| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and check-in |
| 5:00 pm - 6:00 pm | Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Lecture |
| Ronald E. White, Ph.D. (Schering-Plough Research Institute)
"The Golden Age of Drug Discovery" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Group Photo |
| 9:00 am - 12:30 pm | Drug Transporters in the Drug Discovery and Development Process |
| Discussion Leader: Bill J. Smith, Ph.D. (Pfizer) |
| 9:00 am - 9:45 am | Joseph W. Polli, Ph.D. (GlaxoSmithKline, Inc.)
"The Intestinal Absorption of an NMDA Receptor Antagonist Is Limited in Mice by the P-Glycoprotein (Pgp) and Breast Cancer Resistance Protein (Bcrp) Efflux Transporters" |
| 9:45 am - 10:30 am | Deborah A. Nicoll-Griffith, Ph.D. (Merck Frosst Centre for Therapeutic Research)
"Overcoming Hepatic Uptake and Efflux Issues in a Drug Discovery Program" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Jasminder Sahi, Ph.D. (Pfizer)
"Use of Transporter Assays to Understand Renal and Hepatic Disposition of New Drug Candidates" |
| 11:45 am - 12:30 pm | Keith Hoffmaster, Ph.D. (University of North Carolina, Chapel Hill)
"Pharmacokinetic Consequences of Multiple Transporters Involved in Hepatobiliary Disposition: In Vitro Data Demonstrate Complexities of In Vivo Interpretations" |
| 12:30 pm | Lunch |
| 1:30 pm - 5:00 pm | Free Time |
| 5:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | New Advances in Analytical Technologies |
| Discussion Leader: Walter Korfmacher, Ph.D. (Schering-Plough) |
| 7:30 pm - 8:10 pm | Richard King, Ph.D. (Merck)
"QTrap LC-MS/MS Technology: Enabling More Complete Analysis of Samples from Drug Metabolism Studies" |
| 8:10 pm - 8:50 pm | Mark Sanders, Ph.D. (Bristol-Myers Squibb)
"Practical Applications of LC/FTMS in Support of Metabonomics and Metabolite ID Studies" |
| 8:50 pm - 9:30 pm | Daniel Chelsky, Ph.D. (Caprion Pharmaceuticals)
"Biomarker Analysis as a Decision Making Tool in Drug Discovery and Development" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | New Insights into Mechanisms of CYP Enzyme and Transporter Induction |
| Discussion Leader: Erin Schuetz, Ph.D. (St. Judes Childrens' Research Hospital, Memphis, TN) |
| 9:00 am - 9:45 am | John Schuetz, Ph.D. (St. Judes Childrens' Research Hospital, Memphis, TN)
"Biological Interactions Revealed by ABC Transporter and Nuclear Receptor Knockouts" |
| 9:45 am - 10:30 am | Wen Xie, M.D., Ph.D. (University of Pittsburgh)
"Orphan Nuclear Receptor-mediated Genetic and Pharmacological Regulation of Drug Metabolizing Enzymes" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | David Moore, Ph.D. (Baylor College of Medicine, Houston, TX)
"Protective and Deleterious Effects of CAR Activation" |
| 11:45 am - 12:30 pm | Erin Schuetz, Ph.D. (St. Judes Childrens' Research Hospital, Memphis, TN)
"Regulation of Gene Expression from Brain to Liver by PXR and CAR" |
| 12:30 pm | Lunch |
| 1:30 pm - 5:00 pm | Free Time |
| 5:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Predicting Metabolism, Induction, and Inhibition |
| Discussion Leader: Rommel Tirona, Ph.D. (Amgen) |
| 7:30 pm - 8:10 pm | Leslie Z. Benet, Ph.D. (University of California, San Francisco)
"Inhibition and Induction of Drug Metabolizing Enzymes and Transporters on Bioavailability and Organ Clearance" |
| 8:10 pm - 8:50 pm | K. Sandy Pang, Ph.D (University of Toronto)
"Modeling Intestinal Drug Absorption and Metabolism" |
| 8:50 pm - 9:30 pm | Rommel Tirona, Ph.D. (Amgen)
"In Vitro Approaches to Predict Drug Metabolizing Enzyme and Transporter Induction" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Pharmacogenetics and Pharmacogenomics: Are we there yet? |
| Discussion Leader: David A. Katz, Ph.D. (Abbott Laboratories) |
| 9:00 am - 9:05 am | David A. Katz, Ph.D. (Abbott Laboratories)
Overview |
| 9:05 am - 9:45 am | Julia Kirchheiner, M.D. (University of Cologne)
"Pharmacogenetics-based Therapeutic Recommendations in Clinical Practice" |
| 9:45 am - 10:25 am | David A. Katz, Ph.D. (Abbott Laboratories)
"Using Pharmacogenetics to Understand Pharmacokinetics of New Chemical Entities" |
| 10:25 am | Coffee Break |
| 10:45 am - 11:25 am | Peter M. Shaw, Ph.D. (Bristol-Myers Squibb)
"Pharmacogenetic Approaches and Applications for Drug Development" |
| 11:25 am - 12:05 pm | James M. Rae, Ph.D. (University of Michigan)
"The Pharmacogenetics of Tamoxifen Response" |
| 12:05 pm - 12:30 pm | Panel Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 5:00 pm | Free Time |
| 5:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Oral Presentations of Selected Posters |
| Discussion Leader: Henry W. Strobel, Ph.D. (University of Texas Medical School, Houston) |
| Auinash Kalsotra (University of Texas Medical School, Houston)
"LTB4 Metabolism by CYP4Fs:A Checkpoint in Inflammation Control" |
| Sayeepriyadarshini Anakk (University of Texas Medical School, Houston)
"CAR/PXR Provide Directives for CYP3a41 Gene Regulation Differently From CYP3all" |
| Wei Lu (University of Toronto)
"Oxidation of Carbamazepine and Phenytoin Metabolites to Free Radicals and Possible Correlation With Changes in In Vivo Gene Expression Reflecting Cell Stress" |
| Lauren Aleksunes (University of Connecticut)
"Transcriptional Regulation of Hepatic Transporter and Detoxification Genes During Liver Injury Induced by Acetaminophen and Carbon Tetrachloride" |
| Hartmut Glaeser (Vanderbilt University)
"Membrane-associated Expression of Organic Anion Transporting Polypeptides -A and -C in Human Small Intestine" |
| H. Sun (University of California, San Francisco)
"A Furan Dicarboxylic Acid and Indole Sulfate are Putative Inhibitors of Erythromycin Hepatic Uptake and Metabolism" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Biochemistry of Drug-induced Cellular Damage |
| Discussion Leader: F. Peter Guengerich, Ph.D (Vanderbilt University) |
| 9:00 am - 9:45 am | F. Peter Guengerich, Ph.D (Vanderbilt University)
"Bioactivation of Chemicals and Reaction with Macromolecules: Relevance to Toxicity" |
| 9:45 am - 10:30 am | Mohammed Bourdi, Ph.D (LMI, NHLBI, NIH)
"Role of Pro-Toxicant and Protective Factors in Determining Susceptibility to Drug-Induced Liver Injury" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Neil Kaplowitz, M.D. (University of Southern California)
"Cellular and Intercellular Mechanisms of Drug Hepatotoxicity" |
| 11:45 am - 12:30 pm | Roger Ulrich, Ph.D., D.A.B.T (Rosetta/Merck)
"Molecular Profiling of Adverse Drug Responses" |
| 12:30 pm | Lunch |
| 1:30 pm - 5:00 pm | Free Time |
| 5:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Clinical Spectrum and Implication of Drug-induced Hepatotoxicity |
| Discussion Leader: Paul B. Watkins, M.D. (University of North Carolina) |
| 7:30 pm - 8:10 pm | Paul B. Watkins, M.D. (University of North Carolina)
"Clinical Approaches to Study Drug Induced Liver Injury" |
| 8:10 pm - 8:50 pm | Ronald P. Oude Elferink, Ph.D. (Academic Medical Center, Amsterdam, the Netherlands)
"Transporters and Hepatoxicity" |
| 8:50 pm - 9:30 pm | Munir Pirmohamed, Ph.D., FRCP, FRCP(E) (University of Liverpool)
"Idiosyncratic Drug Reactions Affecting the Liver: A Clinical Perspective" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
