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Drug Metabolism (GRS)

Gordon Research Seminar

Translational Models and Technologies to Predict Drug Disposition and Response

July 9 - 10, 2022
Chair
Holderness School
33 Chapel Lane
Holderness, New Hampshire, United States
 Venue and Travel Information

Conference Description

The Gordon Research Seminar on Drug Metabolism is a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education to present and exchange new data and cutting edge ideas.

The inaugural GRS in drug metabolism will focus on non-traditional and improved models, technologies, and techniques that can help in predicting pharmacokinetics and pharmacodynamics that traditional methods have yet to capture. Oral presentations delivered by graduate students and post-docs will be selected from submitted abstracts. The GRS will also include a mentorship panel represented by early stage and established career scientists in academia and industry.

Related Meeting

This GRS will be held in conjunction with the "Drug Metabolism" Gordon Research Conference (GRC). Those interested in attending both meetings must submit an application for the GRC in addition to an application for the GRS. Refer to the associated GRC program page for more information.

Conference Program

Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Site Staff / Welcome from the GRS Chair
3:45 pm - 4:30 pm
Keynote Session: Finding Catalysts of Gut Reactions: The Gut Microbiota in Disease Onset and Treatment
Discussion Leaders:
3:45 pm - 4:15 pm
"Finding Catalysts of Gut Reactions: The Gut Microbiota in Disease Onset and Treatment"
4:15 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Models to Predict Variability in Drug Disposition and Response
Discussion Leaders:
7:30 pm - 7:50 pm
"Gut Microbial Metabolism of 5-ASA Diminishes Its Clinical Efficacy in IBD"
7:50 pm - 8:00 pm
Discussion
8:00 pm - 8:20 pm
"Understanding Cannabidiol-Induced Liver Injury using a Three-Dimensional Human Hepatocyte Spheroid Model"
8:20 pm - 8:30 pm
Discussion
8:30 pm - 8:50 pm
"Inclusion of Intestinal Metabolism in a Continuous Intestinal Absorption Model to Predict Clinical Pharmacokinetics of Oral Midazolam and Nicardipine"
8:50 pm - 9:00 pm
Discussion
9:00 pm - 9:20 pm
"Role of UGT2B17 in the Metabolism of Prescription Drugs and Steroids is Underappreciated"
9:20 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Mapping out Transporters and Identifying Substrates
Discussion Leaders: and
9:00 am - 9:20 am
"Cellular Localization and Zonal Quantification of Hepatic Bile Acid Transporters BSEP and NTCP: Novel Machine Learning Approach to Elucidate Alterations in Nonalcoholic Fatty Liver Disease"
9:20 am - 9:30 am
Discussion
9:30 am - 9:50 am
"Mechanisms of Transplacental Transfer of (-)-?9-Tetrahydrocannabinol (THC) in the Human Dual Cotyledon, Dual Perfusion, Placenta Model"
9:50 am - 10:00 am
Discussion
10:00 am - 11:00 am
Panel Discussion
Mentorship
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Models and Technologies to Predict Drug Disposition
Discussion Leader:
1:30 pm - 1:45 pm
"In Vitro Characterization of SLCO1B1 Variants and Simulation of Clinical Pharmacokinetic Impact"
1:45 pm - 1:50 pm
Discussion
1:50 pm - 2:05 pm
"Can the Glycocalyx Impact Partitioning of Drugs into Red Blood Cells?"
2:05 pm - 2:10 pm
Discussion
2:10 pm - 2:25 pm
"Gut Bacterial P-Glycoprotein Inhibitors Boost the Absorption of Orally Administered Drugs"
2:25 pm - 2:30 pm
Discussion
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes

Contributors

Research reported in this publication was supported by the National Center For Advancing Translational Sciences of the National Institutes of Health under Award Number R13TR003470. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.

Conference Links

Conference History Drug Metabolism
Additional Fee Info

Drug Metabolism
July 6 - 11, 2025


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