SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | ADME Sciences at the Center of Drug Research: Making Better New Drugs and Using Old Drugs Better |
| Discussion Leader: R. Scott Obach (Pfizer) |
7:40 pm - 7:50 pm | R. Scott Obach (Pfizer)
"ADME Sciences at the Center of Drug Research: Making Better New Drugs and Using Old Drugs Better" |
7:50 pm - 9:00 pm | Keynote Speaker: Yuichi Sugiyama (U. Tokyo)
"Drug Transporters: Roles in New Drug Discovery and Development" |
9:00 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | ADME Sciences and Pharmacology |
| Discussion Leader: Lisa Benincosa (Roche) |
9:00 am - 9:30 am | Don Mager (U. Buffalo)
"Bridging PK/PD and Systems Pharmacology Modeling in Oncology" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Megan A. Gibbs (Amgen)
"Quantitative Pharmacology in the Discovery Space: Modeling and Simulation Challenges for Biologics" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Neil Parrott (Roche)
"Physiologically based pharmacokinetic models for small molecules and biologics" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Alison Betts (Pfizer)
"Optimizing design and translational strategy of antibody drug conjugates through PK/PD and systems pharmacology modeling: challenges and opportunities" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ADME Sciences and Toxicology |
| Discussion Leader: Jack Uetrecht (U. Toronto) |
7:30 pm - 8:00 pm | Cynthia Ju (U. Colorado)
"Animal Models of Adverse Drug Reactions" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Gerry Kenna (AstraZeneca)
"Implications of drug transporters and drug transporter interactions for drug safety" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Dean Naisbitt (U. Liverpool)
"Should the hapten hypothesis be used in 2011 to define the chemical basis of immune-mediated idiosyncratic drug toxicity" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ADME Sciences and Clinical Pharmacology Part 1: Modelling and Prediction |
| Discussion Leader: Heidi Einolf (Novartis) |
9:00 am - 9:30 am | Hartmut Derendorf (U. Florida)
"How to handle protein binding in modeling and simulation" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Aleksandra Galetin (U. Manchester)
"Role of PBPK modelling in the assessment of transporter-mediated drug-drug interactions" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Jenny Chien (Eli Lilly)
"Translational Science of Human Pharmacokinetics: Common Methodologies and Case Examples" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Hiroyuki Kusuhara (U. Tokyo)
"Importance of drug transport in clinical PK or target effects" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | ADME Sciences and Clinical Pharmacology Part 2: Special Populations |
| Discussion Leader: J. Steven Leeder (Children's Mercy Hospital, Kansas City) |
7:30 pm - 8:00 pm | Yvonne Lin (U. Washington)
"Identifying CYP2D6 Endogenous Biomarkers using Metabolomics" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Xiaobo Zhong (U. Kansas Medical Center)
"Developmental expression of CYP3A4 mRNA isoforms in hepatocyte maturation, pediatric and adult liver" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Amin Rostami-Hodjegan (U. Manchester)
"In the verge of impossibility: Studying new drugs for infinite permutations of special populations" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ADME Sciences and Pharmaceutics |
| Discussion Leader: Mitchell Taub (Boehringer-Ingelheim) |
9:00 am - 9:30 am | Wei-Chiang Shen (U. Southern California)
"Pharmacokinetics of Recombinant Bifunctional Fusion Proteins" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Tom Raub (Eli Lilly)
"Use of Iterative In Silico-In Vitro-In Vivo Learning Cycles to Optimize Brain Exposure" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Urban Fagerholm (AstraZeneca)
"PK-Matrix: A permeability- and CLint-based reference system for prediction, classification and profiling of human PK" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Yelena Kovtun (ImmunoGen)
"Designing a perfect antibody-drug conjugate for anti-cancer therapy" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Graduate Student and Post-Doc Presentations |
| Discussion Leader: Henry Strobel (U. Texas-Houston) |
7:30 pm - 7:45 pm | Mohamad Elmeliegy (St. Jude's Children's Research Hospital) "Tumor Penetration and Cytotoxicity Studies of a Novel PDGFR Inhibitor, Crenolanib, in High-grade Glioma Models" |
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | Imir Metushi (U. Toronto) "Development of an Animal Model of Isoniazid-Induced Liver Injury" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Karelle Menochet (U. Manchester) "Simultaneous mechanistic modelling of active uptake and metabolism of repaglinide in rat hepatocytes" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Zhican Wang (U. Washington) "Dysregulation of Vitamin D Catabolism by CYP3A4 Induction: A Possible Mechanism of Drug-Induced Osteomalacia" |
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Xiaohai Li (Scripps Research Institute) "Discovery of the first highly selective CYP3A4 vs. CYP3A5 substrate and inhibitors - A focused screening and medicinal chemistry effort" |
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Alex Morgan (U. Western Ontario) "Quantitative in vitro to in vivo prediction of P-glycoprotein-mediated drug transport" |
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | ADME Sciences and Medicinal Chemistry |
| Discussion Leader: J. Scott Daniels (Vanderbilt U.) |
9:00 am - 9:30 am | Deepak Dalvie (Pfizer)
"Role of non-P450 enzymes in drug metabolism: Emerging importance of aldehyde oxidase in drug discovery and lead optimization" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Jan Wahlstrom (Amgen)
"Structure-Based Modulation of DDI: From Chemotype to the Clinic" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Nigel Waters (Novartis)
"Multi-Parametric ADME Optimization in Drug Discovery via Chemometrics and in silico Modeling" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Michael Cameron (Scripps-Florida)
"Generation of reactive metabolites: 'This drug has the same chemical moiety and is well tolerated'" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Ideas and Technologies |
| Discussion Leader: Chandra Prakash (BiogenIdec) |
7:30 pm - 8:00 pm | Andrew Parkinson (Xenotech, LLC)
"Lysosomal trapping: methods of investigation, pharmacokinetic consequences and toxicological implications" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Tonika Bohnert (Biogen Idec)
"Evaluation of Chimeric Mice with Humanized Liver to Predict Human Intrinsic Clearance of Drug Molecules at Preclinical Phase" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Jonathan Josephs (Bristol Myers Squibb)
"Quan/Qual Experiments by Means of High Resolution Full Scan Accurate Mass - The Future of Discovery DMPK?" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |