| SUNDAY |
| 2:00 pm - 9:00 pm | Arrival and Check-in |
| 5:00 pm - 6:00 pm | Reception |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Keynote Lecture |
| Paul R. Ortiz de Montellano, Ph.D. (University of California, San Francisco) |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Group Photo |
| 9:00 am - 12:30 pm | Advances in the Basic Knowledge of Cytochrome P450 Towards the Understanding of Drug Metabolism: Part 1 - Structure/Function |
| Discussion Leader: Stephen G. Sligar, Ph.D. (University of Illinois at Urbana-Champaign) |
| 9:00 am - 9:45 am | Michael R. Waterman, Ph.D. (Vanderbilt University)
"Streptomyces P450s are a Working Model for New Drug Design" |
| 9:45 am - 10:30 am | Ilme Schlichting, Ph.D. (Max Planck Institute)
"Redoxactive Metal Complexes - Control of Activity via Molecular Architecture" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Eric F. Johnson, Ph.D. (Scripps Research Institute)
"Recent Advances in Structural Characterization of Drug Metabolizing P450 Monooxygenases" |
| 11:45 am - 12:30 pm | Richard N. Armstrong, Ph.D. (Vanderbilt University)
"Kappa: A Different Glutathione Transferase Fold for Oxidative Metabolism and Catabolism" |
| 12:30 pm | Lunch |
| 1:30 pm - 5:00 pm | Free Time |
| 5:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Advances in the Basic Knowledge of Cytochrome P450 Towards the Understanding of Drug Metabolism: Part 2 - Oxidation Reactions |
| Discussion Leader: William M. Atkins, Ph.D. (University of Washington) |
| 7:30 pm - 8:10 pm | Jeffrey P. Jones, Ph.D. (Washington State University)
"Isotope Effects and the (Unified?) Mechanism of P450 Mediated Reactions" |
| 8:10 pm - 8:50 pm | Sason Shaik, Ph.D. (Hebrew University)
"Structure and Reactivity Patterns in P450 Enzymes" |
| 8:50 pm - 9:30 pm | Stephen G. Sligar, Ph.D. (University of Illinois at Urbana-Champaign)
"Intermediate States and Complexity of P450 Metabolism" |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Drug Metabolism-Consequences to Toxicity / Pharmacology |
| Discussion Leader: Judy Bolton, Ph.D. (University of Illinois at Chicago) |
| 9:00 am - 9:45 am | Jim Fishbein, Ph.D. (University of Maryland)
"Molecular Aspects of Cancer Chemoprevention by Dithiolethiones" |
| 9:45 am - 10:30 am | Natalia Tretyakova, Ph.D. (University of Minnesota)
"Mass Spectrometry of DNA and Protein Lesions Induced by Bifunctional Electrophiles" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Gregory R.J. Thatcher, Ph.D. (University of Illinois at Chicago)
"Nitric Oxide, Estrogens, and Oxidative Stress" |
| 11:45 am - 12:30 pm | John M. Essigmann, Ph.D. (Massachusetts Institute of Technology)
"Design of DNA Damaging Agents that Overcome the Apoptotic Blockade of Prostate Cancer Cells" |
| 12:30 pm | Lunch |
| 1:30 pm - 5:00 pm | Free Time |
| 5:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Expression and Tissue Distribution of Drug Metabolizing Enzymes |
| Discussion Leader: Jeffery C. Stevens, Ph.D. (Pfizer) |
| 7:30 pm - 8:10 pm | J. Steven Leeder, PharmD, Ph.D. (The Children's Mercy Hospitals)
"Ontogeny and Tissue-Specific Expression of 'Drug' Metabolizing Enzymes Involved in Fetal Development" |
| 8:10 pm - 8:50 pm | Xinxin Ding, Ph.D. (Wadsworth Center)
"Developmental Expression of Drug Metabolizing Enzymes in the Nasal Mucosa and Lung" |
| 8:50 pm - 9:30 pm | Ronald N. Hines, Ph.D. (Medical College of Wisconsin)
"Developmental Regulation of Human Hepatic FMO1 and FMO3: Molecular Mechanisms and Genetic Variability" |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Integrating Preclinical Information to Predict Human Drug Disposition |
| Discussion Leader: Timothy S. Tracy, Ph.D. (Univ. Minnesota) |
| 9:00 am - 9:45 am | Leslie Z. Benet, Ph.D. (Univ. of California-San Francisco)
"Predicting Drug Disposition via Application of a Biopharmaceutics Drug Disposition Classification System: Transport/Absorption/Elimination Interplay" |
| 9:45 am - 10:30 am | R. Scott Obach, Ph.D. (Pfizer)
"The Utilization of In Vitro Inhibition Data for Projecting Clinical Drug-Drug Interactions - Defining the Unknowns and Leveraging the Knowns" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Mary Paine, Ph.D. (Univ. of North Carolina)
"Pre-Clinical and Clinical 'Appeels' Of Grapefruit Juice-Drug Interactions" |
| 11:45 am - 12:30 pm | Timothy S. Tracy, Ph.D. (Univ. of Minnesota)
"Enzyme (Mis)Behavior: The Effects of Atypical Kinetics and Genotype on Predictions of Drug Disposition and Drug-Drug Interactions" |
| 12:30 pm | Lunch |
| 1:30 pm - 5:00 pm | Free Time |
| 5:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Oral Presentations of Selected Posters |
| Discussion Leader: Henry W. Strobel, Ph.D. (University of Texas Medical School, Houston) |
| Viola Tamasi, Ph.D. (University of Louisville)
"Dehydroepiandrosterone increases PPARa transcriptional activity by increasing levels of non-phosphorylated receptor" |
| Melissa A Kramer (Medical College of Wisconsin)
"Identification of novel CYP2C9 promoter SNPs within the Hispanic population" |
| Justine L Lam (University of California, San Francisco)
"In Vitro and In Vivo Correlation of Hepatic Transporter Effects on Erythromycin (ERY) Metabolism" |
| Jed N Lampe (University of Washington)
"Probing the Cytochrome P450 3A4 Active Site with the Fluorescent Ligand TNS (2(p-Toluidino)naphthalene-6-sulfonate)" |
| Josh T Pearson (University of Washington)
"Surface Plasmon Resonance Analysis of Antifungal Azoles Binding to CYP3A4: Kinetic Resolution of Multiple Binding Orientations" |
| Dustin M Smith (University of Washington)
"Advancing the Human Serum Albumin-CYP2C9 Interaction; a Link Between Spectral and Kinetic Results" |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | Innovative Clinical Approaches in Underwriting Disposition Factors in Early Drug Development |
| Discussion Leader: Paul G. Pearson, Ph.D. (Amgen)
|
| 9:00 am - 9:45 am | Richard Lalonde, Pharm D. (Pfizer)
"Pharmacokinetic / Pharmacodynamic Modeling to Facilitate Accelerated Drug Development" |
| 9:45 am - 10:30 am | Scott Patterson, Ph.D. (Amgen)
"Biomarkers in Early Drug Development" |
| 10:30 am | Coffee Break |
| 11:00 am - 11:45 am | Jenny Chien, Ph.D. (Eli Lilly & Co.)
"Integrating in vitro enzyme kinetics, pharmacokinetics and pharmacodynamics to yield predictive drug-drug interaction models to guide dosing strategy" |
| 11:45 am - 12:30 pm | Richard Hargreaves, Ph.D. (Merck & Co)
"PET Imaging Approaches in Drug Development" |
| 12:30 pm | Lunch |
| 1:30 pm - 5:00 pm | Free Time |
| 5:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Novel Technology Approaches to Applied to Drug Discovery and Development Drug Metabolism |
| Discussion Leader: Kenneth R. Korzekwa, Ph.D. (Merck Research Laboratories) |
| 7:30 pm - 8:10 pm | Daniel E. Murnick, Ph.D. (Rutgers University)
"Laser Based Carbon-14 Atom Counting for Drug Metabolism Studies" |
| 8:10 pm - 8:50 pm | William M. Atkins, Ph.D. (University of Washington)
"Cytochrome P450 and Ligand Dynamics Revealed by Optical Biosensors and Nanodiscs" |
| 8:50 pm - 9:30 pm | Thomas Rushmore, Ph.D. (Merck Research Laboratories)
"Advances in In Vitro Technologies for Drug Metabolism" |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
