Sunday
2:00 pm - 9:00 pm
Arrival and Check-in
6:00 pm - 7:00 pm
Dinner
7:30 pm - 7:40 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
7:40 pm - 9:30 pm
Keynote Session: Drug Metabolism in the Multiverse of Discovery
7:40 pm - 7:55 pm
Opening Remarks
7:55 pm - 8:00 pm
Introduction by Discussion Leader
8:00 pm - 9:00 pm
"New Lessons from The Biotransformation and Distribution of ADCs, PROTACs, and Small Molecules"
9:00 pm - 9:30 pm
Discussion
Monday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Group Photo
9:00 am - 12:30 pm
Targeted Protein Degraders: ADME Challenges and Overcoming the Oral Dilemma
9:00 am - 9:30 am
"Addressing PROTAC ADME Challenges"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Innovative Approaches to Understanding PROTAC Oral Absorption"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Mechanistic PKPD Modeling for TPD: Insights for Compound Prioritization and Strategies for Translation"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Long Acting Injectable Formulation as a Drug Delivery Platform for Protein Degrader"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
3:00 pm - 4:00 pm
The GRC Power Hourâ„¢
The GRC Power Hourâ„¢ is designed to address diversity and inclusion in the scientific workplace by providing a safe environment for informal and meaningful conversations amongst colleagues of all career stages. The program supports the professional growth of all members of our communities, including ethnicity, race and/or gender identity by providing an open forum for discussion and mentoring.
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Novel Mechanisms and Methods to Predict Drug Interactions
7:30 pm - 7:55 pm
"Use of Modeling Approaches for Evaluating Time Dependent Inhibition Mediated Drug-Drug Interactions"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Getting it Right: How In Vitro Conditions Alter CYP Inhibition"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Improving Drug-Drug Interaction Predictions for Renal OCT2 and MATE1/2-K Transporters: Impact of Inhibitor Intracellular Accessibility and Flux Studies in a Double Transfection System"
9:15 pm - 9:30 pm
Discussion
Tuesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Approaches, Interpretations, and Applications of Fraction Unbound
9:00 am - 9:30 am
"Impact of Plasma Protein Binding on Pharmacokinetics and Drug-Drug Interaction"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Experimental and Kinetic Considerations for Interpreting Drug Unbound Fraction: Free Drug Hypothesis Implications and Caveats"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Does Albumin Facilitate Transporter-Mediated Uptake Clearance of OATP Drugs?"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Fraction Unbound Assessment in Xenografted Tumors: Challenges and Strategies"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Sex, Gender, and ADME Science
7:30 pm - 7:55 pm
"PBPK Models of the Female Reproductive Tract: Prediction of Plasma and Local Tissue Concentrations After Drug Administration"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Hormones, Microbes, and Drugs in the Female Genital Tract: Models to Address the Enigma"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Applying Clinical Pharmacology to Transgender Medicine"
9:15 pm - 9:30 pm
Discussion
Wednesday
7:30 am - 8:30 am
Breakfast
9:00 am - 12:30 pm
Novel Technologies for Translational DMPK
9:00 am - 9:30 am
"Microphysiological Systems: Complex In Vitro Platforms for Safety, Efficacy and Disease Models for Precision Medicine"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Developing an Adult Stem Cell Derived Micro Physiological System of Intestine for Predicting Oral Prodrug Bioconversion and Permeability in Humans"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Normal and Diseased Engineered Liver Platforms for Investigating Drug Disposition"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"From Molecules to Visuals: Empowering Drug Discovery and Development with Mass Spectrometry Imaging"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Early-Career Investigator Presentations
7:30 pm - 7:45 pm
"THC and CBD Acyl Glucuronides are Formed by Different UGT Enzymes and Show Different Migration Rates"
7:45 pm - 7:50 pm
Discussion
7:50 pm - 8:05 pm
"Interindividual Variability In Sulfamethoxazole Metabolism In Primary Human Hepatocytes"
8:05 pm - 8:10 pm
Discussion
8:10 pm - 8:25 pm
"Quantification of Drug-Metabolising Enzymes and Transporters in Polycystic Kidney Disease"
8:25 pm - 8:30 pm
Discussion
8:30 pm - 8:45 pm
"Use of In Vitro and In Vivo Studies Together with PBPK Modeling to Understand Cortisol Kidney Disposition and Signaling"
8:45 pm - 8:50 pm
Discussion
8:50 pm - 9:05 pm
"Assessment of Cross-Platform Concordance of PBPK Model Performance Using Isoniazid as a Case Study"
9:05 pm - 9:10 pm
Discussion
9:10 pm - 9:25 pm
"Hemp vs. CBD: The Potency of the Whole Is Not Greater Than the Sum of Its Parts"
9:25 pm - 9:30 pm
Discussion
Thursday
7:30 am - 8:30 am
Breakfast
8:30 am - 9:00 am
Business Meeting
Nominations for the Next Vice Chair(s); Complete the GRC Evaluation Forms; Election of the Next Vice Chair(s)
9:00 am - 12:30 pm
Structures and Mechanisms of Metabolizing Enzymes and Transporters
9:00 am - 9:30 am
"Adrenoxin Interactions with Human Cytchrome P450 27A1"
9:30 am - 9:45 am
Discussion
9:45 am - 10:15 am
"Fun with Fluorine: Following and Fiddling with Drug/Protein Complex Formation"
10:15 am - 10:30 am
Discussion
10:30 am - 11:00 am
Coffee Break
11:00 am - 11:30 am
"Structural Biology of Human CYP2C9 and CYP2C8: Impact of Genetic Polymorphisms and Ligand Binding"
11:30 am - 11:45 am
Discussion
11:45 am - 12:15 pm
"Structure of the Plasmodium Falciparum NCR1 Transporter"
12:15 pm - 12:30 pm
Discussion
12:30 pm - 1:30 pm
Lunch
1:30 pm - 4:00 pm
Free Time
4:00 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Tracking Missing Metabolites
7:30 pm - 7:55 pm
"Missing Metabolites Implicated in Drug-Induced Liver Injury"
7:55 pm - 8:10 pm
Discussion
8:10 pm - 8:35 pm
"Radiolabel to Uncover "Missing" Metabolites of Candidate Drugs"
8:35 pm - 8:50 pm
Discussion
8:50 pm - 9:15 pm
"Understanding Missing Metabolites in Drug Metabolism by Unlocking Complexity"
9:15 pm - 9:30 pm
Discussion
Friday
7:30 am - 8:30 am
Breakfast
9:00 am
Departure