Drug Discovery to Precision Therapeutics: Novel Mechanisms, Models and Technologies

The 50th Gordon Research Conference on Drug Metabolism will approach ADME (absorption, distribution, metabolism, elimination) science from a perspective that focuses on patients as unique individuals, in contrast to the more traditional "population" perspective, as a preparatory step to delivering precision therapeutics. For example, the questions that most concern the pharmaceutical industry and regulatory agencies tend to be compound-specific (Will this compound be effective? Will this compound be safe?), leading to dosing recommendations that, on average, are safe and effective for the patient population to be treated. Unfortunately, many individuals possess characteristics that make them unique, and delivery of precision therapeutics requires identification and integration of patient-specific information into dosing algorithms. In its celebration of 50 years of progress in ADME research, the 2022 Gordon Research Conference on Drug Metabolism will focus on the presentation of unpublished, cutting edge research in a wide range of topics. It is notable that several topics discussed at the first Drug Metabolism GRC, such as drug metabolism by intestinal micro-organisms, prediction of in vivo drug metabolism from in vitro studies, mechanisms of drug metabolism and new in vitro technologies to advance drug metabolism remain highly relevant issues today; each will be addressed from a 21st century perspective. The program will also include areas of research yet to be conceived in 1971, such as the complexity of influx and efflux transporters, non-small molecule therapeutics and technological tools such as mass spectrometry.

Attendees are encouraged to submit posters for display at the poster sessions organized by the Vice Chair Dr. Jane R. Kenny. The Wednesday evening session will feature oral presentations by young investigators (graduate students, postdoctoral trainees and early career investigators) selected from the submitted poster abstracts. The conference is collegial and informal in nature, with ample opportunity to discuss unpublished research, establish collaborative relationships, and develop new ideas. Young investigators have easy access to mentoring from established investigators, as well as during informal career advice discussions planned during the week. Additional activities include a Power Hour, and a special session that celebrates breakthroughs in drug metabolism and the learning opportunities they provide to trainees and young investigators. Attendees are encouraged to bring their vision for what the drug metabolism field will look like 50 years from now and any other items they would like to include in a time capsule for the 100th Drug Metabolism GRC.

The registration fee includes all meals and housing on the Holderness School campus. In addition to the scientific sessions, attendees are encouraged to enjoy the many outdoor recreational activities in the area. Afternoon traditions of this conference include an Academia vs. Industry softball game (no experience necessary, bring your gloves!), and hiking and kayaking/canoeing outings in the White Mountains.