SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | HEME DEGRADATION: OXIDATIVE STRESS AND CELLULAR FUNCTION |
| Discussion Leader: Paul R. Ortiz de Montellano (University of California at San Francisco, USA) |
7:40 pm - 8:20 pm | Stephen W. Ragsdale (University of Michigan, USA) "Thiol-disulfide redox switches that regulate heme-binding to proteins" |
8:20 pm - 8:35 pm | Discussion |
8:35 pm - 9:15 pm | Mahin D. Maines (University of Rochester, USA) "Human biliverdin reductase; a bridge at the crossroads of multiple signal transduction pathways" |
9:15 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | HEME BIOSYNTHESIS: GENES, PROTEINS AND DISEASE |
| Discussion Leader: Jean Charles Deybach (University of Paris, FRANCE) |
9:00 am - 9:40 am | Barry H. Paw (Harvard Medical School, USA) "Mitoferrin solute carriers and their role in vertebrate heme synthesis in the mitochondria" |
9:40 am - 10:00 am | Discussion |
10:00 am | Coffee Break / Group Photo (10:15 am) |
10:30 am - 11:10 am | Sharon D. Whatley (University of Cardiff, UK) "Molecular basis of human protoporphyria" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | John D. Phillips (University of Utah, USA) "Efficient decarboxylation: What works and why" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | LIGHT HARVESTING PIGMENTS: STRUCTURE, FUNCTION AND REGULATION |
| Discussion Leader: Alison Smith (University of Cambridge, UK) |
7:30 pm - 8:10 pm | Jesse Woodson (Salk Institute, USA) "Tetrapyrroles and chloroplast to nucleus communication in Arabidopsis" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Matthew J. Terry (University of Southampton, UK) "Regulation of chlorophyll synthesis by light and plastid signals" |
9:10 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | TETRAPYRROLE ENZYMES: CATALYSIS AND REACTIVITY |
| Discussion Leader: Gloria Ferreira (University of Southern Florida, USA) |
9:00 am - 9:40 am | Jennifer L. DuBois (University of Notre Dame, USA) "Making Dioxygen using Heme : O-O Bond Formation by Chlorite Dismutase" |
9:40 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Martin J. Warren (University of Kent, UK) "Putting tetrapyrroles in their place - the assembly of an organelle specifically for cobalamin dependent enzymes" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | C.S. Raman (University of Maryland, Baltimore, USA) "How do novel functions evolve from existing heme protein scaffolds?" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | TETRAPYRROLES: NEW METHODOLOGIES IN CATALYSIS AND CHEMISTRY |
| Discussion Leader: Kevin Smith (Louisiana State University, USA) |
7:30 pm - 8:10 pm | Silviu Balaban (Karlsruhe Institute of Technology, Germany) "Biomimetic Light-harvesting" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | R. David Britt (University of California at Davis, USA) "Multifrequency EPR studies of biliverdin-derived radical intermediates in the bilin reductase enzyme pcyA" |
9:10 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | HEME TRANSPORTERS, SENSORS AND REGULATORS |
| Discussion Leader: Bill Lanzilotta (University of Georgia, USA) |
9:00 am - 9:40 am | Carla V. Finkielstein (Virginia Polytechnic Institute, USA) "Cross-talk mechanisms link circadian pathways to metabolic conditions" |
9:40 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Stuart J. Ferguson (University of Oxford, UK) "Complexity and Diversity in making the thioether bonds to heme in c-type cytochromes" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Mark R. O’Brian (SUNY at Buffalo) "Heme-mediated control of metal homeostasis" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | TETRAPYRROLES AS IMAGING AND THERAPEUTIC MOLECULES |
| Discussion Leader: Graça H. Vicente (Louisiana State University, USA) |
7:30 pm - 8:10 pm | Zeev Gross (Technion-Israel Institute of Chemistry, Israel) "Metalocorroles for cellular and whole animal imaging and as therapeutic molecules" |
8:10 pm - 8:30 pm | Discussion |
8:30 pm - 9:10 pm | Gang Zheng (University of Toronto, Canada) "New roles for porphyrins in molecular imaging and therapy" |
9:10 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | HEME IN INFECTIOUS DISEASE |
| Discussion Leader: Eric Skaar (Vanderbilt University, USA) |
9:00 am - 9:40 am | Cecile Wandersman (Institute Pasteur, France) "Iron extraction from heme: hammer or forceps" |
9:40 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:10 am | Bernard Meunier (Palumed, FRANCE) "Heme as trigger and target for trioxane-containing antimalarial drugs" |
11:10 am - 11:30 am | Discussion |
11:30 am - 12:10 pm | Amanda G. Oglesby (University of Colorado at Denver, USA) "Heme regulation in Pseudomonas aeruginosa" |
12:10 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:15 pm | KEYNOTE ADDRESS |
| Discussion Leader: Nicole Frankenburg-Dinkel (Ruhr-University, Bochum, Germany) |
8:00 pm - 8:50 pm | J. Clark Lagarias (University of California at Davis, USA) "Lord of the broken rings: From near UV to near IR and back again" |
8:50 pm - 9:15 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |