SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
5:00 pm - 6:00 pm | Reception |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Keynote Lecture |
| Dennis A. Smith (Pfizer, Sandwich)
"The more I know the easier it was..." |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:45 am | Group Photo |
9:00 am - 12:30 pm | Pharmacogenomics |
| Discussion Leader: Kathleen M. Giacomini (University of California, San Francisco) |
9:00 am - 9:30 am | Kathleen M. Giacomini (University of California, San Francisco)
"Pharmacogenetics of Membrane Transporters" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Mary V. Relling (St. Jude Children's Research Hospital)
"Leukemia Pharmacogenetics: Candidate Gene and Whole Genome Approaches" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | David A. Flockhart (Indiana University School of Medicine)
"The Pharmacogenomics of Drug Metabolism in the Treatment of Breast Cancer" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Walter L. Miller (University of California, San Francisco)
"P450 Oxidoreductase: Genetic Variation and Implications to Drug Metabolism" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:00 pm | Free Time |
5:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Probe Substrates |
| Discussion Leader: Kenneth E. Thummel (University of Washington) |
7:30 pm - 7:55 pm | Evan D. Kharasch (Washington University)
"Can CYP3A Probes Quantitatively Predict the In Vivo Kinetics of Other CYP3A Substrates and Accurately Assess CYP3A Induction and Inhibition?" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Kenneth R. Korzekwa (Merck Research Laboratories)
"Prediction of P450 Mediated Drug Interactions in Development" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Kenneth E. Thummel (University of Washington)
"Factors affecting the full utility of in vivo CYP phenotyping: Is there still a knowledge gap or a fundamental problem?" |
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | In Silico/In Vitro/In Vivo Approaches |
| Discussion Leader: R. Scott Obach (Pfizer, Groton) |
9:00 am - 9:30 am | Michael Mayersohn (University of Arizona)
"Prediction of Drug Disposition Parameters in Humans from Interspecies (allometric) Scaling OR To Extrapolate Is Human, To Be Correct Divine" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Karen Rowland-Yeo (University of Sheffield)
"Prediction of Drug Clearance and Metabolic Drug-Drug Interactions - Known Knowns, Known Unknowns and Unknown Unknowns" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Gabriele Cruciani (University of Perugia)
"Predicting Affinity for and Metabolism by Cytochromes P450" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Franco Lombardo (Novartis, Cambridge)
"Evolution from Animal to Computer: An Accurate Computational Method for the Prediction of Volume of Distribution in Human" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:00 pm | Free Time |
5:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Animals-on-a-Chip |
| Discussion Leader: Michael L. Shuler (Cornell University) |
7:30 pm - 7:55 pm | Michael L. Shuler (Cornell University)
"Animals-on-a-Chip: Towards a Tool for Predictive Toxicology" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Gregory T. Baxter (Hurel Corporation)
"Microfluidic In vivo Surrogate Assay Platforms for Cell-Based Studies" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Shuichi Takayama (University of Michigan)
"Reprogrammable Microfluidics for Animals-on-a-Chip" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Transporters (but not P-gp and MRP2) in the Intestine and Liver |
| Discussion Leader: James E. Polli (University of Maryland, Baltimore) |
9:00 am - 9:30 am | Hiroyuki Kusuhara (University of Tokyo)
"Role of ABC Transporters in Intestinal and Biliary Drug Efflux" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Patrick J. Sinko (Rutgers University)
"The Effect of BCRP-UGT Coupling on Absorption and Disposition of Topotecan" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | James E. Polli (University of Maryland, Baltimore)
"Substrate Requirements of the Apical Sodium-dependent Bile Acid Transporter" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Joseph W. Polli (GlaxoSmithKline, Research Triangle Park)
"Role of the Liver-specific Transporter OATP1B1 in Drug Disposition and Interactions" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:00 pm | Free Time |
5:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Oral Presentations of Graduate Student and Postdoc Posters |
| Discussion Leader: Henry W. Strobel (University of Texas Medical School, Houston) |
7:30 pm - 7:50 pm | Aarti Sawant (University of Illinois Chicago)
"In Vitro Evaluation of Constituents Present in a Commonly Used Hormone Replacement Therapy Agent Using LC-MS-MS" |
7:50 pm - 8:10 pm | Joseph M. Custodio (University of California San Francisco)
"Monoolein Inhibits Carrier-Mediated Transport of Saquinavir in Caco-2 Cells" |
8:10 pm - 8:30 pm | Brooke Vanderbrink (University of Washington)
"Two Metabolic Steps to Inactivated Enzyme: A Study of Atypical MBI Kinetics using Furafylline Analogs and CYP1A2" |
8:30 pm - 8:50 pm | Yan Shu (University of California San Francisco)
"The Organic Cation Transporter 1, OCT1, is Required for Therapeutic Effects of Metformin" |
8:50 pm - 9:10 pm | Carolyn L. Cummins (University of Texas Southwestern - Dallas)
"Liver X Receptors Regulate Adrenal Cholesterol Balance" |
9:10 pm - 9:30 pm | Dong-Mei Cheng (LSU Medical School - New Orleans)
"P450 Interaction Effects the Catalytic Properties of CYP1A2" |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Metabolic Liabilities and Risk Assessment |
| Discussion Leader: Mark P. Grillo (Amgen, South San Francisco) |
9:00 am - 9:30 am | Amit S. Kalgutkar (Pfizer, Groton)
"Lessons Learnt from the Retrospective Analysis of Potential Pathways Leading to Toxicity with Drugs - Applications to Modern Drug Discovery" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Christine M. Dieckhaus (Merck Research Laboratories, West Point)
"Using New Methodologies to Revisit Classic Chemical Reactivities" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Christian Skonberg (Danish University of Pharmaceutical Sciences)
"Metabolic Activation of Acidic Drugs - Multiple Modes of Reactive Metabolite Formation" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Jeffrey F. Waring (Abbott Laboratories)
"Application of Toxicogenomics Towards Idiosyncratic Hepatotoxicity" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 5:00 pm | Free Time |
5:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Regulation |
| Discussion Leader: Wen Xie (University of Pittsburgh) |
7:30 pm - 7:55 pm | Masahiko Negishi (NIEHS)
"CAR-Mediated Regulation of Hepatic Metabolisms" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Melissa Runge-Morris (Wayne State University)
"Transcriptional Regulation of Human Hepatic Hydroxysteroid Sulfotransferase (SULT2A1)" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Wen Xie (University of Pittsburgh)
"Orphan Nuclear Receptor-Mediated Gene Regulation in Drug Metabolism and Liver Diseases" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Depart |