| SUNDAY |
| 2:00 pm - 11:00 pm | Arrival and Check-in |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | INTRODUCTION AND KEYNOTE ADDRESS |
| 7:30 pm - 8:00 pm | Joe G.N. Garcia (University of Chicago, Chicago, Illinois, USA) |
| 8:00 pm - 9:00 pm | Keynote Speaker: Jordon Pober (Yale University, New Haven, CT USA)
"Endothelial cells as participants in the adaptive immune response" |
| MONDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am | Group Photo |
| 9:00 am - 12:30 pm | OUTSIDE-THE-BOX PERSPECTIVES |
| 9:00 am - 9:05 am | Discussion Leader: William Aird (Harvard Medical School, Boston, MA USA) |
| 9:05 am - 9:30 am | Jane Maienschein (Arizona State University, Tempe, AZ, USA)
"Who discovered (or invented?) the endothelium?" |
| 9:30 am - 9:50 am | Discussion |
| 9:50 am - 10:15 am | Ugur Ozerdem (La Jolla Institute for Molecular Medicine, San Diego, CA, USA)
"An out-of-box approach: Inhibiting pericytes to improve drug delivery across capillary wall" |
| 10:15 am - 10:35 am | Discussion |
| 10:35 am - 11:00 am | Coffee Break |
| 11:00 am - 11:25 am | Ralph Purdy (UC Irvine, Irvine CA, USA)
"Effects of microgravity on endothelium and nitric oxide synthases" |
| 11:25 am - 11:45 am | Discussion |
| 11:45 am - 12:10 am | George Mensah (Centers for Disease Control and Prevention, Atlanta, USA)
"Hygeia, Panacea, and the Deacon’s Masterpiece: The Endothelium as integrating denominator in disease prevention and control" |
| 12:10 am - 12:30 am | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | THE MOBILE ENDOTHELIUM |
| 7:30 pm - 7:35 pm | Discussion Leader: Elisabetta Dejana (Firc Institute of Molecular Biology) |
| 7:35 pm - 7:55 pm | Shahin Rafii (Cornell University Medical College, New York, NY USA)
"Contribution of pro-angiogenic hematopoietic cells to revascularization" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:25 pm | Catherine Verfaille (University of Minnesota, Minneapolis MN, USA)
"Different endothelia from MAPCs" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:55 pm | Mervin Yoder (Indiana University, Indianapolis, IN, USA)
"Defining human endothelial progenitor cells" |
| 8:55 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:25 pm | Rob Simari (Mayo Clinic, Rochester Minnesota USA)
"Diagnostic & Therapeutic uses of circulation-derived endothelial cells" |
| 9:25 pm - 9:30 pm | Discussion
|
| TUESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | BEYOND ANGIOGENESIS- VEGF AND THE ENDOTHELIUM |
| 9:00 am - 9:05 am | Discussion Leader: Hal Dvorak (Harvard University, Boston, MA, USA) |
| 9:05 am - 9:25 am | Hellmut Augustin (Germany)
"Emerging roles of EC RTKs in the regulation of vascular quiescence, homeostasis, and cell trafficking" |
| 9:25 am - 9:35 am | Discussion |
| 9:35 am - 9:55 am | Susan Quaggin (University of Toronto, Toronto, CANADA)
"Podocyte-endothelial interactions and angiogenic factors in glomerular development and disease" |
| 9:55 am - 10:05 am | Discussion |
| 10:05 am - 10:25 am | Norbert Voelkel (University of Colorado, Denver, CO USA)
"The role of the endothelium in severe pulmonary hypertension-a life-threatening disease" |
| 10:25 am - 10:35 am | Discussion |
| 10:35 am | Coffee Break |
| 11:00 am - 11:20 am | Young Kwon Hong (University of Southern California)
"Molecular controls of physiological and pathological lymphangiogenesis" |
| 11:20 am - 11:30 am | Discussion |
| 11:30 am - 11:50 am | Jan Kitajewski (Columbia University, New York City, NY, USA)
"Notch signaling in endothelial cells" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Two Presentations from Selected Submitted Abstracts:
Massimo M. Santoro "A specific role for BIRC2 and TNF/NF-KB signaling in vascular development"
Shiladitya Sengupta "Glycome regulation of endothelial phenotype"
|
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | RAGE AND THE HETERGENEOUS ENDOTHELIUM |
| 7:30 pm - 7:35 pm | Discussion Leader: David Stern (University of Cincinnatti, Cincinnatti, OH, USA) |
| 7:35 pm - 7:55 pm | Wen-Cheng Xiong (Medical College of Georgia, USA)
"RAGE regulation of osteoclast maturation and Function: Implications in endothelial cells?" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:25 pm | Hiroshi Yamamoto (Kanazawa University, Japan)
"RAGE and Diabetic Nephropathy" |
| 8:25 pm - 8:35 pm | Discussion
|
| 8:35 pm - 8:55 pm | Ed Conway (University of Leuvens, Belgium)
"The many faces of thrombomodulin" |
| 8:55 pm - 9:05 pm | Discussion
|
| 9:05 pm - 9:25 pm | Christine Metz (Feinstein Institute for Medical Research, Manhasset, NY)
"Cholinergic stimulation of endothelial cells during inflammation" |
| 9:25 pm - 9:30 pm | Discussion |
| WEDNESDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am - 12:30 pm | CONGENITAL ABNORMALITIES AND THE HETEROGENEOUS ENDOTHELIUM |
| 9:00 am - 9:05 am | Discussion Leader: Thomas Daniel MD (Ambrx, San Diego, CA, USA) |
| 9:05 am - 9:25 am | Mikka Vikkula (Brussels)
"Genetic defects causing localized vascular anomalies in man" |
| 9:25 am - 9:35 am | Discussion
|
| 9:35 am - 9:55 am | Dean Li (University of Utah, Salt Lake City, UT, USA)
"Vascular guidance cues in development and disease" |
| 9:55 am - 10:05 am | Discussion |
| 10:05 am - 10:25 am | Michelle Letarte (University of Toronto, CANADA)
"Insights into endothelial cell function from the study of Hereditary Hemorrhagic Telangiectasia" |
| 10:25 am - 10:35 am | Discussion
|
| 10:35 am | Coffee Break |
| 11:00 am - 11:20 am | Christer Betsholtz (Karolinska)
"Cell-cell interactions in angiogenesis" |
| 11:20 am - 11:30 am | Discussion
|
| 11:30 am - 11:50 am | Anne Eichmann (INSERM - Paris, FRANCE)
"The UNC5B receptor for the axon guidance cue netrin in angiogenesis" |
| 11:50 am - 12:00 pm | Discussion |
| 12:00 pm - 12:20 pm | Michael Klagsbrun (Harvard University, Boston, MA, USA)
"Semaphorins and Neuropilins in angiogenesis and cancer" |
| 12:20 pm - 12:30 pm | Discussion |
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ORGANOTYPIC ENDOTHELIUM IN DISEASE |
| 7:30 pm - 7:35 pm | Discussion Leader: Barbara Ballermann (Edmonton- TGF HHT) |
| 7:35 pm - 7:55 pm | Napoleone Ferrara (Genentech, San Francisco, CA USA)
"Organ-specific regulation of angiogenesis" |
| 7:55 pm - 8:05 pm | Discussion |
| 8:05 pm - 8:25 pm | Didier Stainier (UCSF)
"Endothelial cell differentiation and morphogenesis in Zebrafish" |
| 8:25 pm - 8:35 pm | Discussion |
| 8:35 pm - 8:55 pm | Eckhard Lammert (Max Plank)
"The Vascular niche of pancreatic islets" |
| 8:55 pm - 9:05 pm | Discussion |
| 9:05 pm - 9:25 pm | Ondine Cleaver (UT Southwestern Dallas, USA)
"Specification during blood vessel development and organogenesis" |
| 9:25 pm - 9:30 pm | Discussion |
| THURSDAY |
| 7:30 am - 8:30 am | Breakfast |
| 8:30 am - 9:00 am | Business Meeting |
| (Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site & Scheduling preferences; Election of the next Vice Chair) |
| 9:00 am - 12:30 am | HETEROGENEITY IN PERMEABILITY OF THE ENDOTHELIUM |
| 9:00 am - 9:05 am | Discussion Leader: Troy Stevens (University of South Alabama, AL USA) |
| 9:05 am - 9:25 am | Elizabetta Dejana (University of Milan, Milan, Italy)
"Signaling through intercellular junctions and endothelial cell phenotype" |
| 9:25 am - 9:35 am | Discussion
|
| 9:35 am - 9:55 am | Tanya N Mayadas (Harvard Medical School, Boston, MA USA)
"Epac1 regulation of vascular permeability" |
| 9:55 am - 10:05 am | Discussion |
| 10:05 am-10:25 am | Tim Hla (University of Connecticut, Hartford, CT, USA)
"Sphingosine 1-phosphate gradient and the vasculature" |
| 10:25 am - 10:35 am | Discussion
|
| 10:35 am - 11:00 am | Coffee Break |
| 11:00 am - 11:20 am | Sarah Yuan (University of California Davis, USA)
"Focal adhesion and junctional integrity in coronary microvascular barrier regulation" |
| 11:20 am - 11:30 am | Discussion
|
| 11:30 am - 11:50 am | William Sessa (Yale University, New Haven CT, USA)
"New insights into the molecular control of arteriogenesis and angiogenesis" |
| 11:50 am - 12:00 pm | Discussion
|
| 12:00 pm - 12:20 pm | Asrar Malik (University of Illinois, Chicago, IL USA)
"Functional implications of caveolae and junctions in endothelial permeability" |
| 12:20 pm - 12:30 pm | Discussion
|
| 12:30 pm | Lunch |
| 1:30 pm - 4:00 pm | Free Time |
| 4:00 pm - 6:00 pm | Poster Session |
| 6:00 pm | Dinner |
| 7:30 pm - 9:30 pm | ENGINEERING THE VASCULATURE |
| 7:30 pm - 7:50 pm | Discussion Leader: Gregg Semenza (Johns Hopkins, Baltimore MD, USA) |
| 7:50 pm - 8:15 pm | Rakesh Jain (Harvard Medical School, Boston, MA USA)
"Normalization of tumor vasculature by antiangiogenic therapy: Implications for engineering functional vasculature" |
| 8:15 pm - 8:25 pm | Discussion |
| 8:25 pm - 8:50 pm | Shulamit Levenberg (Technion, ISRAEL)
"Engineering vascularized tissues" |
| 8:50 pm - 9:00 pm | Discussion |
| 9:00 pm - 9:30 pm | Two Presentations from Selected Submitted Abstracts:
Marina Santos “Nano- and Micro-fiber combined scaffolds: An architecture tailored toward improving endothelial cell migration in bone tissue engineering constructs”
Joe Y. Tien “Engineering functional microvessels in vitro”
|
| FRIDAY |
| 7:30 am - 8:30 am | Breakfast |
| 9:00 am | Departure |
