SUNDAY |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | The Many Faces of Drug Metabolism |
| Discussion Leader: James Mangold (Novartis) |
7:40 pm - 7:50 pm | James Mangold (Novartis)
"Introduction: The Many Faces of Drug Metabolism" |
7:50 pm - 9:00 pm | Keynote Lecture: Stephen Hecht (University of Minnesota)
"Metabolism, DNA Adduct Formation and Carcinogenicity of Tobacco-specific Nitrosamine Enantiomers" |
9:00 pm - 9:30 pm | Discussion |
MONDAY |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Applications of PK-PD and TK-TD Modeling in Drug Discovery and Development |
| Discussion Leader: Wade Adams (Metabolic Solutions Development Company) |
9:00 am - 9:45 am | Wade Adams (Metabolic Solutions Development Company)
"Prediction of Oxazolidinone Toxicity: A Retrospective" |
9:45 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:15 am | Harvey Wong (Genentech)
"From Mouse to Man and Back: Translational Pharmacokinetic-Pharmacodynamic Modeling in Oncology" |
11:15 am - 11:30 am | Discussion |
11:30 am - 12:15 pm | Wei-jian Pan (Amgen)
"Translational Pharmacology of AMG 181, a Human Anti-α4β7 Antibody Developed for Treating Inflammatory Bowel Diseases (IBD)" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Antibody-drug Conjugates |
| Discussion Leader: Jae Lee (Boehringer-Ingelheim) |
7:30 pm - 8:00 pm | Kedan Lin (Genentech)
"Exploring the Metabolism and Disposition of Antibody Drug" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Brooke VandenBrink (Amgen)
"The Impact of Linker Chemistry on the Activity of Antibody Drug Conjugates" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Steve Hansel (Pfizer)
"ADC Disposition: the Large and Small of It" |
9:20 pm - 9:30 pm | Discussion |
TUESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Conjugation Enzymes and In Vitro-In Vivo Correlations |
| Discussion Leader: Rory Remmel (University of Minnesota) |
9:00 am - 9:30 am | Ida Owens (National Institute of Child and Human Development, NIH)
"Endoplasmic reticulum-bound UDP-Glucuronosyltransferases Interact with Kinases in Order to Dictate Substrate Selections" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Nenad Menavski (University of Helsinki)
"The Albumin Effects on the Human UGTs are Enzyme and Substrate Dependent" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Charles Falany (University of Alabama)
"Substrate Selectivity and Inhibition in Cytosolic Sulfotransferases" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Rory Remmel (University of Minnesota)
"Atypical Kinetics of the UGT1A Enzymes" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Carcinogen Metabolism and Bioactivation |
| Discussion Leader: Lisa Peterson (University of Minnesota) |
7:30 pm - 8:00 pm | XinXin Ding (New York Department of Health)
"Role of Metabolism in Chemical Carcinogenesis - Insights from Transgenic Mouse Models" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Lisa Peterson (University of Minnesota)
"Bioactivation Pathways of Furan, a Possible Human Carcinogen" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Arthur Grollman (Stony Brook University)
"The bioactivation of aristolochic acid" |
9:20 pm - 9:30 pm | Discussion |
WEDNESDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | The Other Oxidases |
| Discussion Leader: Michael Zientek (Pfizer) |
9:00 am - 9:45 am | Matthew Hutzler (Boehringer-Ingelheim)
"Understanding Aldehyde Oxidase Metabolism: Species Differences and Variability in Activity" |
9:45 am - 10:00 am | Discussion |
10:00 am | Coffee Break |
10:30 am - 11:15 am | John Cashman (Human BioMolecular Research Institute)
"A Story of Flavin-containing Monooxygenase 3 in Humans: Hidden in Plain Sight" |
11:15 am - 11:30 am | Discussion |
11:30 am - 12:15 pm | Dale Edmondson (Emory University)
"Differential Structures and Functions of Human Mitochondrial MAO A and MAO B" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair |
7:30 pm - 9:30 pm | Graduate Student and Post-Doc Presentations |
| Discussion Leader: Henry Strobel (University of Texas - Houston Medical School) |
7:30 pm - 7:45 pm | Jason Baik (University of California - San Francisco)
"Simulating Drug Disposition Using Virtual Cell"
|
7:45 pm - 7:50 pm | Discussion |
7:50 pm - 8:05 pm | John Barr (Washington State University)
"Evaluation of Azathioprine and Other Nitro-group Containing Compounds as Time Dependent inhibitors of Human Liver Aldehyde Oxidase"
|
8:05 pm - 8:10 pm | Discussion |
8:10 pm - 8:25 pm | Ian Cook (Albert Einstein College of Medicine)
"Structure, Dynamics and Selectivity in the Cytosolic Sulfotransferase Family"
|
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:45 pm | Hong Lu (University of Rhode Island)
"Predicting Hepatic and Renal Clearance in Pediatric Populations Using Physiological and Biochemical Development Knowledge"
|
8:45 pm - 8:50 pm | Discussion |
8:50 pm - 9:05 pm | Ryan Seguin (University of Washington)
"Fluoroquinoline Metabolism Leads to Mechanism-based Inhibition of Cytochrome P450 1A2"
|
9:05 pm - 9:10 pm | Discussion |
9:10 pm - 9:25 pm | Kai Wang (Vanderbilt University)
"Reductive Detoxication of Carcinogenic Aromatic and Heterocyclic Aromatic Amines"
|
9:25 pm - 9:30 pm | Discussion |
THURSDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Drug Transporters: In"sights" Into Endogenous and Inflammatory Biomarkers |
| Discussion Leader: Imad Hanna (Novartis) |
9:00 am - 9:30 am | Daniel Bow (Abbvie Inc.)
"In Vivo Biomarkers of Drug Transporters" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Lauren Aleksunes (Rutgers University)
"Blood-Brain Barrier and Beyond: Efflux Transporter Regulation and Function During Neuroinflammation" |
10:15 am - 10:30 am | Discussion |
10:30 am | Coffee Break |
11:00 am - 11:30 am | Ryan Pelis (Dalhousie University)
"Renal organic anion transporter kinetics are influenced by aKG and NaDC3" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Manthena Varma (Pfizer)
"Mechanistic modeling of the transporter- and enzyme-mediated disposition and the complex drug interactions" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | New and Creative Applications of Technologies |
| Discussion Leader: Jimmy Flarakos (Novartis) |
7:30 pm - 8:00 pm | Gary Van Berkel (Oak Ridge National Laboratories)
"Laser Ablation and Liquid Extraction Surface Sampling Combinations for High Resolution Chemical Imaging of Drug Dosed Thin Tissue Sections" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:40 pm | Mohammad Ebrahimkhani (Massachusetts Institute of Technology)
"Human Body on a Chip" |
8:40 pm - 8:50 pm | Discussion |
8:50 pm - 9:20 pm | Thomas Covey (AB Sciex)
"Development of a Differential Mobility Device for Ultra High Sensitivity Biologics Assays and Surface Analysis" |
9:20 pm - 9:30 pm | Discussion |
FRIDAY |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |