SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Hot Topics |
| Discussion Leader: John Phillips (University of Utah School of Medicine) |
7:40 pm - 8:00 pm | Liang Yin (Indiana University at Bloomington)
"Heme as a signal molecule in Rhodobacter sphaeroides" |
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Hazel Girvan (University of Manchester)
"Biophysical characterization of DGCR8; the heme binding component of the microRNA synthesis pathway" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | David Wright (Vanderbilt University)
"Finding the pathway: Identifying lead compound that target heme detoxification from phenotypic antimalarial assays" |
9:10 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | B12 |
| Discussion Leader: Bernhard Kräutler (University of Innsbruck) |
9:00 am - 9:30 am | Yan Kung (MIT)
"Molecular gymnastics of a B12-dependent methyltransferase complex"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Montserrat Elias-Arnanz (University of Murcia)
"Triggering bacterial gene expression by B12 and protoporphyrin IX-based light sensing"
|
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Group Photo / Coffee Break |
11:00 am - 11:30 am | David Rosenblatt (McGill University Health Centre)
"Vitamin B12 transport and metabolism: lessons from Mendelian disease"
|
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Markos Koutmos (University of Health Sciences)
"CblC, a mutifunctional B12 processing protein"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Bacterial Tetrapyrrole Metabolism |
| Discussion Leader: Gunhild Layer (TU-Braunschweig) |
7:40 pm - 8:00 pm | Susana Lobo (Instituto De Tecnologia Quimica E Biologica)
"Alternative heme biosynthesis in Desulfovibrio vulgaris"
|
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Nicole Frankenberg-Dinkel (Ruhr-University Bochum)
"A heme-based redox-sensor in the methanogenic archaeon Methanosarcina acetivorans"
|
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Celia Goulding (UC Irvine)
"How M. tuberculosis acquires iron from heme"
|
9:10 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Chemistry of Tetrapyrroles |
| Discussion Leader: Emma Raven (University Of Leicester) |
9:00 am - 9:30 am | Yi Lu (University of Illinois)
"Designing functional metalloenzymes containing heme or its analogs, exploring the role of non-covalent interactions in conferring and fine-tuning enzymatic activities"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Dilek Dogutan (MIT)
"Small molecule activation with hangman porphyrins and hangman corroles"
|
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | P.L. Dutton (University of Pennsylvania)
"A new protein design family that assembles novel synthetic chorins and porphyrins for a variety of functions"
|
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Christiane Knappke (Oxford University)
"Porphyrin nanorings"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Heme In Human Physiology |
| Discussion Leader: Pavel Martasek (Charles University) |
7:40 pm - 8:00 pm | Anthony J. Kettle (University of Otago Christchurch)
"The chemistry and biology of myeloperoxidase in infection and inflammation"
|
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Eileen Jaffe (Fox Chase Cancer Center)
"The dance of porphobilinogen synthase in the control of tetrapyrrole biosynthesis"
|
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Feng Guo (UCLA)
"A role of heme in microRNA processing" |
9:10 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Tetrapyrroles In Disease States |
| Discussion Leader: Peter Meissner (University of Cape Town) |
9:00 am - 9:30 am | David Bishop (Mt. Sinai School of Medicine)
"Novel genetic heterogeneity in X-linked sideroblastic anemia: Mutations that do not reduce ALAS2 activity in vitro"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Sarah Ducamp (Hospital Louis Mourier)
"ALAS2 and heme production for erythropoiesis: lesson from XLDPP"
|
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Barry Paw (Brigham & Women's Hospital, Harvard Medical School)
"Atpif1 and other components involved in mitochondrial heme homeostasis in erythroblasts"
|
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | M.P. Soares (Instituto Gulbenkian De Ciencia)
"A central role for heme in host-pathogen interaction"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Tetrapyrrole Metabolism In Parasites And Pathogens |
| Discussion Leader: Amy Medlock (University of Georgia) |
7:40 pm - 8:00 pm | Neil Hammer (Vanderbilt University School of Medicine)
"S. aureus modulates heme trafficking in order to optimize respiration during infection"
|
8:00 pm - 8:15 pm | Discussion |
8:15 pm - 8:35 pm | Iqbal Hamza (University of Maryland)
"Eukaryotic heme trafficking"
|
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:10 pm | Akhil Vaidya (Drexel University)
"The conundrum of heme biosynthesis by malaria parasites"
|
9:10 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am - 9:00 am | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
9:00 am - 12:30 pm | Tetrapyrroles In Photosynthetic Organisms |
| Discussion Leader: Neil Hunter (University of Sheffield) |
9:00 am - 9:30 am | Robert Blankenship (Washington University, Saint Louis)
"Chlorophyll-containing antenna complexes in photosynthetic organisms"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Min Chen (University of Sydney)
"Biosynthetic pathway of Chl d and Chl f"
|
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Roman Sobotka (Institute of Microbiology, Laboratory of Photosynthesis, Czech Republic)
"What is the place where chlorophyll and protein meet each other? Integration of chlorophyll biosynthesis into Photosystem II assembly machinery in the cyanobacterium Synechocystis 6803"
|
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Stefan Hortensteiner (University of Zurich)
"Chlorophyll breakdown"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Lecture |
7:30 pm - 7:45 pm | Conclusion of Business Meeting |
| Final Election of 2014 Vice Chair |
7:45 pm - 8:00 pm | Discussion Leader: Felix de Rooij (Erasmus University Medical Center, Rotterdam)
"Introduction of Keynote Speaker" |
8:00 pm - 9:00 pm | J.H. Paul Wilson (Erasmus University Medical Center, Rotterdam)
"Why Me Dear Lord: Phenotype Variablity in the Porphyrias"
|
9:00 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |