Sunday July 4, 1999
Evening Session; 7:30 PM | KEYNOTE LECTURE |
WELCOMING REMARKS
Steven A. Wrighton
What does the new millennium hold for the global pharmaceutical industry?
Cecil B. Pickett
Schering-Plough Research Institute
Kenilworth, NJ
Monday July 5, 1999
Morning session, 9:00 AM - 12:30 PM | COMPLEXITIES OF THE INTESTINAL FIRST-PASS EFFECT |
Discussion leader:
Kenneth Thummel
University of Washington
Seattle, WA
Pharmacokinetic evaluation and inhibition of intestinal first-pass metabolism.
Cheryl Zimmerman
University of Minnesota
Minneapolis, MN
First-pass drug metabolism in a Caco-2 monolayer model: Testing
the free-drug hypothesis.
Kenneth Thummel
Coordinate intestinal transport proteins and metabolic enzymes as
barriers to oral drug delivery.
Leslie Z. Benet
UCSF School of Pharmacy
San Francisco, CA
Monday July 5, 1999
Evening session, 7:30 - 9:30 PM | REGULATION OF CYTOCHROMES P450 2B AND 3A |
Discussion leader:
Erin Schuetz
St. Jude Children's Research Hospital
Memphis, TN
Nuclear orphan receptor CAR mediates phenobarbital induction of
the CYP2B genes.
Masa Negishi
National Institute of Environmental Health Sciences
Research Triangle Park, NC
Transcriptional control of the CYP3A gene.
Erin Schuetz
Tuesday July 6, 1999
Morning session, 9:00 AM - 12:30 PM | GENETIC VARIATION OF DRUG CONJUGATION
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Discussion leader:
Brain Burchell
Introduction and genetic variation of drug glucuronidation by the UGT1 gene super
family.
Brian Burchell
Genetic variations in the UGT2B gene family.
Dean W. Hum
Laval University
Quebec, Canada
Molecular genetics of bioactivation of minoxidil by cutaneous sulfotransferases.
Tom Dooley
Southern Research Institute
Birmingham, AL
Genetic variation of thiopurine methytransferase.
William Evans
St. Jude Children's Research Hospital
Memphis, TN
Tuesday July 6, 1999
Evening session, 7:30 - 9:30 PM | NOVEL ASPECTS OF PHARMACOGENETICS |
Discussion leader:
Rachel Tyndale
University of Toronto
Toronto, Canada
The role of pharmacogenetic variation in drug metabolism on the risk for drug dependence.
Rachel Tyndale
Evaluating the effect of single nucleotide polymorphisms in the CYP2 and CYP4 families.
Allan Rettie
University of Washington
Seattle, WA
Wednesday July 7, 1999
Morning session, 9:00 AM - 12:30 PM | NEW TECHNOLOGIES AND APPROACHES FOR DRUG METABOLISM IN DRUG DISCOVERY |
Discussion Leader:
Cosette J. Serabjit-Singh
Glaxo Wellcome
Research Triangle Park, NC
Increasing the throughput and predictivity of in vitro screens for drug disposition.
Ivin Silver
Glaxo Wellcome
Research Triangle Park, NC
Physicochemical databases useful for prediction of drug disposition characteristics.
Christopher Lipinski
Pfizer Inc.
Groton, CT
Computational structural biology and the assessment of drug metabolism by human hepatic P450s.
Gilda Loew
Molecular Research Institute
Palo Alto, CA
The structure of Microsomal P450 2C5
Eric Johnson
Scripps Research Institute
La Jolla, CA
Wednesday July 7, 1999
Evening session: 7:30 - 9:30 PM | GENDER AND PEDIATRIC DIFFERENCES IN DRUG METABOLISM |
Discussion leader:
Stephen D. Hall
Indiana University School of Medicine
Indianapolis, IN
Application of phenotyping studies to drug biotransformation in the first
years of life: Pitfalls and promises.
J. Steven Leeder
The Children's Mercy Hospital
Kansas City, MO
Human CYP3A activity in vivo: The interaction of advanced age and gender.
Stephen D. Hall
Thursday July 8, 1999
Morning session, 9:00 AM - 12:30 PM | ACTIVITIES AND REGULATION OF THE CYP4A SUBFAMILY |
Discussion leader:
Henry Strobel
University of Texas Medical School
Houston, TX
PPARa - regulated expression of genes responsible for microsomal and peroxisomal fatty acid metabolism.
Janardan Reddy
Northwestern University Medical School
Chicago, IL
Regulation of CYP4A subfamily in models of inflammation.
Edward T. Morgan
Emory University School of Medicine
Atlanta, GA
The rabbit CYP4A gene subfamily (CYPs 4A4 - 4A7): How different are they?
Bettie Sue Masters
Department of Biochemistry, U.T.H.S.C. - S.A.
San Antonio, TX
Thursday July 8, 1999
Evening session, 7:30 - 9:30 PM | ADVANCES IN BIOANALYTICAL TECHNIQUES |
Discussion leader:
William J. Ehlhardt
Lilly Research Laboratories
Indianapolis, IN
Applications of LC-NMR in drug metabolism.
Steven R. Maple
Lilly Research Laboratories
Indianapolis, IN
LC-MS: An elegant tool for drug metabolism participation in new drug discovery.
Walter A. Korfmacher
Schering-Plough Research Institute
Kenilworth, NJ
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