SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Reflections on a Career / Presentations by Young Investigators |
7:40 pm - 8:00 pm | Discussion Leader: Peter Shoolingin-Jordan(University of Southampton, United Kindom) "Reflections On a Career in the Chemistry & Biology of Tetrapyrroles" |
8:00 pm - 8:20 pm | Chihiro Kitatsuji (Kyoto University, Japan) "A Mechanism for Heme-Mediated Oxidative Modification of the Iron Response Regulator" |
8:20 pm - 8:30 pm | Discussion |
8:30 pm - 8:50 pm | Bernhard Kraeutler (University of Innsbruck, Austria) "Fluorescent Chlorophyll Catabolites in Bananas" |
8:50 pm - 9:00 pm | Discussion |
9:00 pm - 9:20 pm | Raymond Doty (University of Washington, USA) "The Heme Export Protein FLVCR is Essential for Red Blood Cell Development and Iron Homeostasis" |
9:20 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Tetrapyrroles in Oxidative Metabolism |
| Discussion Leader: Kenton Rodgers (North Dakota State University, USA) |
9:00 am - 9:40 am | Eric Hegg (Michigan State University, USA) "Heme A Synthase: An Unusual Enzyme Catalyzing an Unusual Reaction" |
9:40 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo (10:15 am) |
10:30 am - 11:10 am | Emma Raven (University of Leicester, United Kingdom) "The Oxidative Modification and Degradation of Heme in Biological Systems" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Nicola Brasch (Kent State University, USA) "Cobalamins, Nitric Oxide and Oxidative Stress: Exploring a New, Novel Role for Vitamin B12" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Tetrapyrroles as Signals and Regulators of Metabolism |
| Discussion Leader: Nicole Frankenberg-Dinkel (Ruhr-Universität Bochum, Germany) |
7:30 pm - 8:10 pm | Åsa Strand (Umea University, Sweden) "In vivo Visualization of Mg-ProtoporphyrinIX, a Coordinator of Photosynthetic Gene Expression in the Nucleus and the Chloroplast" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Carl Bauer (University of Indiana, USA) "Heme, Light and Redox Control of Tetrapyrrole Gene Expression in R. capsulatus" |
9:10 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Heme Uptake and Transport |
| Discussion Leader: Cécile Wandersman (Institut Pasteur, France) |
9:00 am - 9:40 am | Iqbal Hamza (University of Maryland, College Park, USA) "Eukaryotic heme trafficking" |
9:40 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Erik Skaar (Vanderbilt University Medical Center, USA) "The Adaptability of Gram Positive Pathogens to Growth in Vertebrate Blood" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Dabney Dixon (Georgia State University, USA) "Heme Binding Proteins Associated with an ABC Transporter in S.pyogenes" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Tetrapyrroles in Solar Energy Conversion |
| Discussion Leader: Craig Jolley (Arizona State University, USA) |
7:30 pm - 8:10 pm | Donald Bryant (Pennsylvania State University, USA) "Bacteriochlorophyll c Biosynthesis and its Assembly into Supramolecular Nanorods in Chlorosomes" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | John Shelnutt (Sandia National Laboratories, USA) "Light-Harvesting by Self-Assembled Tetrapyrrole Nanostructures" |
9:10 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Metal Insertion into Tetrapyrroles |
| Discussion Leader: Mats Hansson (Lund University, Sweden) |
9:00 am - 9:40 am | Salam Al-Karadaghi (Lund University, Sweden) "Mg- and Co-chelatase - Insights into the Organization of the ATP-Fueled AAA+ Motor" |
9:40 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:10 am | William Lanzilotta (University of Georgia, USA) "Molecular Mobility in the Ferrochelation Reaction" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | C Neil Hunter (University of Sheffield, United Kingdom) "Mechanistic Studies of Magnesium Chelatase" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Heme in Infectious Disease: Malaria |
| Discussion Leader: Angela Wilks (University of Maryland, USA) |
7:30 pm - 8:10 pm | Maria Mota (University of Lisbon, Portugal) "Heme - In the Center Stage of Severe Malaria?" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Timothy Egan (University of Cape Town, South Africa) "Hemozoin, a Unique Drug Target in Blood-Feeding Organisms. Unravelling Its Mechanism of Formation and the Search for New Drugs for Malaria" |
9:10 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Emerging Roles for Heme in Regulation |
| Discussion Leader: Marie Alda Gilles-Gonzalez (University of Texas-Southwestern Medical Center, USA) |
9:00 am - 9:40 am | Feng Guo (UCLA School of Medicine, USA) "Heme and MicroRNA Maturation" |
9:40 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Toru Shimizu (Tohoku University, Japan) "Heme-Binding Proteins Associated with Transcription of Circadian Rhythms" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Almira Correia (University of California, San Francisco, USA) "Activation of a Hepatic Heme-regulated eIF2α kinase (HRI) in Acute Heme Deficiency: Implications for Acute Hepatic Porphyria" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 8:15 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
8:15 pm - 9:30 pm | What We Have Learned from Heme Protein Structures |
| Discussion Leader: Paul Ortiz de Montellano (University of California, San Francisco, USA) |
8:15 pm - 9:10 pm | Thomas Poulos (University of California, Irvine, USA) "Functional Lessons from Heme Protein Structures" |
9:10 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |