Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Finding Catalysts of Gut Reactions: The Gut Microbiota in Disease Onset and Treatment
Discussion Leaders: Alexander Byer-Alcorace (Boehringer Ingelheim Pharmaceuticals, United States)
3:45 pm - 4:15 pm
Elizabeth Bess (University of California, Irvine, United States)
"Finding Catalysts of Gut Reactions: The Gut Microbiota in Disease Onset and Treatment"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Models to Predict Variability in Drug Disposition and Response
Discussion Leaders: Annamarie Bustion (UCSF / Gladstone Institutes, United States)
7:30 pm - 7:50 pm
Raaj Mehta (Massachusetts General Hospital & Harvard Medical School, United States)
"Gut Microbial Metabolism of 5-ASA Diminishes Its Clinical Efficacy in IBD"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
Jessica Beers (University of North Carolina at Chapel Hill, United States)
"Understanding Cannabidiol-Induced Liver Injury using a Three-Dimensional Human Hepatocyte Spheroid Model"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
Tirtha Nandi (Temple University, United States)
"Inclusion of Intestinal Metabolism in a Continuous Intestinal Absorption Model to Predict Clinical Pharmacokinetics of Oral Midazolam and Nicardipine"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
Deepak Ahire (Washington State University, United States)
"Role of UGT2B17 in the Metabolism of Prescription Drugs and Steroids is Underappreciated"
9:20 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Mapping out Transporters and Identifying Substrates
Discussion Leaders: Erickson Paragas (Amgen, United States) and Cody Thomas (Boehringer Ingelheim Pharmaceuticals, Inc., United States)
9:00 am - 9:20 am
William Murphy (University of North Carolina at Chapel Hill, United States)
"Cellular Localization and Zonal Quantification of Hepatic Bile Acid Transporters BSEP and NTCP: Novel Machine Learning Approach to Elucidate Alterations in Nonalcoholic Fatty Liver Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
Aditya Kumar (University of Washington, United States)
"Mechanisms of Transplacental Transfer of (-)-?9-Tetrahydrocannabinol (THC) in the Human Dual Cotyledon, Dual Perfusion, Placenta Model"
9:50 am - 10:00 am
Discussion
10:00 am - 11:00 am
Panel Discussion
Mentorship
Jane Kenny (Genentech, United States)
Elizabeth Bess (University of California, Irvine, United States)
J. Steven Leeder (Children's Mercy Hospital, United States)
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Models and Technologies to Predict Drug Disposition
Discussion Leader: Abhinav Sharma (AbbVie Inc., United States)
1:30 pm - 1:45 pm
Wilma Kiander (University of Helsinki, Finland)
"In Vitro Characterization of SLCO1B1 Variants and Simulation of Clinical Pharmacokinetic Impact"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
Yifan Gong (School of Pharmacy, Temple University, United States)
"Can the Glycocalyx Impact Partitioning of Drugs into Red Blood Cells?"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
Than Kyaw (University of California, San Francisco, United States)
"Gut Bacterial P-Glycoprotein Inhibitors Boost the Absorption of Orally Administered Drugs"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes
