| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
| 7:40 pm - 9:30 pm | Keynote Speaker |
| Tom Baillie (Department of Drug Metabolism, Merck, West Point, PA, USA)
"Bioactivation in Drug Metabolism. How far have we come in understanding the phenomenon?" |
| Discussion |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:45 am | Group Photo |
| 9:00 am - 12:30 pm | Non-CYP Enzymes and Oxidative Metabolism |
| Discussion Leader: Christine Beedham (Clinical Sciences, University of Bradford, UK) |
| 9:00 am - 9:30 am | Christine Beedham (Clinical Sciences, University of Bradford, UK)
"Substrate/inhibitor specificity and generation of reactive oxygen" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Enrico Garratini (Laboratory of Molecular Biology, Mario Negri Institute, Milan, Italy)
"Genetics and evolution of mammalian molybdo-flavoenzymes" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Vasilis Vasiliou (Health Sciences Center, University of Colorado, Denver, USA)
"Non-P450 alcohol and aldehyde metabolising enzymes" |
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | John Cashman (Human BioMolecular Research Institute, San Diego, USA)
"FMO3 and human disease" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Impact of protein-protein interaction on metabolism |
| Discussion Leader: Wayne Backes (Department of Pharmacology, LSU Health Center, New Orleans, LA, USA) |
| 7:30 pm - 7:55 pm | Byron Kemper (Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, IL, USA)
"Influence of Protein-Protein Interactions on the Cellular Localization of Cytochrome P450" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Grover Paul Miller (Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, AR, USA)
"Marriage in the Cytochrome P450 System: How liberal are the protein protein interactions?" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Wayne Backes (Department of Pharmacology, LSU Health Center, New Orleans, LA, USA)
"Interactions between Different P450 Enzymes: How do these Interactions affect P450 function?" |
| 9:15 pm - 9:30 pm | Discussion |
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | In vivo relevance if in vitro transporter tools |
| Discussion Leader: Rommel Tirona (Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada) |
| 9:00 am - 9:30 am | Jose Manautou (Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT, USA)
"Transcriptional and signaling mechanisms regulating drug transporters in drug-induced hepatotoxicity" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | James Polli (School of Pharmacy, University of Maryland, Baltimore, MD, USA)
"In vitro methology issues" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Rommel Tirona (Department of Physiology and Pharmacology, University of Western Ontario, London, Ontario, Canada)
"Variability in transporter activity: in vitro and in vivo" |
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Richard Kim (Department of Medicine, University of Western Ontario, London, Ontario, Canada)
"OATP transporters: In vitro systems vs in vivo in mice and man" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Transporter DDI; pharmacological ramification |
| Discussion Leader: Erin Schuetz (Department of Pharmaceutical Sciences, St. Jude Children's Hospital, Memphis, TN, USA) |
| 7:30 pm - 7:55 pm | Joe Polli (Preclinical Drug Metabolism and Pharmacokinetics, GSK, Research Triangle Park, NC, USA)
"Interplay Between Phase II Enzymes and Transporters" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Jash Unadkat (Department of Pharmaceutics, University of Washington, Seattle, WA, USA)
"Drug interactions at the human blood-brain barrier: fact or fantasy?" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | John Schuetz (Department of Pharmaceutical Sciences, St. Jude Children's Hospital, Memphis, TN, USA)
"Multiple levels of Interplay between ABC Transporters & Nuclear Hormone" |
| 9:15 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | The innate immune system and idiosyncratic drug-induced liver toxicity |
| Discussion Leader: Robert Roth (Department of Pharmacology and Toxicology, Michigan State University, E. Lansing, MI, USA) |
| 9:00 am - 9:30 am | Neil Kaplowitz (USC, Research Center for Liver Diseases, Los Angeles, CA, USA)
"Innate immunity in acetaminophen toxicity" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Patricia Ganey (Department of Pharmacology and Toxicology, Michigan State University, E. Lansing, MI, USA)
"Inflammation-drug interaction: animal models of idiosyncratic hepatotoxicity" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am- | Hisham Hamadeh (Amgen, Inc., Department of Toxicology, Thousand Oaks, CA, USA)
"Role of GI flora in an animal model of p38-inhibitor-induced hepatotoxicity" |
| 11:30 am - 11:45 am | Discussion |
| 11:45 am - 12:15 pm | Edward T. Morgan (Department of Pharmacology, Emory University, Atlanta, GA, USA)
"Inflammation and drug metabolizing enzymes" |
| 12:15 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 7:30 pm - 9:30 pm | Graduate Student and Post-Doctoral Posters |
| Discussion Leader: Henry Strobel (Department of Biochemistry and Molecular Biology, University of Texas-Houston Medical School, Houston, TX, USA) |
| 7:30 pm - 7:45 pm | Speaker 1 (TBA) |
| 7:45 pm - 7:50 pm | Discussion |
| 7:50 pm - 8:05 pm | Speaker 2 (TBA) |
| 8:05 pm - 8:10 pm | Discussion |
| 8:20 pm - 8:25 pm | Speaker 3 (TBA) |
| 8:25 pm - 8:30 pm | Discussion |
| 8:30 pm - 8:45 pm | Speaker 4 (TBA) |
| 8:45 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:05 pm | Speaker 5 (TBA) |
| 9:05 pm - 9:10 pm | Discussion |
| 9:10 pm - 9:25 pm | Speaker 6 (TBA) |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | ADME Computational models |
| Discussion Leader: Scott Boyer (Department of DMPK and Bioanalytical Chemistry, AstraZeneca, Molndol, Sweden) |
| 9:00 am - 9:30 am | Ulf Norinder (Department of DMPK and Bioanalytical Chemistry, AstraZeneca, Södertälje, Sweden)
"Building Robust and Predictive ADMET Computational models" |
| 9:30 am - 9:45 am | Discussion |
| 9:45 am - 10:15 am | Yvonne Martin (Abbott, Waukegan, IL, USA)
"Uses of ADME Models in Drug Discovery" |
| 10:15 am - 10:30 am | Discussion |
| 10:30 am | Coffee Break |
| 11:00 am - 11:30 am | Tudor Oprea (University of New Mexico, Albuquerque, NM, USA)
"Understanding ADMET data: Key to good in silico models" |
| 11:30 am - 11:45 am | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | Disposition and PK/PD of biologics |
| Discussion Leader: David Lau (Johnson and Johnson, CA, USA) |
| 7:30 pm - 7:55 pm | Paul Fielder (Pharmacokinetics and Pharmacodynamic Sciences, Genentech, South San Francisco, CA, USA)
"Protein metabolism and disposition" |
| 7:55 pm - 8:10 pm | Discussion |
| 8:10 pm - 8:35 pm | Honghui Zhou (Clinical Pharmacology, Centocor, Malvern, PA, USA)
"Drug-drug interaction of biologics" |
| 8:35 pm - 8:50 pm | Discussion |
| 8:50 pm - 9:15 pm | Yow-Ming Wang (Pharmacokinetics and Drug Metabolism, Amgen, Thousand Oaks, CA, USA)
"PK/PD of fusion proteins" |
| 9:15 pm - 9:30 pm | Discussion |
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Depart |
