Sunday |
2:00 pm - 9:00 pm | Arrival and Check-in |
6:00 pm | Dinner |
7:30 pm - 7:40 pm | Welcome / Introductory Comments by GRC Site Staff |
7:40 pm - 9:30 pm | Keynote Session: New Frontiers for DMPK in Precision Medicine |
| Discussion Leader: Kim Brouwer (University of North Carolina at Chapel Hill, USA) |
7:40 pm - 7:55 pm | Opening Remarks |
7:55 pm - 8:55 pm | Allan Rettie (University of Washington, USA) "Drug Metabolism Contributions to 'Precision Medicine': Past, Present, Future" |
8:55 pm - 9:30 pm | Discussion |
Monday |
7:30 am - 8:30 am | Breakfast |
8:30 am | Group Photo |
9:00 am - 12:30 pm | Advances in Precision Medicine: Endogenous Biomarkers |
| Discussion Leader: John Wagner (Takeda Pharmaceuticals, USA) |
9:00 am - 9:20 am | John Wagner (Takeda Pharmaceuticals, USA) "Advances in Precision Medicine: Why Do We Need a Multi-Stakeholder Process?" |
9:20 am - 9:30 am | Discussion |
9:30 am - 10:05 am | Shashi Amur (U.S. Food and Drug Administration, USA) "Biomarker Qualification: Toward a Multi-Stakeholder Framework for Biomarker Development, Regulatory Acceptance, and Utilization" |
10:05 am - 10:20 am | Discussion |
10:20 am - 10:50 am | Coffee Break |
10:50 am - 11:25 am | Rima Kaddurah-Daouk (Duke University Health System, USA) "Metabolomic Signatures for Drug Response Phenotypes-Pharmacometabolomics Enables Precision Medicine" |
11:25 am - 11:40 am | Discussion |
11:40 am - 12:15 pm | Frank Sistare (Merck & Co., Inc., USA) "Identification, Application, and Regulatory
Qualification of New Translational Biomarkers for Improved Safety Assessment in
Drug Development" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Clinical and Real World Applications of Precision Medicine |
| Discussion Leader: Rebecca Blanchard (Merck & Co., Inc., USA) |
7:30 pm - 7:40 pm | Introduction by Discussion Leader |
7:40 pm - 8:00 pm | Dermot Reilly (Merck Research Laboratories, USA) "Association Analysis of Low Frequency Genetic Variation with Liver Triglyceride Content and Related Endpoints in a Multi-Ethnic Cohort" |
8:00 pm - 8:10 pm | Discussion |
8:10 pm - 8:30 pm | Sara Van Driest (Vanderbilt University, USA) "The Electronic Medical Record as a Tool for
Precision Medicine Research and Implementation" |
8:30 pm - 8:40 pm | Discussion |
8:40 pm - 9:00 pm | Cliona Molony (Pfizer, USA) "Mining Real-World Data for Precision Medicine in Drug Discovery" |
9:00 pm - 9:10 pm | Discussion |
9:10 pm - 9:30 pm | General Discussion |
Tuesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Orphan P450s: Discovery of Function and Relevance to Applications in Medicine |
| Discussion Leader: F. Peter Guengerich (Vanderbilt University School of Medicine, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | F. Peter Guengerich (Vanderbilt University School of Medicine, USA) "The General Problem of Gene Annotation and Its Significance with P450s: Deorphanization of Several Human P450s" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Edward Kelly (University of Washington, USA) "P450 4V2 and Its Role in Vision" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Kevin Johnson (Vanderbilt University School of Medicine, USA) "CYP27C1 Catalyzes the Desaturation of Vitamin A1 to Vitamin A2" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | John Stegeman (Woods Hole Oceanographic Institution, USA) "Use of Fish Models in Deorphanization of P450s" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Targeted Covalent Inhibitors – Risks, Benefits, and Promise for Precision Medicine |
| Discussion Leader: Thomas Baillie (University of Washington, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Thomas Baillie (University of Washington, USA) "Reversible and Irreversible Covalent Drugs for Precision Medicine – Therapeutic Promise Versus Toxicological Risk" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Deqiang Niu (Celgene Avilomics Research, USA) "The Discovery of Rociletinib (CO-1686): An Example of Engineering Selectivity into EGFR Covalent Inhibitors" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | John Kath (Pfizer Global Research and Development, USA) "Reducing Proteome Reactivity of Irreversible EGFR T790M Inhibitors" |
9:15 pm - 9:30 pm | Discussion |
Wednesday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | Transporters: To Precision and Beyond |
| Discussion Leader: Sonia de Morais (AbbVie Inc., USA) |
9:00 am - 9:10 am | Introduction by Discussion Leader |
9:10 am - 9:40 am | Allan Wolkoff (Jack and Pearl Resnick Campus, Albert Einstein College of Medicine, USA) "Intracellular Trafficking of Drug Transporters" |
9:40 am - 9:55 am | Discussion |
9:55 am - 10:20 am | Bo Feng (Pfizer, USA) "Predicting Human Brain Penetration from In Vitro Transporter Studies" |
10:20 am - 10:35 am | Discussion |
10:35 am - 11:05 am | Coffee Break |
11:05 am - 11:30 am | Aleksandra Galetin (University of Manchester, United Kingdom) "PBPK for Drug Transporters - What Is Missing?" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Kathleen Giacomini (University of California, San Francisco, USA) "Clinical Relevance of Drug Transporters – Enabling Precision Medicine" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:00 pm - 7:30 pm | Business Meeting |
| Nominations for the Next Vice Chair; Fill in Conference Evaluation Forms; Discuss Future Site and Scheduling Preferences; Election of the Next Vice Chair |
7:30 pm - 9:30 pm | Young Investigator Presentations |
| Session in honor of Dr. Richard Okita. |
| Discussion Leader: Henry Strobel (University of Texas Medical School at Houston, USA) |
7:30 pm - 7:45 pm | Introduction by Discussion Leader |
7:45 pm - 7:55 pm | Izna Ali (University of North Carolina at Chapel Hill, USA) "Identification of Novel MRP3 Inhibitors Based on Computational Models and Verification Using an In Vitro Membrane Vesicle Assay" |
7:55 pm - 8:00 pm | Discussion |
8:00 pm - 8:10 pm | Sara Humphreys (Washington State University, USA) "Novel Time-Resolved Three-Dimensional Approach to Quantify Passive Diffusion Rates of Drug-Like Compounds Across MDCK Monolayers at Sub-Cellular Resolution" |
8:10 pm - 8:15 pm | Discussion |
8:15 pm - 8:25 pm | Erkka Järvinen (University of Helsinki, Finland) "MRP3 Is More Efficient than MRP2 in Transporting Small Bicyclic Planar Glucuronides" |
8:25 pm - 8:30 pm | Discussion |
8:30 pm - 8:40 pm | Bryan Mackowiak (University of Maryland School of Pharmacy, USA) "Prototypical CAR Antagonist PK11195 Is Metabolized to a CAR Activator in Physiologically-Relevant Cellular Systems" |
8:40 pm - 8:45 pm | Discussion |
8:45 pm - 8:55 pm | Ting Wang (Albert Einstein College of Medicine, USA) "Isozyme Specific Allosteric Regulation of Human Sulfotransferase 1A1 – Structure and Mechanism" |
8:55 pm - 9:00 pm | Discussion |
9:00 pm - 9:10 pm | Dahea You (Rutgers University, USA) "Enhanced Histone Acetylation Up-Regulates MDR1 and BCRP Transporters in Human Blood-Brain Barrier Cells" |
9:10 pm - 9:15 pm | Discussion |
9:15 pm - 9:30 pm | General Discussion |
Thursday |
7:30 am - 8:30 am | Breakfast |
9:00 am - 12:30 pm | New Frontiers for Predicting Renal Toxicity and Clearance, and Applications in Precision Medicine |
| Discussion Leader: Deanna Kroetz (University of California, San Francisco, USA) |
9:00 am - 9:05 am | Introduction by Discussion Leader |
9:05 am - 9:30 am | Deanna Kroetz (University of California, San Francisco, USA) "Prediction of Renal Drug Clearance and Toxicity with a Biomimetic Microfluidics Platform" |
9:30 am - 9:45 am | Discussion |
9:45 am - 10:15 am | Benjamin Freedman (University of Washington, USA) "iPSC-Derived Human Kidney Organoids: Platforms for Disease Modeling and Therapeutics Testing" |
10:15 am - 10:30 am | Discussion |
10:30 am - 11:00 am | Coffee Break |
11:00 am - 11:30 am | Vishal Vaidya (Harvard Medical School, USA) "Early Biomarkers of Human Renal Injury" |
11:30 am - 11:45 am | Discussion |
11:45 am - 12:15 pm | Adrian Ray (Gilead Sciences, Inc., USA) "Improved Prediction of Renal Drug-Drug Interactions" |
12:15 pm - 12:30 pm | Discussion |
12:30 pm | Lunch |
1:30 pm - 4:00 pm | Free Time |
4:00 pm - 6:00 pm | Poster Session |
6:00 pm | Dinner |
7:30 pm - 9:30 pm | Precision Medicine: Why It Works, Why It Has
Not Worked, and Strategies to Overcome Barriers |
| Discussion Leader: Bob Powell (UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA) |
7:30 pm - 7:35 pm | Introduction by Discussion Leader |
7:35 pm - 7:55 pm | Bob Powell (UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, USA) "Precision Medicine: Why It Works, Why It Has Not
Worked, and Strategies to Overcome Barriers - Principles and Case Studies" |
7:55 pm - 8:10 pm | Discussion |
8:10 pm - 8:35 pm | Richard Peck (F. Hoffmann La Roche, Switzerland) "Precision
Medicine: Successes, Challenges Opportunities, Ideas - A Personal
Perspective (from Someone in Industry)" |
8:35 pm - 8:50 pm | Discussion |
8:50 pm - 9:15 pm | Yaning Wang (U.S. Food and Drug Administration, USA) "Precision Medicine: Mission of FDA Clinical
Pharmacology" |
9:15 pm - 9:30 pm | Discussion |
Friday |
7:30 am - 8:30 am | Breakfast |
9:00 am | Departure |