Sunday, July 6
Evening Session, 7:30 pm
DRUG METABOLISM: PAST, PRESENT AND FUTURE - Keynote Lecture
- Patrick J. Murphy (Eli Lilly & Co.)
Monday, July 7
Morning Session, 9:00 am - 12:30 pm
APPLICATION OF BASIC KNOWLEDGE OF CYTOCHROME P450 TO UNDERSTANDING AND PREDICTION OF METABOLISM - PART 1
Discussion Leader: Henry W. Strobel (University of Texas-Houston Medical School)
- Leslie Z. Benet (University of California-San Francisco) - "An Overview of the Importance of Recent Advances in P450 Knowledge"
- Byron W. Kemper (University of Illinois) - "Site-Directed Mutagenesis Studies of Mammalian Microsomal P450 Structure"
- Julian A. Peterson (University of Texas Southwest Medical School) - "X-Ray Crystal Structures of Soluble P450s"
Evening Session, 7:30 - 9:30 pm
APPLICATION OF BASIC KNOWLEDGE OF CYTOCHROME P450 TO UNDERSTANDING AND PREDICTION OF METABOLISM - PART 2
Discussion Leader: Henry W. Strobel (University of Texas-Houston Medical School)
- David F. V. Lewis (University of Surrey) - "Homology Modeling of Mammalian P450 3-D Structures"
- John H. Dawsonr (University of South Carolina) - "Mechanistic Studies of Cytochrome P450-CAM Using Camphor Analogues"
Tuesday, July 8
Morning Session, 9:00 am - 12:30 pm
APPROACHES TO UNDERSTANDING AND PREDICTION OF DRUG INDUCTION OF CYTOCHROME P450 IN HUMANS
Discussion Leader: Lewis J. Klunk (Bristol-Myers Squibb)
- David J. Waxman (Boston University) - "Liver P450 Enzyme Induction: Pathways and Molecular Mechanisms"
- Steven A. Wrighton (Eli Lilly & Co.) - "Models to Study the Induction of Human Cytochrome P450"
- Paul B. Watkins (University of Michigan Medical Center) - "Clinical Methods to Study Enzyme Induction in Man"
Evening Session, 7:30 - 9:30 pm
NOVEL ASPECTS OF GLUTATHIONE-S-TRANSFERASE-MEDIATED DRUG METABOLISM
Discussion Leader: Deborah Nicoll-Griffith (Merck Frosst)
- Richard N. Armstrong (Vanderbilt University) - "Fosfomycin Resistance Protein (FosA) is a Metallo Glutathione Transferase Related to Glyoxalase I and the Extradiol Dioxygenases"
- Gerard J. Mulder (University of Leiden) - "Modulation of Glutathione Conjugation In Vivo"
Wednesday, July 9
Morning Session, 9:00 am - 12:30 pm
THE CLINICAL IMPORTANCE OF DRUG INTERACTIONS INVOLVING P450: A REALITY CHECK
Discussion Leader: Paul B. Watkins (University of Michigan Medical Center)
- Kenneth B. Thummel (University of Washington) Title : "CYP 2E 1 and Acetaminophen Hepatotoxicity"
- Kim Brosen (Institute of Medical Biology, Odense, Denmark) - "CYP2D6 and Psychiatric Medications"
- Paul B. Watkins (University of Michigan Medical Center) - "CYP3A4 and Immunosuppressants, Antihistamines, Antivirals, and the Birth Control Pill"
Evening Session, 7:30 - 9:30 pm
RECENT ADVANCES IN OUR UNDERSTANDING OF FREE RADICALS AND ANTIOXIDANTS
Discussion Leader: Prasarn Manitpisitkul (Bristol-Myers Squibb)
- Prasarn Manitpisitkul (Bristol-Myers Squibb) - "An Overview of Free Radicals and the Protective Role of Antioxidants in Biological Systems "
- Jeffrey B. Blumberg (Tufts University) - "Free Radicals, Antioxidants, and Chronic Diseases: Results of Human Studies"
Thursday, July 9
Morning Session, 9:00 am - 12:30 pm
DRUG TRANSPORTERS AND METABOLIC ENZYMES: SYNERGISTIC FORCES TO LIMIT XENOBIOTIC ACCESS
Discussion Leader: Leslie Z. Benet (University of California-San Francisco)
- Leslie Z. Benet (University of California-San Francisco) - "The Intestine"
- Kim L. R. Brouwer (University of North Carolina) - "The Liver"
- Kathleen M. Giacomini (University of California-San Francisco) - "The Kidney"
Evening Session, 7:30 - 9:30 pm
ANALYTICAL ADVANCES IN DRUG METABOLISM
Discussion Leader: Ronald E. White (Bristol-Myers Squibb)
- Ian A. Blair (University of Pennsylvania) - "Chemical Reaction Interface Mass Spectrometry as a Practical Alternative to Radioactivity in Drug ADME Studies"
- Ken Turteltaub (Lawrence Livermore Laboratories) - "Applications of Accelerator Mass Spectrometry in Drug Metabolism: Attomole Measurement Capabilities in Real World Samples"
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