure and Function of Bacterial Hemophores" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | PLANT TETRAPYRROLES |
| Discussion Leader: Bernhard Grimm (Humboldt University, Berlin, Germany) |
| 7:30 pm - 8:30 pm | Klaus Apel (Swiss Federal Institute of Technology Zürich, Switzerland)
"A Genetic Approach Towards Understanding the Control of Tetrapyrrole Biosynthesis" |
| 8:30 pm - 9:30 pm | Joanne Chory (The Salk Institute)
"The Role of Tetrapyrroles in Intracellular Signaling from the Chloroplast to the Nucleus in Plants" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | NOVEL FACETS OF HEME |
| Discussion Leader: Paul R. Ortiz de Montellano (University of California, San Francisco) |
| 9:00 am - 10:00 am | Peter Kroneck (University of Konstanz, Germany)
"Multiheme Proteins and Enzymes: From Structure to Electron Transfer to Reaction Mechanism" |
| 10:00 am | Coffee Break |
| 10:30 am - 11:30 am | Kenton Rodgers (North Dakota State University)
"Recent Insights into the Signal transduction Mechanism of the O2-sensing Protein FixL" |
| 11:30 am - 12:30 pm | Michael Marletta (University of California, Berkeley)
"Guanylate Cyclase and NO Signaling" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | TETRAPYRROLE CATABOLISM: LINEAR TETRAPYRROLES AND SIGNALING MECHANISMS |
| Discussion Leader: Tony McDonagh (University of California, San Francisco) and Tadashi Yoshida (Yamagata University) |
| 7:30 pm - 8:30 pm | Tadashi Yoshida (Yamagata University, Japan)
"10-min overview on Biliverdin Reductase" |
| 7:30 pm - 8:30 pm | Timothy J. Mantle (Trinity College, Ireland)
"The Enzymology of Biliverdin Reduction" |
| 8:30 pm - 9:30 pm | Nicole Frankenberg (University of California, Davis)
"Bilin Reductases in Plants and Cyanobacteria" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | HEME-MEDIATED SIGNAL TRANSDUCTION AND CLINICAL IMPLICATIONS |
| Discussion Leader: James Kushner (University of Utah) |
| 9:00 am - 10:00 am | Jane-Jane Chen (Harvard-MIT Div. Health Sciences and Technology)
"Heme-regulated eIF2a Kinase: Translational Control and Beyond " |
| 10:00 am | Coffee Break |
| 10:30 am - 11:30 am | Mitchell Weiss (Children's
Hospital of Philadelphia)
"New Insights into Hemoglobin Biology" |
| 11:30 am - 12:30 pm | Max Gassmann (University of Zurich, Switzerland)
"Oxygen-dependent and independent Erythropoietin Gene Expression: Coping with a Hematocrit of 80-90%" |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 5:00 pm - 6:00 pm | Poster Session with Presenters
|
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | BUSINESS MEETING AND KEYNOTE ADDRESS (ALEXANDER M. CRUICKSHANK LECTURE) |
| 7:30 pm - 8:15 pm | Business Meeting |
| 8:15 pm - 9:30 pm | Keynote Address |
| Discussion Leader: Gloria C. Ferreira (University of South Florida) |
| Greg Petsko, 2002 A. M. Cruickshank Lecturer (Brandeis University)
"The Origin of Enzymatic Species" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
