SUNDAY |
2:00 pm - 11:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome by Conference Chair, Timothy S. Tracy Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Opening Session - Drug Metabolism: Past, Present, and Future |
7:40 pm - 9:00 pm | Steven Wrighton (Eli Lilly and Co.) "Drug Metabolism: Past, Present and Future" |
9:00 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:45 am | Group Photo |
9:00 am - 12:30 pm | The P450 Cycle and Kinetics of Substrate Metabolism |
| Discussion Leader: Ken Korzekwa (Allchemie, Inc.) |
9:00 am - 9:30 am | Stephen Sligar (University of Illinois) "Drug metabolism and enzyme ‘cooperativity’" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Jeff Jones (Washington State University) "The differing effects of substrate interactions with the heme-iron: is type II binding a dead-end complex?" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Lucy Waskell (University of Michigan) "Cytochrome b5 catalyzes product formation by P450 2B4 faster than reductase and competes with reductase for a binding site on P450 2B4" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Andrew Munro (University of Manchester) "Transient kinetic studies of Mycobacterium tuberculosis drug target P450s" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | UGT Polymorphisms and Drug Interactions / Adverse Reactions |
| Discussion Leader: Michael Court (Tufts University) |
7:30 pm - 7:55 pm | Philip Lazarus (Penn State University) "UGT pharmacogenetics and breast cancer prevention and treatment" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Christian P. Strassburg (Hannover Medical School, Germany) "Gilbert’s Syndrome: just a variant or more? - UGT variation and drug toxicity" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Chantal Guillemette (Laval University, Canada) "Variability in human UGTs: polymorphisms to new and unique genomic variations" |
9:15 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Novel Metabolism Reactions and Toxicity |
| Discussion Leader: Matthew Hutzler (Pfizer, Inc.) |
9:00 am - 9:30 am | Dan Rock (Amgen, Inc.) "The role of P450 active site architecture in exposure to reactive metabolites" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Jack Uetrecht (University of Toronto, Canada) "Non-P450-generated reactive metabolites and determination of their significance" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Jeffrey Stevens (Pfizer, Inc.) "Impact of FMO-mediated metabolism in drug discovery" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Hansen Wong (Vanderbilt University) "Stress signaling via alkylation of JNK and NF-κB pathway proteins by reactive electrophiles" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Modeling and Simulation in Preclinical and Clinical Drug Development |
| Discussion Leader: Steven Hall (Eli Lilly and Co.) |
7:30 pm - 7:55 pm | Sandra Allerheiligen (Eli Lilly and Co.) "Applications of quantitative pharmacology to drug discovery and development optimization" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Christine Garnett (U.S. Food and Drug Administration) "The utility of modeling and simulation in the new drug evaluation environment" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Geoffrey Tucker (University of Sheffield, United Kingdom) "Integrating demographic, physiological, genetic, and in vitro data: The bottom-up approach to population PK" |
9:15 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Endogenous Substrates of Multi-Functional Drug-Metabolizing Enzymes |
| Discussion Leader: Ken Thummel (University of Washington) |
9:00 am - 9:30 am | Deanna Kroetz (University of California, San Francisco) "Renal EETs and Soluble Epoxide Hydrolase in Acute Kidney Injury" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Rheem Totah (University of Washington) "CYP2C8 and EET formation" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Henry Strobel (University of Texas Medical School at Houston) "CYP4F enzymes and brain metabolism" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Darryl Zeldin (NIEHS) "Role of P450 Epoxygenases in Cardiovascular Function" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
7:30 pm - 9:30 pm | Student/Trainee Presentations |
| Discussion Leader: Henry Strobel (University of Texas Medical School at Houston) |
7:30 pm - 7:45 pm | Student/Trainee Presenter 1 (TBA) |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | Student/Trainee Presenter 2 (TBA) |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Student/Trainee Presenter 3 (TBA) |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Student/Trainee Presenter 4 (TBA) |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Student/Trainee Presenter 5 (TBA) |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Student/Trainee Presenter 6 (TBA) |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Drug Transporters: Structure, Function, Regulation and Clinical Translation |
| Discussion Leader: Kim Brouwer (University of North Carolina at Chapel Hill) |
9:00 am - 9:30 am | Stephen Wright (University of Arizona) "Structure/Function assessment of organic cation transporters (OCTs and MATEs)" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Peter Swaan (University of Maryland) "Structure/Function relationships of bile acid transporters" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Guofeng You (Rutgers University) "Regulation of organic anion transporters (OATs)" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Joseph Ware (Genentech, Inc.) "ABCG2 (BCRP) structure, activity, and clinical translation" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Technologies in Drug Metabolism |
| Discussion Leader: Larry Wienkers (Amgen, Inc.) |
7:30 pm - 7:55 pm | Thomas M. Laue (University of New Hampshire) "Direct physical methods for determining properties of macromolecules and the extent of ligand binding" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Gordon Tollin (University of Arizona) "Plasmon-Waveguide resonance spectroscopy as a tool for understanding membrane protein function" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Jonathan B. Chaires (University of Louisville) "Clinical colorimetry?" |
9:15 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |