SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in (Office Closed 6:00 pm - 7:00 pm) |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Celebrating the Future of Drug Metabolism |
7:40 pm - 7:50 pm | Discussion Leader: Erin Schuetz (St. Jude Children's Research Hospital)
"Celebrating the Future of Drug Metabolism" |
7:50 pm - 9:00 pm | Keynote Speaker: Stephen G. Sligar (U. Illinois Urbana, Champaign)
"Drug Metabolism: The Good, The Bad and The Ugly"`
|
9:00 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Metabolomics Meets ADME |
| Discussion Leader: Frank Gonzalez (National Institutes of Health) |
9:00 am - 9:30 am | Frank Gonzalez (National Institutes of Health)
"Toxicity biomarkers and mechanisms revealed by non-targeted metabolomics"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Sanjay K. Nigam (U. California San Diego)
"SLC22 Drug Transporters in Remote Communication Mediated by Metabolites"
|
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Xiaochao Ma (U. Kansas Medical Center)
"Metabolomic Analysis Reveals Novel Mechanisms of the Drug Toxicity"
|
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Sabrina M. Ronen (U. California San Francisco)
"Magnetic Resonance Detectable Biomarkers of Antineoplastic Treatment"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Predicting Metabolism using Cytochrome P450 Structure |
| Discussion Leader: Steven A. Wrighton (Advion Biosciences) |
7:30 pm - 8:00 pm | Eric F. Johnson (Scripps Research Institute)
"Crystalline P450 2D6: An Experimental Platform for Characterization of Substrate and Inhibitor Binding"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Emily E. Scott (U. Kansas)
"Human Cytochrome P450 Active Site Adaptations to Ligand Structure - Within and Between Enzymes"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | James R. Halpert (U. California, San Diego)
"Conformational Plasticity of Mammalian Cytochromes P450 2B: Implications for Prediction of Drug Metabolism from X-ray Crystal Structures"
|
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Environmental and Dietary Factors Affecting Drug Metabolism and Response |
| Discussion Leader: Kenneth Thummel (U. Washington) |
9:00 am - 9:30 am | Mary Paine (U. North Carolina)
"Predicting Interactions between Drugs and Dietary Substances by IVIVE"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Francis Levi (INSERM)
"Moderation of Xenobiotic Effects by Circadian Clocks"
|
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Erik Eliasson (Karolinska Institutet)
"Exploring the Potential Relationship between Individual Levels of Vitamin D and CYP3A-activity"
|
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Allan Rettie (U. Washington)
"Vitamin K Disposition: Generic and Environmental Factors- Implications for Drug Response"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Time Dependent Inhibition |
| Discussion Leader: Andrew Parkinson (XPD Consulting) |
7:30 pm - 8:00 pm | Andrew Parkinson (XPD Consulting)
"The Impact of Experimental Design on the in vitro Assessment of Metabolism-Dependent Inhibition of CYP Enzymes"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Stephen D. Hall (Eli Lilly)
"Translation of Time-Dependent Inhibition Data into Clinical DDI Predictions"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Scott R. Obach (Pfizer)
"Challenges in the Prediction of CYP3A-based Drug-Drug Interactions from in vitro Time Dependent Inhibition: From Experimental rigor to Appropriate Modeling"
|
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Mice with Human Livers or Human ADME Genes for Drug Disposition Studies |
| Discussion Leader: Robert H. Tukey (U. California, San Diego) |
9:00 am - 9:30 am | C. Roland Wolf (U. Dundee)
"Application of Transgenic Animal Models to Predict Human Responses to Drugs and Chemical Toxins"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Anshul Gupta (AstraZeneca)
"Humanized liver chimeric mouse-for assessing the impact of binding to human alpha-acid glycoprotein on metabolic clearance of compounds in a discovery program"
|
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Robert Tukey (U. California, San Diego)
"Intestinal Glucuronidation in Humanized and Conditional Knockout Animal Models"
|
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | John Bial (Yecuris)
"Chimeric Animal Models: Emerging Tools in Translational Medicine"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Graduate Student and Post-Doc Presentations |
| Discussion Leader: Henry Strobel (University of Texas, Houston Medical School) |
7:30 pm - 7:45 pm | John Thomas Barr (Washington State University)
"Impact of Probe Substrate Selection on Aldehyde Oxidase Inhibition Profiles: Implications for Mechanism and in Vitro DDI Prediction"
|
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | Klarissa Hardy (The University of Washington School of Pharmacy)
"Investigating Mechanisms of Lapatinib-induced Hepatotoxicity in Hepa RG Cells" |
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Upendra Dahal (Washington State University)
"Drug Metabolism by Cytochrome P450: Effects of Nitrogen - Iron Coordination on Affinity and Metabolic Stability"
|
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Diana Schuster (The University of Washington)
"Gene Expression Profiling of Maternal Liver, Kidney and Small Intestine in Pregnant Mice"
|
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Jamie D'Agostino (The University of Michigan)
"Mechanism - based Inactivation of Human Cytochrome P450 2B6 by Chlorpyrifos and Related Organophosphate Pesticides"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Yi Xiao (Vanderbilt School of Medicine)
"Cytochrome P450 2W1 Oxidizes both Lysophospholipids and Free Fatty Acids"
|
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Transporters: "Back to the Future" |
| Discussion Leader: John D. Schuetz (St. Jude Children's Research Hospital) |
9:00 am - 9:30 am | Robert Jansen (Netherlands Cancer Institute)
"Transportomics: Screening for Substrates of ABC Transporters in Body Fluids using Vesicular Transport Assays"
|
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Gerhard Ecker (University of Vienna)
"The Molecular Basis of Drug-Transporter Interaction- Science or Fiction"
|
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Irwin Arias (National Institutes of Health)
"Adventure in Liverland: The Role of Energy Metabolism in Polarized ABCB11 Trafficking in Hepatocytes"
|
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | John D. Schuetz (St. Jude Children's Research Hospital)
"The Metabolome Reveals Precursors of Cholestatic Injury"
|
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New Ideas and Technologies |
| Discussion Leader: Tom Rushmore (Thomas Jefferson University) |
7:30 pm - 8:00 pm | Rafel Witek (Life Technologies)
"Liver Cell Culture and Co-Culture Systems for More Relevant Modeling of Liver Physiology"
|
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Rick King (PharmaCadence)
"The Application of Leading Edge LC-MS Technology for the Quantitative Analysis of Enzyme, Substrate and Product from the Same Sample"
|
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Andrew Kasarskis (Mount Sinai School of Medicine)
"State of the Art and Applications of Modern Nucleic Acid Sequencing and Data Analysis Technologies"
|
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |