Saturday
1:00 pm - 5:00 pm
Arrival and Check-in
3:30 pm - 3:45 pm
Introductory Comments by GRC Staff / Welcome and Introduction from the Chairs
3:45 pm - 4:30 pm
Navigating The Diverse Landscape of Drug Therapeutics
3:45 pm - 4:05 pm
"Assays And Mechanisms To Define Target Independent Clearance Of Therapeutic Antibodies"
4:05 pm - 4:10 pm
Discussion
4:10 pm - 4:25 pm
"Cytochrome P450 3A7 Structure Reveals Four Binding Sites For Its Native Substrate Dehydroepiandrosterone Sulfate (DHEA-S)"
4:25 pm - 4:30 pm
Discussion
4:30 pm - 6:00 pm
Poster Session
6:00 pm - 7:00 pm
Dinner
7:30 pm - 9:30 pm
Perspectives and Challenges in In vitro- In vivo ADME
7:30 pm - 7:50 pm
"Predictive Pharmacokinetics of Drug Delivery Systems: Are We There Yet?"
7:50 pm - 7:55 pm
Discussion
7:55 pm - 8:10 pm
"Intestinal Tissue Organoids To Study Drug Transport And Metabolism From Infants To Adults"
8:10 pm - 8:15 pm
Discussion
8:15 pm - 8:30 pm
"Prediction and Validation of Fetal Exposure to Dual BRPR/P-gp Drug Substrates Using the Proteomics Informed Relative Expression Factor (ER-REF) approach and PBPK modeling and Simulation"
8:30 pm - 8:35 pm
Discussion
8:35 pm - 8:50 pm
"Systemic and CNS Distributional Pharmacokinetics of WSD0628, A Novel Radiosensitizer for The Treatment of Brain Tumors"
8:50 pm - 8:55 pm
Discussion
8:55 pm - 9:10 pm
"In Silico Modelling of Transmucosal Drug Delivery Informed by In Vitro Approaches"
9:10 pm - 9:15 pm
Discussion
9:15 pm - 9:25 pm
"Implications of pH-Dependent Non-Specific Interactions on The Cellular Disposition of Monoclonal Antibodies"
9:25 pm - 9:30 pm
Discussion
Sunday
7:30 am - 8:30 am
Breakfast
9:00 am - 11:00 am
Methods And Techniques In Addressing Challenges In Translating In vitro-In vivo ADME
9:00 am - 9:20 am
"Transport Of Secondary Bile Acid Metabolites And Their Putative Role On Non-Alcoholic Fatty Liver Disease (NAFLD) Pathogenesis"
9:20 am - 9:25 am
Discussion
9:25 am - 9:35 am
"Using Net Clearances to Simulate Drug Permeation Across MDCK Cells"
9:35 am - 9:40 am
Discussion
9:40 am - 9:50 am
"Characterization of a Human Liver Organoid Model: Transport Protein Expression, Localization, Function, and Regulation"
9:50 am - 9:55 am
Discussion
9:55 am - 10:15 am
"Understanding Drug Metabolism, Disposition, And Response Using Mass Spectrometry Imaging"
10:15 am - 10:20 am
Discussion
10:20 am - 10:35 am
"Prediction And Validation Of Human Hepatobiliary Clearances And Hepatic Concentrations Of Transported Drugs, Pitavastatin, And Glyburide Using The REF And PET Imaging Approaches"
10:35 am - 10:40 am
Discussion
10:40 am - 10:55 am
"How Much is Enough? BI-907828: A MDM2-p53 Antagonist With Limited BBB Penetration But Potent Efficacy in Glioblastoma"
10:55 am - 11:00 am
Discussion
11:00 am - 12:30 pm
Poster Session
Coffee will be served in the poster area from 11:00 am - 11:30 am
12:30 pm - 1:30 pm
Lunch
1:30 pm - 2:30 pm
Mentorship Component: Defining A Career Path In Drug Metabolism And Pharmacokinetics Research
1:30 pm - 2:30 pm
Panel Discussion
Promoting Career Growth
2:30 pm - 3:00 pm
Evaluation Period
Complete the GRS Evaluation Forms; Election of Future Chair(s)
3:00 pm
Seminar Concludes