Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Chlorophyll, Light Harvesting Systems and Tetrapyrroles that Produce Energy |
| Discussion Leader: Neil Hunter (University of Sheffield, United Kingdom) |
7:40 pm - 8:10 pm | Gongfang Hu (North Carolina State University, USA) "Panchromatic Light-Harvesting Architecture: New Designs for Tetrapyrroles in Artificial Photosynthesis" |
8:10 pm - 8:25 pm | Discussion |
8:25 pm - 8:55 pm | Roman Sobotka (Institute of Microbiology, Czech Academy of Sciences, Czech Republic) "Corralling the Colours: Regulation of Photosynthetic Tetrapyrroles" |
8:55 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Toni Mingers (Braunschweig University of Technology, Germany) "Late Steps in Tetrapyrrole Synthesis and Heme Transport" |
9:25 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Chemistry of Tetrapyrroles |
| Discussion Leader: Kara Bren (University of Rochester, USA) |
9:00 am - 9:35 am | Ekaterina Pletneva (Dartmouth College, USA) "The
Role of Conformational Dynamics in Defining Redox Function of Cytochrome c" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Matthew Liptak (University of Vermont, USA) "Non-Canonical Heme Oxygenases: A New Chapter of Heme-Oxygen Chemistry" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:35 am | Ricardo Louro (ITQB, Universidade Nova de Lisboa, Portugal) "NMR
Studies of Multiheme Cytochromes c
from Anaerobic Bacteria that Use Metals to Sustain Their Bioenergetic Metabolism" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Elisa Tomat (University of Arizona, USA) "Urinary Biopyrrins: From Heme Metabolites to Redox-Active Ligands" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Amit Redddi (Georgia Institute of Technology, USA) "Heme Gazing: Elucidating Heme Trafficking, Dynamics, and Signaling with Fluorescent Heme Sensors" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Linear Tetrapyrroles in Biology |
| Discussion Leader: J. Clark Lagarias (University of California, Davis, USA) |
7:30 pm - 8:00 pm | Jeff Tabor (Rice University, USA) "Optogenetic Applications of Bilin-Based Light Sensors" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Beronda Montgomery (Michigan State University, USA) "Tetrapyrrole-Binding Tryptophan-Rich Sensory Protein (TSPO) Is Involved in Stress-Related and Light-Dependent Processes in the Cyanobacterium Fremyella diplosiphon" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Joanne Blanchfield (University of Queensland, Australia) "Mechanistic Evaluation of the Inhibition of Polyaromatic Mutagens by Endogenous Bile Pigments" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Edson Rocha (Brody School of Medicine, East Carolina University, USA) "Heme-Iron Utilization in the Gut Commensal and Opportunistic Anaerobe Pathogen Bacteroides fragilis Is Dependent on the Ferrous Iron Transporter FeoAB" |
9:25 pm - 9:30 pm | Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | The Next 50 Years of Chlorophyll |
| Discussion Leader: Samuel Beale (Brown University, USA) |
9:00 am - 9:35 am | Robert Blankenship (Washington University in St. Louis, USA) "Neutron Crystal Structure and Redox-Activated Quenching of the FMO Photosynthetic Antenna Protein" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Fei Gan (The Scripps Research Institute, USA) "FaRLiP and LoLiP: Alternative Mechanisms for Acclimation to Far Red and Low Light in Terrestrial Cyanobacteria" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:35 am | Robert Willows (Macquarie University, Australia) "New Regulatory Mechanisms in Chlorophyll Biosynthesis" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Gunhild Layer (Leipzig University, Germany) "Enzymatic In Vitro Synthesis of Cofactor F430" |
12:00 pm - 12:05 pm | Discussion |
12:05 pm - 12:20 pm | Amanda Brindley (University of Sheffield, United Kingdom) "Unravelling Protein-Protein Interactions Within the Magnesium Chelatase Enzyme Complex" |
12:20 pm - 12:25 pm | Discussion |
12:25 pm - 12:30 pm | General Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | The Synthesis, Biology and Use of Cobalamine |
| Discussion Leader: Amy Medlock (University of Georgia, USA) |
7:30 pm - 8:00 pm | Martin Warren (Unversity of Kent, United Kingdom) "Developing a Synthetic B12 Pathway" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Markos Koutmos (Uniformed Services University of the Health Sciences, USA) "A Structural Look at Cytosolic B12 Metabolism" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Molly Sutherland (Washington University in St. Louis, USA) "Heme Trafficking and Modifications in the Prokaryotic Cytochrome c Biogenesis Pathways" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Alhosna Benjdia (INRA / Université Paris Saclay, France) "TsrM, a Unique B12-Dependent Radical SAM Enzyme: Catalysis of Unprecedented Methyl Transfer Reaction in Thiostrepton A Biosynthesis" |
9:25 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Heme Biosynthesis in Disease |
| Discussion Leader: Robert Desnick (Icahn School of Medicine at Mount Sinai, USA) |
9:00 am - 9:35 am | Marcelo Bozza (Universidade Federal do Rio de Janeiro, Brazil) "Heme Activates Macrophages Through Innate Immune Receptors and ROS" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Bill Querbes (Alnylam Pharmaceuticals, USA) "A Novel siRNA for Acute Intermittent Porphyria" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:35 am | Tania Baker (Massachusetts Institute of Technology, USA) "Managing the Rate Limiting Step in Heme Biosynthesis by ClipX" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Barbara Wegiel (Beth Israel Deaconess Medical Center, USA) "Heme Activates Cancer Metastases via Modulation of DNA Secondary Structures" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Xiaojing Yuan (University of Maryland, College Park, USA) "Regulation of Intracellular Heme Trafficking Revealed by Subcellular Reporters" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | The Pathobiology of Heme: Tetrapyrroles and Host Microbe Interactions |
| Discussion Leader: Miguel Soares (Fundação Calouste Gulbenkian, Instituto Gulbenkian Ciência, Portugal) |
7:30 pm - 8:00 pm | Solomon Ofori-Acquah (University of Pittsburgh, USA) "Role and Mechanism of Heme in the Pathogenesis of Acute Lung Injury in Sickle Cell Anemia" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Malay Haldar (Perelman School of Medicine, University of Pennsylvania, USA) "Heme Activation of SPI-C" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Jan Perner (Institute of Parasitology, Biology Centre, Czech Academy of Sciences, Czech Republic) "Acquisition of Exogenous Haem Is Essential for Tick Reproduction" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Jose Maria Perez-Victoria (Instituto de Parasitologia y Biomedicina "Lopez-Neyra", CSIC, Spain) "Trypanosomatid Parasites Rescue Heme from Endocytosed Hemoglobin Through Lysosomal HRG Transporters" |
9:25 pm - 9:30 pm | Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Synthesis and Optimal Use of Vitamin B12 |
| Discussion Leader: Michiko Taga (University of California, Berkeley, USA) |
9:00 am - 9:35 am | Olivier Berteau (Micalis Institute, INRA, France) "Radically New Reactions: Emergence of the B12 / Radical SAM Enzymes" |
9:35 am - 9:45 am | Discussion |
9:45 am - 10:20 am | Montserrat Elias-Arnanz (University of Murcia, Spain) "Light Regulation of Gene Expression by a B12-Dependent Photoreceptor" |
10:20 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:35 am | Wyatt Yue (University of Oxford, United Kingdom) "Journey of Vitamin B12 Through the Human Processing and Trafficking Pathways" |
11:35 am - 11:45 am | Discussion |
11:45 am - 12:00 pm | Julia Cricco (National University of Rosario, Argentina) "Trypanosoma cruzi, a Heme Auxotroph Parasite, Could Restrict the Intracellular Heme Content Through Its Transport" |
12:00 pm - 12:10 pm | Discussion |
12:10 pm - 12:25 pm | Florian Widner (Institute of Organic Chemistry, University of Innsbruck, Austria) "Functional Misfit in the Goblin Vitamin – Revelations from the Rhodium-Analogue of Coenzyme B12" |
12:25 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | The Diseases of Heme and Porphyrin Biosynthesis |
| Discussion Leader: Sylvia Bottomley (University of Oklahoma College of Medicine, USA) |
7:30 pm - 8:40 pm | Michael Marletta (University of California, Berkeley, USA) "Heme in Chemistry, Medicine and Biology" |
8:40 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |